Interleukin 12B
mammalian protein found in Homo sapiens
Facts
9 properties- Instance of
- protein
- Part of
- Fibronectin type III superfamily, Immunoglobulin-like fold, Immunoglobulin-like domain superfamily, interleukin-12 beta, Fibronectin type III, protein family, Interleukin-12 beta, central domain, protein family, Immunoglobulin subtype 2, protein family, immunoglobulin-like domain, protein family, Long hematopoietin receptor, soluble alpha chain, conserved site, protein family[3][4][5][6][7][8][9][10][11]
- Biological process
- positive regulation of cell adhesion, negative regulation of interleukin-10 production, negative regulation of smooth muscle cell proliferation, positive regulation of inflammatory response, sexual reproduction, positive regulation of interleukin-12 production, positive regulation of smooth muscle cell apoptotic process, defense response to Gram-negative bacterium, positive regulation of interleukin-10 production, positive regulation of T cell mediated cytotoxicity, natural killer cell activation, positive regulation of natural killer cell activation, positive regulation of interferon-gamma production, positive regulation of osteoclast differentiation, positive regulation of T-helper 17 cell lineage commitment, response to organic substance, positive regulation of NK T cell activation, positive regulation of natural killer cell proliferation, natural killer cell activation involved in immune response, cell surface receptor signaling pathway, positive regulation of NK T cell proliferation, positive regulation of T-helper 17 type immune response, negative regulation of inflammatory response to antigenic stimulus, defense response to virus, positive regulation of tissue remodeling, positive regulation of T-helper 1 type immune response, positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of T cell proliferation, positive regulation of memory T cell differentiation, cellular response to interferon-gamma, positive regulation of tumor necrosis factor production, T-helper 1 type immune response, sensory perception of pain, response to UV-B, positive regulation of interleukin-17 production, cellular response to lipopolysaccharide, negative regulation of interleukin-17 production, T-helper cell differentiation, cell migration, positive regulation of lymphocyte proliferation, positive regulation of mononuclear cell proliferation, positive regulation of activated T cell proliferation, defense response to protozoan, positive regulation of defense response to virus by host, positive regulation of activation of Janus kinase activity, regulation of tyrosine phosphorylation of STAT protein, positive regulation of tyrosine phosphorylation of STAT protein, interleukin-12-mediated signaling pathway, cell population proliferation, regulation of signaling receptor activity, T-helper 1 cell cytokine production, cytokine-mediated signaling pathway, interleukin-23-mediated signaling pathway, positive regulation of NIK/NF-kappaB signaling, positive regulation of T-helper 1 type immune response, positive regulation of activation of Janus kinase activity, positive regulation of interferon-gamma production, positive regulation of natural killer cell activation, positive regulation of activated T cell proliferation, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of lymphocyte proliferation, positive regulation of NK T cell activation
- Cell component
- cytoplasm, membrane, interleukin-12 complex, interleukin-23 complex, extracellular region, extracellular space, endoplasmic reticulum lumen, cytosol, late endosome lumen, cell surface, external side of plasma membrane, receptor complex, interleukin-12 complex, interleukin-23 complex
- Encoded by
- IL12B
- Found in taxon
- Homo sapiens
- Has part(s)
- immunoglobulin subtype 2, fibronectin type III, immunoglobulin-like domain, Long hematopoietin receptor, soluble alpha chain, conserved site, Interleukin-12 beta, central domain[12][13][14][15][16]
- Molecular function
- cytokine activity, interleukin-23 receptor binding, protein homodimerization activity, interleukin-12 receptor binding, protein binding, identical protein binding, protein heterodimerization activity, interleukin-12 alpha subunit binding, cytokine receptor activity, growth factor activity, cytokine receptor binding, cytokine receptor activity, interleukin-12 receptor binding, growth factor activity, cytokine binding, interleukin-12 alpha subunit binding, interleukin-23 receptor binding
- Physically interacts with
- tildrakizumab[2]
🏷️ Also known as
en CLMF p40
en cytotoxic lymphocyte maturation factor 40 kDa subunit
en IL12B
en IL-12 subunit p40
en IL12, subunit p40
en Interleukin 12B
en interleukin-12 beta chain
en interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
en interleukin 12, p40
en interleukin-12 subunit beta
en natural killer cell stimulatory factor, 40 kD subunit
en NK cell stimulatory factor chain 2
en NKSF2
🔖 Identifiers · 7
- Ensembl protein ID
- ENSP00000231228
- MeSH descriptor ID
- D053762
- MeSH tree code
- D12.644.276.374.465.512.500, D12.644.276.374.465.759.249, D12.776.467.374.465.512.500, D12.776.467.374.465.759.249, D23.529.374.465.512.500, D23.529.374.465.550.249
- RefSeq protein ID
- NP_002178
- UMLS CUI
- C1121402
- UniProt protein ID
- P29460
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Summary
Interleukin 12B is a protein[1].