ISL1 transcription factor, LIM/homeodomain

mammalian protein found in Mus musculus

Protein protein Q21986053

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Summary

ISL1 transcription factor, LIM/homeodomain is a protein^[1].

Key Facts

ISL1 transcription factor, LIM/homeodomain's instance of is recorded as protein^[2].
ISL1 transcription factor, LIM/homeodomain's subclass of is recorded as protein^[3].
ISL1 transcription factor, LIM/homeodomain's UniProt protein ID is recorded as P61372^[4].
ISL1 transcription factor, LIM/homeodomain's part of is recorded as Homeobox-like domain superfamily^[5].
ISL1 transcription factor, LIM/homeodomain's part of is recorded as Homeobox domain, protein family^[6].
ISL1 transcription factor, LIM/homeodomain's part of is recorded as Zinc finger, LIM-type, protein family^[7].
ISL1 transcription factor, LIM/homeodomain's part of is recorded as Homeobox, conserved site, protein family^[8].
ISL1 transcription factor, LIM/homeodomain's has part is recorded as Homeobox domain^[9].
ISL1 transcription factor, LIM/homeodomain's has part is recorded as Zinc finger, LIM-type^[10].
ISL1 transcription factor, LIM/homeodomain's has part is recorded as Homeobox, conserved site^[11].
ISL1 transcription factor, LIM/homeodomain's RefSeq protein ID is recorded as NP_067434^[12].
ISL1 transcription factor, LIM/homeodomain's PDB structure ID is recorded as 2RGT^[13].
ISL1 transcription factor, LIM/homeodomain's PDB structure ID is recorded as 4JCJ^[14].
ISL1 transcription factor, LIM/homeodomain's molecular function is recorded as DNA binding^[15].
ISL1 transcription factor, LIM/homeodomain's molecular function is recorded as transcription coactivator activity^[16].
ISL1 transcription factor, LIM/homeodomain's molecular function is recorded as chromatin binding^[17].
ISL1 transcription factor, LIM/homeodomain's molecular function is recorded as metal ion binding^[18].
ISL1 transcription factor, LIM/homeodomain's molecular function is recorded as bHLH transcription factor binding^[19].
ISL1 transcription factor, LIM/homeodomain's molecular function is recorded as protein binding^[20].
ISL1 transcription factor, LIM/homeodomain's molecular function is recorded as cis-regulatory region sequence-specific DNA binding^[21].
ISL1 transcription factor, LIM/homeodomain's molecular function is recorded as promoter-specific chromatin binding^[22].
ISL1 transcription factor, LIM/homeodomain's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[23].
ISL1 transcription factor, LIM/homeodomain's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[24].
ISL1 transcription factor, LIM/homeodomain's molecular function is recorded as nuclear receptor binding^[25].
ISL1 transcription factor, LIM/homeodomain's molecular function is recorded as estrogen receptor binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Homeobox-like domain superfamily, Homeobox domain, protein family, Zinc finger, LIM-type, protein family, Homeobox, conserved site, protein family

Properties

Biological process negative regulation of neuron apoptotic process, peripheral nervous system neuron development, positive regulation of interleukin-1 alpha production, pituitary gland development, negative regulation of neuron differentiation, positive regulation of interleukin-12 production, axon regeneration, spinal cord motor neuron cell fate specification, trigeminal nerve development, neuron fate specification, heart morphogenesis, outflow tract morphogenesis, positive regulation of interferon-gamma production, positive regulation of granulocyte colony-stimulating factor production, negative regulation of transcription by RNA polymerase II, positive regulation of angiogenesis, positive regulation of histone acetylation, outflow tract septum morphogenesis, endocardial cushion morphogenesis, multicellular organism development, ventricular cardiac muscle tissue morphogenesis, atrial septum morphogenesis, cardiac cell fate determination, development of the heart, regulation of secondary heart field cardioblast proliferation, cardiac muscle cell myoblast differentiation, cellular response to glucocorticoid stimulus, visceral motor neuron differentiation, mesenchymal cell differentiation, positive regulation of granulocyte macrophage colony-stimulating factor production, neural crest cell migration, neuron differentiation, positive regulation of cell population proliferation, positive regulation of interleukin-1 beta production, positive regulation of interleukin-6 production, positive regulation of tumor necrosis factor production, regulation of gene expression, pancreas development, positive regulation of macrophage colony-stimulating factor production, positive regulation of vascular endothelial growth factor production, neuron fate commitment, positive regulation of DNA binding, peripheral nervous system neuron axonogenesis, spinal cord motor neuron differentiation, secondary heart field specification, innervation, negative regulation of transcription, DNA-templated, negative regulation of inflammatory response, cardiac right ventricle morphogenesis, negative regulation of canonical Wnt signaling pathway, sensory system development, pharyngeal system development, retinal ganglion cell axon guidance, transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, positive regulation of cell differentiation, transcription, DNA-templated, cell differentiation, positive regulation of tyrosine phosphorylation of STAT protein, regulation of transcription, DNA-templated, positive regulation of epithelial to mesenchymal transition, positive regulation of insulin secretion, negative regulation of intracellular estrogen receptor signaling pathway, negative regulation of epithelial cell proliferation, negative regulation of protein homodimerization activity, axonogenesis, positive regulation of transcription by RNA polymerase II, neuron fate specification

Cell component nucleoplasm, nucleus, nucleus

Encoded by Isl1

Found in taxon house mouse

Has part(s) Homeobox domain, Zinc finger, LIM-type, Homeobox, conserved site

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, transcription coactivator activity, chromatin binding, metal ion binding, bHLH transcription factor binding, protein binding, cis-regulatory region sequence-specific DNA binding, promoter-specific chromatin binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, nuclear receptor binding, estrogen receptor binding, sequence-specific DNA binding, transcription coactivator activity, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription coactivator activity, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription coactivator activity, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (4)

Ensembl protein id ENSMUSP00000044879, ENSMUSP00000135567

Pdb structure id 2RGT, 4JCJ

Refseq protein id NP_067434

Uniprot protein id P61372

🏷️ Also known as

en insulin gene enhancer protein ISL-1 en insulin related protein en Isl1 en ISL1 transcription factor, LIM/homeodomain en islet-1 en Islet 1 en Lim-homeodomain protein Islet1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ ISL1 transcription factor, LIM/homeodomain — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ ISL1 transcription factor, LIM/homeodomain — subclass of (P279): protein. UniProt. Retrieved 2017-01-19. wikidata.org.
[4] ↑ ISL1 transcription factor, LIM/homeodomain — UniProt protein ID (P352): P61372. UniProt. Retrieved 2022-05-25. wikidata.org.
[5] ↑ ISL1 transcription factor, LIM/homeodomain — part of (P361): Homeobox-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ ISL1 transcription factor, LIM/homeodomain — part of (P361): Homeobox domain, protein family. wikidata.org.
[7] ↑ ISL1 transcription factor, LIM/homeodomain — part of (P361): Zinc finger, LIM-type, protein family. wikidata.org.
[8] ↑ ISL1 transcription factor, LIM/homeodomain — part of (P361): Homeobox, conserved site, protein family. wikidata.org.
[9] ↑ ISL1 transcription factor, LIM/homeodomain — has part(s) (P527): Homeobox domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ ISL1 transcription factor, LIM/homeodomain — has part(s) (P527): Zinc finger, LIM-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ ISL1 transcription factor, LIM/homeodomain — has part(s) (P527): Homeobox, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ ISL1 transcription factor, LIM/homeodomain — RefSeq protein ID (P637): NP_067434. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ ISL1 transcription factor, LIM/homeodomain — PDB structure ID (P638): 2RGT. UniProt. Retrieved 2016-08-09. wikidata.org.
[14] ↑ ISL1 transcription factor, LIM/homeodomain — PDB structure ID (P638): 4JCJ. UniProt. Retrieved 2016-08-09. wikidata.org.
[15] ↑ ISL1 transcription factor, LIM/homeodomain — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ ISL1 transcription factor, LIM/homeodomain — molecular function (P680): transcription coactivator activity. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ ISL1 transcription factor, LIM/homeodomain — molecular function (P680): chromatin binding. Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ ISL1 transcription factor, LIM/homeodomain — molecular function (P680): metal ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ ISL1 transcription factor, LIM/homeodomain — molecular function (P680): bHLH transcription factor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ ISL1 transcription factor, LIM/homeodomain — molecular function (P680): protein binding. Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ ISL1 transcription factor, LIM/homeodomain — molecular function (P680): cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ ISL1 transcription factor, LIM/homeodomain — molecular function (P680): promoter-specific chromatin binding. Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ ISL1 transcription factor, LIM/homeodomain — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ ISL1 transcription factor, LIM/homeodomain — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ ISL1 transcription factor, LIM/homeodomain — molecular function (P680): nuclear receptor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ ISL1 transcription factor, LIM/homeodomain — molecular function (P680): estrogen receptor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ ISL1 transcription factor, LIM/homeodomain is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_isl1-transcription-factor-lim-homeodomain_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{ISL1 transcription factor, LIM/homeodomain}}, year = {2026}, url = {https://4ort.xyz/entity/isl1-transcription-factor-lim-homeodomain}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): ISL1 transcription factor, LIM/homeodomain — https://4ort.xyz/entity/isl1-transcription-factor-lim-homeodomain (retrieved 2026-05-03)

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