Interleukin-1 receptor-associated kinase 3

mammalian protein found in Rattus norvegicus

Protein protein Q29526048

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Summary

Interleukin-1 receptor-associated kinase 3 is a protein^[1].

Key Facts

Interleukin-1 receptor-associated kinase 3's instance of is recorded as protein^[2].
Interleukin-1 receptor-associated kinase 3's UniProt protein ID is recorded as B2RYC8^[3].
Interleukin-1 receptor-associated kinase 3's part of is recorded as Interleukin-1 receptor-associated kinase 3^[4].
Interleukin-1 receptor-associated kinase 3's part of is recorded as Protein kinase-like domain superfamily^[5].
Interleukin-1 receptor-associated kinase 3's part of is recorded as Death-like domain superfamily^[6].
Interleukin-1 receptor-associated kinase 3's part of is recorded as Death domain, protein family^[7].
Interleukin-1 receptor-associated kinase 3's part of is recorded as Protein kinase domain, protein family^[8].
Interleukin-1 receptor-associated kinase 3's has part is recorded as protein kinase domain^[9].
Interleukin-1 receptor-associated kinase 3's has part is recorded as death domain^[10].
Interleukin-1 receptor-associated kinase 3's RefSeq protein ID is recorded as NP_001101571^[11].
Interleukin-1 receptor-associated kinase 3's RefSeq protein ID is recorded as XP_017450343^[12].
Interleukin-1 receptor-associated kinase 3's RefSeq protein ID is recorded as XP_038935059^[13].
Interleukin-1 receptor-associated kinase 3's RefSeq protein ID is recorded as XP_038935060^[14].
Interleukin-1 receptor-associated kinase 3's RefSeq protein ID is recorded as XP_038935061^[15].
Interleukin-1 receptor-associated kinase 3's RefSeq protein ID is recorded as XP_038935062^[16].
Interleukin-1 receptor-associated kinase 3's RefSeq protein ID is recorded as XP_038935063^[17].
Interleukin-1 receptor-associated kinase 3's RefSeq protein ID is recorded as XP_038935064^[18].
Interleukin-1 receptor-associated kinase 3's molecular function is recorded as magnesium ion binding^[19].
Interleukin-1 receptor-associated kinase 3's molecular function is recorded as protein kinase activity^[20].
Interleukin-1 receptor-associated kinase 3's molecular function is recorded as protein serine/threonine kinase activity^[21].
Interleukin-1 receptor-associated kinase 3's molecular function is recorded as ATP binding^[22].
Interleukin-1 receptor-associated kinase 3's molecular function is recorded as kinase activity^[23].
Interleukin-1 receptor-associated kinase 3's molecular function is recorded as protein homodimerization activity^[24].
Interleukin-1 receptor-associated kinase 3's molecular function is recorded as protein heterodimerization activity^[25].
Interleukin-1 receptor-associated kinase 3's molecular function is recorded as molecular function^[26].

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Quick Facts

Instance of protein

Part of Interleukin-1 receptor-associated kinase 3, Protein kinase-like domain superfamily, Death-like domain superfamily, Death domain, protein family, Protein kinase domain, protein family

Properties

Biological process toll-like receptor signaling pathway, MyD88-dependent toll-like receptor signaling pathway, protein phosphorylation, signal transduction, positive regulation of macrophage tolerance induction, negative regulation of macrophage cytokine production, phosphorylation, cytokine-mediated signaling pathway, negative regulation of NF-kappaB transcription factor activity, response to peptidoglycan, response to lipopolysaccharide, negative regulation of interleukin-12 production, negative regulation of interleukin-6 production, negative regulation of tumor necrosis factor production, negative regulation of toll-like receptor signaling pathway, intracellular signal transduction, negative regulation of protein catabolic process, negative regulation of protein-containing complex disassembly, regulation of protein-containing complex disassembly, response to exogenous dsRNA, negative regulation of MAP kinase activity, negative regulation of innate immune response, protein autophosphorylation, positive regulation of NF-kappaB transcription factor activity, interleukin-1-mediated signaling pathway, response to interleukin-1, biological process, cytokine-mediated signaling pathway, negative regulation of interleukin-12 production, negative regulation of tumor necrosis factor production

Cell component nucleus, cytoplasm, cellular component, plasma membrane

Encoded by Irak3

Found in taxon brown rat

Has part(s) protein kinase domain, death domain

Imported from wholeness_audit_2026-05-02

Molecular function magnesium ion binding, protein kinase activity, protein serine/threonine kinase activity, ATP binding, kinase activity, protein homodimerization activity, protein heterodimerization activity, molecular function

External References (3)

Ensembl protein id ENSRNOP00000005686

Refseq protein id NP_001101571, XP_017450343, XP_038935059, XP_038935060, XP_038935061, XP_038935062, XP_038935063, XP_038935064

Uniprot protein id B2RYC8

🏷️ Also known as

en Interleukin-1 receptor-associated kinase 3 en Irak3

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Interleukin-1 receptor-associated kinase 3 — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Interleukin-1 receptor-associated kinase 3 — UniProt protein ID (P352): B2RYC8. UniProt. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Interleukin-1 receptor-associated kinase 3 — part of (P361): Interleukin-1 receptor-associated kinase 3. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Interleukin-1 receptor-associated kinase 3 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Interleukin-1 receptor-associated kinase 3 — part of (P361): Death-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Interleukin-1 receptor-associated kinase 3 — part of (P361): Death domain, protein family. wikidata.org.
[8] ↑ Interleukin-1 receptor-associated kinase 3 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[9] ↑ Interleukin-1 receptor-associated kinase 3 — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Interleukin-1 receptor-associated kinase 3 — has part(s) (P527): death domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Interleukin-1 receptor-associated kinase 3 — RefSeq protein ID (P637): NP_001101571. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ Interleukin-1 receptor-associated kinase 3 — RefSeq protein ID (P637): XP_017450343. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ Interleukin-1 receptor-associated kinase 3 — RefSeq protein ID (P637): XP_038935059. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ Interleukin-1 receptor-associated kinase 3 — RefSeq protein ID (P637): XP_038935060. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Interleukin-1 receptor-associated kinase 3 — RefSeq protein ID (P637): XP_038935061. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Interleukin-1 receptor-associated kinase 3 — RefSeq protein ID (P637): XP_038935062. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Interleukin-1 receptor-associated kinase 3 — RefSeq protein ID (P637): XP_038935063. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Interleukin-1 receptor-associated kinase 3 — RefSeq protein ID (P637): XP_038935064. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Interleukin-1 receptor-associated kinase 3 — molecular function (P680): magnesium ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Interleukin-1 receptor-associated kinase 3 — molecular function (P680): protein kinase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Interleukin-1 receptor-associated kinase 3 — molecular function (P680): protein serine/threonine kinase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Interleukin-1 receptor-associated kinase 3 — molecular function (P680): ATP binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Interleukin-1 receptor-associated kinase 3 — molecular function (P680): kinase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Interleukin-1 receptor-associated kinase 3 — molecular function (P680): protein homodimerization activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Interleukin-1 receptor-associated kinase 3 — molecular function (P680): protein heterodimerization activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Interleukin-1 receptor-associated kinase 3 — molecular function (P680): molecular function. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Interleukin-1 receptor-associated kinase 3 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Interleukin-1 receptor-associated kinase 3. Retrieved May 3, 2026, from https://4ort.xyz/entity/interleukin-1-receptor-associated-kinase-3

MLA

“Interleukin-1 receptor-associated kinase 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/interleukin-1-receptor-associated-kinase-3.

BibTeX

@misc{4ortxyz_interleukin-1-receptor-associated-kinase-3_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Interleukin-1 receptor-associated kinase 3}}, year = {2026}, url = {https://4ort.xyz/entity/interleukin-1-receptor-associated-kinase-3}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Interleukin-1 receptor-associated kinase 3 — https://4ort.xyz/entity/interleukin-1-receptor-associated-kinase-3 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/interleukin-1-receptor-associated-kinase-3 · Last refreshed: May 3, 2026