Properties
Biological process
positive regulation of protein phosphorylation, smooth muscle adaptation, positive regulation of calcidiol 1-monooxygenase activity, negative regulation of insulin receptor signaling pathway, cellular response to mechanical stimulus, positive regulation of interleukin-8 production, positive regulation of mitotic nuclear division, response to carbohydrate, embryo implantation, regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of cell population proliferation, apoptotic process, cellular response to organic substance, positive regulation of phagocytosis, regulation of insulin secretion, neutrophil chemotaxis, positive regulation of transcription, DNA-templated, positive regulation of protein export from nucleus, positive regulation of prostaglandin secretion, positive regulation of myosin light chain kinase activity, negative regulation of MAP kinase activity, positive regulation of T cell proliferation, positive regulation of interleukin-6 production, inflammatory response, negative regulation of lipid metabolic process, sequestering of triglyceride, hyaluronan biosynthetic process, positive regulation of heterotypic cell-cell adhesion, positive regulation of lipid catabolic process, cellular response to organic cyclic compound, positive regulation of fever generation, positive regulation of DNA-binding transcription factor activity, positive regulation of angiogenesis, response to lipopolysaccharide, positive regulation of NF-kappaB transcription factor activity, positive regulation of granulocyte macrophage colony-stimulating factor production, immune response, ectopic germ cell programmed cell death, leukocyte migration, lipopolysaccharide-mediated signaling pathway, positive regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of cell adhesion molecule production, response to ATP, monocyte aggregation, protein kinase B signaling, positive regulation of nitric oxide biosynthetic process, cell-cell signaling, positive regulation of monocyte chemotactic protein-1 production, regulation of nitric-oxide synthase activity, positive regulation of membrane protein ectodomain proteolysis, positive regulation of interferon-gamma production, MAPK cascade, positive regulation of histone acetylation, positive regulation of gene expression, negative regulation of glucose transmembrane transport, interleukin-1 beta production, positive regulation of T cell mediated immunity, extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of vascular endothelial growth factor production, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of lipid catabolic process, negative regulation of adiponectin secretion, regulation of establishment of endothelial barrier, positive regulation of cell division, signal transduction, positive regulation of transcription by RNA polymerase II, cytokine-mediated signaling pathway, regulation of defense response to virus by host, fever generation, positive regulation of JNK cascade, fever generation, positive regulation of cell population proliferation, regulation of signaling receptor activity, positive regulation of vascular endothelial growth factor production, positive regulation of gene expression, positive regulation of epithelial to mesenchymal transition, cytokine-mediated signaling pathway, positive regulation of cell migration, neutrophil chemotaxis, interleukin-6 production, positive regulation of interleukin-6 production, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of angiogenesis, positive regulation of transcription by RNA polymerase II, positive regulation of JNK cascade, astrocyte activation, regulation of neurogenesis, negative regulation of neurogenesis, negative regulation of synaptic transmission, regulation of nitric-oxide synthase activity, positive regulation of glial cell proliferation, regulation of ERK1 and ERK2 cascade, interleukin-1-mediated signaling pathway, cellular response to lipopolysaccharide, positive regulation of neuroinflammatory response, positive regulation of p38MAPK cascade, positive regulation of NIK/NF-kappaB signaling, positive regulation of T-helper 1 cell cytokine production, response to lipopolysaccharide, positive regulation of gene expression, positive regulation of prostaglandin biosynthetic process, positive regulation of interleukin-6 production, positive regulation of complement activation, positive regulation of inflammatory response, response to interleukin-1, positive regulation of RNA biosynthetic process
Has part(s)
Interleukin-1 conserved site, Interleukin-1 propeptide
Has parts
Interleukin-1 conserved site, Interleukin-1 propeptide
Molecular function
protein domain specific binding, interleukin-1 receptor binding, cytokine activity, cytokine activity, integrin binding, protein binding
Part of
interleukin-1 beta, Cytokine IL1/FGF, interleukin-1 family, Interleukin-1 propeptide family, Interleukin-1 conserved site, protein family
External References (10)
Chembl id
CHEMBL2074848
Ensembl protein id
ENSP00000263341, ENSP00000400854, ENSP00000407219, ENSP00000409680
Freebase id
/m/0d1t6_
Guide to pharmacology ligand id
4974
Mesh descriptor id
C508585
Microsoft academic id (discontinued)
2908937167
Pdb structure id
1HIB, 1I1B, 1IOB, 1ITB, 1L2H, 1S0L, 1T4Q, 1TOO, 1TP0, 1TWE, 1TWM, 21BI, 2I1B, 2KH2, 2NVH, 31BI, 3O4O, 3POK, 41BI, 4DEP, 4G6J, 4G6M, 4GAI, 4I1B, 5I1B, 6I1B, 7I1B, 9ILB, 4GAF, 5BVP
Refseq protein id
NP_000567, XP_016859477
Transporter classification database id
1.A.109.1.2
Uniprot protein id
P01584