ITCH

protein-coding gene in the species Homo sapiens
Gene gene Q18047255
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ITCH

Summary

ITCH is a gene[1]. ITCH ranks in the top 2% of gene entities by monthly Wikipedia readership (19 views/month).[2]

Key Facts

  • ITCH's instance of is recorded as gene[3].
  • ITCH's instance of is recorded as protein[4].
  • ITCH is a type of protein-coding gene[5].
  • ITCH is part of HECT, E3 ligase catalytic domain[6].
  • ITCH is part of WW domain superfamily[7].
  • ITCH is part of C2 domain superfamily[8].
  • ITCH is part of E3 ubiquitin-protein ligase, SMURF1 type[9].
  • ITCH is part of membrane protein[10].
  • ITCH is part of HECT domain, protein family[11].
  • ITCH is part of C2 domain, protein family[12].
  • ITCH is part of WW domain, protein family[13].
  • ITCH's Commons category is recorded as E3 ubiquitin-protein ligase Itchy[14].
  • ITCH comprises HECT domain[15].
  • ITCH comprises C2 domain[16].
  • ITCH comprises WW domain[17].
  • ITCH's HomoloGene ID is recorded as 88442[18].
  • ITCH's genomic start is recorded as 32951041[19].
  • ITCH's genomic start is recorded as 34363241[20].
  • ITCH's genomic end is recorded as 33099198[21].
  • ITCH's genomic end is recorded as 34540748[22].
  • ITCH's molecular function is recorded as protein binding[23].
  • ITCH's molecular function is recorded as ubiquitin-protein transferase activity[24].
  • ITCH's molecular function is recorded as transferase activity[25].
  • ITCH's molecular function is recorded as ligase activity[26].
  • ITCH's molecular function is recorded as ribonucleoprotein complex binding[27].

Why It Matters

ITCH ranks in the top 2% of gene entities by monthly Wikipedia readership (19 views/month).[2] ITCH is known by 11 alternative names across languages and contexts.[28]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . ensembl Release 105. wikidata.org.
  2. [4] . Q905695. Retrieved . wikidata.org.
  3. [5] . NCBI homo sapiens annotation release 107. Retrieved . wikidata.org.
  4. [6] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [7] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [8] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [9] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [10] . wikidata.org.
  9. [11] . wikidata.org.
  10. [12] . wikidata.org.
  11. [13] . wikidata.org.
  12. [14] . wikidata.org.
  13. [15] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  14. [16] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [17] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  16. [18] . Q20641742. Retrieved . wikidata.org.
  17. [19] . ensembl Release 105. wikidata.org.
  18. [20] . ensembl Release 105. wikidata.org.
  19. [21] . ensembl Release 105. wikidata.org.
  20. [22] . ensembl Release 105. wikidata.org.
  21. [23] . Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] . The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikimedia Foundation. dumps.wikimedia.org.
  2. [28] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). ITCH. Retrieved May 3, 2026, from https://4ort.xyz/entity/itch-q18047255
MLA “ITCH.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/itch-q18047255.
BibTeX @misc{4ortxyz_itch-q18047255_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{ITCH}}, year = {2026}, url = {https://4ort.xyz/entity/itch-q18047255}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): ITCH — https://4ort.xyz/entity/itch-q18047255 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/itch-q18047255 · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 13d ago · Mathieu Kappler · 2026-05-20 view diff on Wikidata ↗
    Part of
    Found in taxon Homo sapiens, house mouse
    Chromosome human chromosome 20
    Has parts
    + 16 other properties edited (see Wikidata diff for full list)
    "/* wbeditentity-update-languages-short:0||gsw */ QuickStatements 3.0 [[:toollabs:qs-dev/batch/32569|batch #32569]]: human gene name and description in Alemannic"
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