interleukin 6 receptor
mammalian protein found in Homo sapiens
Facts
8 properties- Instance of
- protein
- Part of
- Fibronectin type III superfamily, Immunoglobulin-like domain superfamily, Immunoglobulin-like fold, Fibronectin type III, protein family, immunoglobulin subtype, protein family, Type I cytokine receptor, cytokine-binding domain, protein family, Immunoglobulin subtype 2, protein family, immunoglobulin-like domain, protein family, Immunoglobulin domain, protein family, Long hematopoietin receptor, soluble alpha chain, conserved site, protein family[2][3][4][5][6][7][8][9][10][11]
- Biological process
- positive regulation of activation of Janus kinase activity, response to cytokine, hepatic immune response, extrinsic apoptotic signaling pathway, monocyte chemotaxis, ciliary neurotrophic factor-mediated signaling pathway, positive regulation of leukocyte chemotaxis, negative regulation of interleukin-8 production, positive regulation of osteoblast differentiation, defense response to Gram-negative bacterium, acute-phase response, positive regulation of NF-kappaB transcription factor activity, positive regulation of cell population proliferation, positive regulation of interleukin-6 production, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of chemokine production, neutrophil mediated immunity, negative regulation of collagen biosynthetic process, endocrine pancreas development, positive regulation of MAPK cascade, positive regulation of smooth muscle cell proliferation, defense response to Gram-positive bacterium, positive regulation of tyrosine phosphorylation of STAT protein, cytokine-mediated signaling pathway, interleukin-6-mediated signaling pathway, positive regulation of T-helper 1 type immune response, regulation of signaling receptor activity, positive regulation of activation of Janus kinase activity, positive regulation of interferon-gamma production, positive regulation of natural killer cell activation, positive regulation of activated T cell proliferation, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of lymphocyte proliferation, positive regulation of NK T cell activation, interleukin-6-mediated signaling pathway, positive regulation of glomerular mesangial cell proliferation
- Cell component
- integral component of membrane, membrane, plasma membrane, extracellular region, basolateral plasma membrane, apical plasma membrane, interleukin-6 receptor complex, ciliary neurotrophic factor receptor complex, extracellular space, cell surface, interleukin-6 receptor complex, external side of plasma membrane, receptor complex, interleukin-12 complex, interleukin-23 complex
- Encoded by
- IL6R
- Found in taxon
- Homo sapiens
- Has part(s)
- immunoglobulin domain, immunoglobulin subtype 2, fibronectin type III, immunoglobulin-like domain, Type I cytokine receptor, cytokine-binding domain, Long hematopoietin receptor, soluble alpha chain, conserved site, immunoglobulin subtype[12][13][14][15][16][17][18]
- Molecular function
- ciliary neurotrophic factor receptor activity, protein homodimerization activity, interleukin-6 receptor binding, protein binding, cytokine receptor activity, enzyme binding, ciliary neurotrophic factor binding, interleukin-6 receptor activity, interleukin-6 binding, cytokine receptor activity, interleukin-12 receptor binding, growth factor activity, cytokine binding, interleukin-6 binding, interleukin-12 alpha subunit binding, interleukin-23 receptor binding
🏷️ Also known as
en CD126 antigen
en gp80
en IL6R
en IL-6R 1
en IL-6 receptor subunit alpha
en interleukin 6 receptor
en interleukin-6 receptor subunit alpha
en membrane glycoprotein 80
en Receptors, Interleukin-6
🔖 Identifiers · 8
- Ensembl protein ID
- ENSP00000340589, ENSP00000357470, ENSP00000423036, ENSP00000423184, ENSP00000423668, ENSP00000477739
- Exact match
- identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov
- MeSH descriptor ID
- D019947
- MeSH tree code
- D12.776.543.750.705.852.420.400
- RefSeq protein ID
- NP_000556, NP_001193795, NP_852004, XP_005245196, XP_005245197, XP_016856688, XP_016856690, NP_001369698, NP_001369699, NP_001369700, NP_001369701, NP_001369702, NP_001369703
- UMLS CUI
- C0063717
- UniProt protein ID
- P08887
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Summary
interleukin 6 receptor is a protein[1].