interleukin 21

mammalian protein found in Homo sapiens
Protein protein Q909381
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interleukin 21

Summary

interleukin 21 is a protein[1]. It draws 23 Wikipedia views per month (protein category, ranking #141 of 987).[2]

Key Facts

  • interleukin 21's instance of is recorded as protein[3].
  • interleukin 21's UniProt protein ID is recorded as Q9HBE4[4].
  • interleukin 21's part of is recorded as four-helical cytokine-like, core[5].
  • interleukin 21's MeSH descriptor ID is recorded as D000098546[6].
  • interleukin 21's RefSeq protein ID is recorded as NP_001193935[7].
  • interleukin 21's RefSeq protein ID is recorded as NP_068575[8].
  • interleukin 21's PDB structure ID is recorded as 2OQP[9].
  • interleukin 21's PDB structure ID is recorded as 3TGX[10].
  • interleukin 21's Freebase ID is recorded as /m/026dqjz[11].
  • interleukin 21's MeSH tree code is recorded as D12.644.276.374.465.027[12].
  • interleukin 21's MeSH tree code is recorded as D12.776.467.374.465.027[13].
  • interleukin 21's MeSH tree code is recorded as D23.529.374.465.162[14].
  • interleukin 21's molecular function is recorded as cytokine activity[15].
  • interleukin 21's molecular function is recorded as interleukin-2 receptor binding[16].
  • interleukin 21's molecular function is recorded as cytokine receptor binding[17].
  • interleukin 21's cell component is recorded as intracellular anatomical structure[18].
  • interleukin 21's cell component is recorded as extracellular space[19].
  • interleukin 21's cell component is recorded as extracellular region[20].
  • interleukin 21's biological process is recorded as positive regulation of inflammatory response[21].
  • interleukin 21's biological process is recorded as positive regulation of cytokine production[22].
  • interleukin 21's biological process is recorded as cell maturation[23].
  • interleukin 21's biological process is recorded as positive regulation of B cell proliferation[24].
  • interleukin 21's biological process is recorded as positive regulation of tissue remodeling[25].
  • interleukin 21's biological process is recorded as positive regulation of T cell proliferation[26].
  • interleukin 21's biological process is recorded as immune response[27].

Why It Matters

interleukin 21 draws 23 Wikipedia views per month (protein category, ranking #141 of 987).[2] It has Wikipedia articles in 9 language editions, a strong signal of global cultural recognition.[28] It is known by 4 alternative names across languages and contexts.[29]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . Q905695. Retrieved . wikidata.org.
  2. [4] . Q905695. Retrieved . wikidata.org.
  3. [5] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] . wikidata.org.
  5. [7] . Q20641742. Retrieved . wikidata.org.
  6. [8] . Q20641742. Retrieved . wikidata.org.
  7. [9] . Q905695. Retrieved . wikidata.org.
  8. [10] . Q905695. Retrieved . wikidata.org.
  9. [11] . Freebase Data Dumps. wikidata.org.
  10. [12] . wikidata.org.
  11. [13] . wikidata.org.
  12. [14] . wikidata.org.
  13. [15] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] . Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] . Biology of IL-21 and the IL-21 receptor. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] . Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] . Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] . Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] . IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] . Cloning and characterization of an isoform of interleukin-21. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] . Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] . Cloning and expression of human interleukin-21 cDNA in E.coli. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikimedia Foundation. dumps.wikimedia.org.
  2. [28] . Wikidata sitelinks. wikidata.org.
  3. [29] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). interleukin 21. Retrieved May 3, 2026, from https://4ort.xyz/entity/interleukin-21
MLA “interleukin 21.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/interleukin-21.
BibTeX @misc{4ortxyz_interleukin-21_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{interleukin 21}}, year = {2026}, url = {https://4ort.xyz/entity/interleukin-21}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): interleukin 21 — https://4ort.xyz/entity/interleukin-21 (retrieved 2026-05-03)

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