Interleukin 1 receptor associated kinase 1

mammalian protein found in Homo sapiens

Protein protein Q21173372

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Summary

Interleukin 1 receptor associated kinase 1 is a protein^[1]. It is known by 7 alternative names across languages and contexts.^[2]

Key Facts

Interleukin 1 receptor associated kinase 1's instance of is recorded as protein^[3].
Interleukin 1 receptor associated kinase 1 is part of Interleukin-1 receptor-associated kinase 1^[4].
Interleukin 1 receptor associated kinase 1 is part of Protein kinase-like domain superfamily^[5].
Interleukin 1 receptor associated kinase 1 is part of Death-like domain superfamily^[6].
Interleukin 1 receptor associated kinase 1 is part of membrane protein^[7].
Interleukin 1 receptor associated kinase 1 is part of Interleukin-1 receptor-associated kinase 1, death domain, protein family^[8].
Interleukin 1 receptor associated kinase 1 is part of Death domain, protein family^[9].
Interleukin 1 receptor associated kinase 1 is part of Protein kinase domain, protein family^[10].
Interleukin 1 receptor associated kinase 1 is part of Protein kinase, ATP binding site, protein family^[11].
Interleukin 1 receptor associated kinase 1 is part of Serine/threonine-protein kinase, active site, protein family^[12].
Interleukin 1 receptor associated kinase 1 comprises death domain^[13].
Interleukin 1 receptor associated kinase 1 comprises protein kinase, ATP binding site^[14].
Interleukin 1 receptor associated kinase 1 comprises protein kinase domain^[15].
Interleukin 1 receptor associated kinase 1 comprises serine/threonine-protein kinase, active site^[16].
Interleukin 1 receptor associated kinase 1 comprises Interleukin-1 receptor-associated kinase 1, death domain^[17].
Interleukin 1 receptor associated kinase 1's molecular function is recorded as transferase activity^[18].
Interleukin 1 receptor associated kinase 1's molecular function is recorded as protein kinase activity^[19].
Interleukin 1 receptor associated kinase 1's molecular function is recorded as nucleotide binding^[20].
Interleukin 1 receptor associated kinase 1's molecular function is recorded as heat shock protein binding^[21].
Interleukin 1 receptor associated kinase 1's molecular function is recorded as protein homodimerization activity^[22].
Interleukin 1 receptor associated kinase 1's molecular function is recorded as kinase activity^[23].
Interleukin 1 receptor associated kinase 1's molecular function is recorded as NF-kappaB-inducing kinase activity^[24].
Interleukin 1 receptor associated kinase 1's molecular function is recorded as protein binding^[25].
Interleukin 1 receptor associated kinase 1's molecular function is recorded as protein heterodimerization activity^[26].
Interleukin 1 receptor associated kinase 1's molecular function is recorded as ATP binding^[27].

Why It Matters

Interleukin 1 receptor associated kinase 1 is known by 7 alternative names across languages and contexts.^[2]

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Quick Facts

Instance of protein

Part of Interleukin-1 receptor-associated kinase 1, Protein kinase-like domain superfamily, Death-like domain superfamily, membrane protein, Interleukin-1 receptor-associated kinase 1, death domain, protein family, Death domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process cellular response to heat, response to interleukin-1, positive regulation of MAP kinase activity, regulation of cytokine-mediated signaling pathway, phosphorylation, cytokine-mediated signaling pathway, immune system process, ageing, negative regulation of apoptotic process, activation of NF-kappaB-inducing kinase activity, MyD88-dependent toll-like receptor signaling pathway, toll-like receptor signaling pathway, positive regulation of transcription, DNA-templated, protein phosphorylation, JNK cascade, response to lipopolysaccharide, transmembrane receptor protein serine/threonine kinase signaling pathway, positive regulation of NF-kappaB transcription factor activity, protein complex oligomerization, positive regulation of I-kappaB kinase/NF-kappaB signaling, protein autophosphorylation, toll-like receptor 9 signaling pathway, cellular response to lipopolysaccharide, negative regulation of NF-kappaB transcription factor activity, nucleotide-binding oligomerization domain containing signaling pathway, positive regulation of type I interferon production, cellular response to hypoxia, lipopolysaccharide-mediated signaling pathway, signal transduction, positive regulation of smooth muscle cell proliferation, toll-like receptor 4 signaling pathway, toll-like receptor 2 signaling pathway, innate immune response, type I interferon signaling pathway, viral process, interleukin-1-mediated signaling pathway, cytokine-mediated signaling pathway, intracellular signal transduction, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of NF-kappaB transcription factor activity, interleukin-1-mediated signaling pathway, toll-like receptor 2 signaling pathway, innate immune response, cellular response to lipopolysaccharide, positive regulation of NIK/NF-kappaB signaling, positive regulation of leukocyte adhesion to vascular endothelial cell

Cell component membrane, lipid droplet, plasma membrane, endosome membrane, interleukin-1 receptor complex, nucleus, cytoplasm, cytosol, plasma membrane

Ec enzyme number 2.7.11.1

Encoded by IRAK1

Found in taxon Homo sapiens

Has part(s) death domain, protein kinase, ATP binding site, protein kinase domain, serine/threonine-protein kinase, active site, Interleukin-1 receptor-associated kinase 1, death domain

Molecular function transferase activity, protein kinase activity, nucleotide binding, heat shock protein binding, protein homodimerization activity, kinase activity, NF-kappaB-inducing kinase activity, protein binding, protein heterodimerization activity, ATP binding, protein serine/threonine kinase activity, protein serine/threonine kinase activity, protein serine/threonine kinase activity

External References (3)

Ensembl protein id ENSP00000358991, ENSP00000358997, ENSP00000377291, ENSP00000358990, ENSP00000392662, ENSP00000399974, ENSP00000403730, ENSP00000406249, ENSP00000410953, ENSP00000411809

Refseq protein id NP_001020413, NP_001020414, NP_001560, XP_005274725

Uniprot protein id P51617

🏷️ Also known as

en interleukin-1 receptor-associated kinase 1 en Interleukin 1 receptor associated kinase 1 en IRAK-1 en IRAK1 en mPLK en Pelle homolog en Pelle-like protein kinase

References

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📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Interleukin 1 receptor associated kinase 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/interleukin-1-receptor-associated-kinase-1

MLA

“Interleukin 1 receptor associated kinase 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/interleukin-1-receptor-associated-kinase-1.

BibTeX

@misc{4ortxyz_interleukin-1-receptor-associated-kinase-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Interleukin 1 receptor associated kinase 1}}, year = {2026}, url = {https://4ort.xyz/entity/interleukin-1-receptor-associated-kinase-1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Interleukin 1 receptor associated kinase 1 — https://4ort.xyz/entity/interleukin-1-receptor-associated-kinase-1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/interleukin-1-receptor-associated-kinase-1 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → IRAK1

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → transferase activity, protein kinase activity, nucleotide binding +10

+ 10 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ Ec enzyme number: 2.7.11.1, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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