Interferon regulatory factor 3

mammalian protein found in Homo sapiens

Protein protein Q5973468

Press Enter · cited answer in seconds

Interferon regulatory factor 3

Summary

Interferon regulatory factor 3 is a protein^[1].

Key Facts

Interferon regulatory factor 3's instance of is recorded as protein^[2].
Interferon regulatory factor 3's UniProt protein ID is recorded as Côa^[3].
Interferon regulatory factor 3's part of is recorded as winged helix DNA-binding domain superfamily^[4].
Interferon regulatory factor 3's part of is recorded as SMAD-like domain superfamily^[5].
Interferon regulatory factor 3's part of is recorded as Winged helix-like DNA-binding domain superfamily^[6].
Interferon regulatory factor 3's part of is recorded as SMAD/FHA domain superfamily^[7].
Interferon regulatory factor 3's part of is recorded as interferon regulatory factors^[8].
Interferon regulatory factor 3's part of is recorded as Interferon regulatory factor-3, protein family^[9].
Interferon regulatory factor 3's has part is recorded as Interferon regulatory factor-3^[10].
Interferon regulatory factor 3's has part is recorded as Interferon regulatory factor DNA-binding domain^[11].
Interferon regulatory factor 3's has part is recorded as Interferon regulatory factor, conserved site^[12].
Interferon regulatory factor 3's RefSeq protein ID is recorded as NP_001184051^[13].
Interferon regulatory factor 3's RefSeq protein ID is recorded as NP_001184052^[14].
Interferon regulatory factor 3's RefSeq protein ID is recorded as NP_001184053^[15].
Interferon regulatory factor 3's RefSeq protein ID is recorded as NP_001184054^[16].
Interferon regulatory factor 3's RefSeq protein ID is recorded as NP_001184055^[17].
Interferon regulatory factor 3's RefSeq protein ID is recorded as NP_001184056^[18].
Interferon regulatory factor 3's RefSeq protein ID is recorded as NP_001184057^[19].
Interferon regulatory factor 3's RefSeq protein ID is recorded as NP_001562^[20].
Interferon regulatory factor 3's RefSeq protein ID is recorded as XP_006723260^[21].
Interferon regulatory factor 3's RefSeq protein ID is recorded as XP_006723261^[22].
Interferon regulatory factor 3's RefSeq protein ID is recorded as XP_006723263^[23].
Interferon regulatory factor 3's RefSeq protein ID is recorded as XP_006723264^[24].
Interferon regulatory factor 3's RefSeq protein ID is recorded as XP_016882255^[25].
Interferon regulatory factor 3's RefSeq protein ID is recorded as XP_016882256^[26].

⭐ Popularity Graph

0/100 long tail

Quick Facts

Instance of protein

Part of winged helix DNA-binding domain superfamily, SMAD-like domain superfamily, Winged helix-like DNA-binding domain superfamily, SMAD/FHA domain superfamily, interferon regulatory factors, Interferon regulatory factor-3, protein family

Properties

Biological process apoptotic process, positive regulation of type I interferon-mediated signaling pathway, macrophage apoptotic process, regulation of transcription, DNA-templated, response to bacterium, response to exogenous dsRNA, positive regulation of interferon-alpha production, MDA-5 signaling pathway, interferon-gamma-mediated signaling pathway, immune system process, negative regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, cellular response to dsRNA, transcription, DNA-templated, cellular response to DNA damage stimulus, TRIF-dependent toll-like receptor signaling pathway, response to lipopolysaccharide, defense response to virus, type I interferon signaling pathway, positive regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of type I interferon production, programmed necrotic cell death, viral process, cellular response to lipopolysaccharide, positive regulation of type I interferon production, lipopolysaccharide-mediated signaling pathway, positive regulation of interferon-beta production, innate immune response, regulation of type I interferon production, positive regulation of transcription by RNA polymerase II, negative regulation of defense response to virus by host, regulation of gene expression, regulation of inflammatory response, cellular response to exogenous dsRNA, positive regulation of transcription, DNA-templated, type I interferon signaling pathway, immune system process, positive regulation of interferon-alpha production, positive regulation of interferon-beta production, TRIF-dependent toll-like receptor signaling pathway, positive regulation of type I interferon production

Cell component cytoplasm, nucleoplasm, nucleus, cytosol, nucleus

Encoded by IRF3

Found in taxon Homo sapiens

Has part(s) Interferon regulatory factor-3, Interferon regulatory factor DNA-binding domain, Interferon regulatory factor, conserved site

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, protein homodimerization activity, DNA-binding transcription factor activity, transcription coregulator activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, protein binding, protein domain specific binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, identical protein binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, identical protein binding, protein homodimerization activity

External References (4)

Ensembl protein id ENSP00000472700, ENSP00000310127, ENSP00000366344, ENSP00000400378, ENSP00000469113, ENSP00000470512, ENSP00000471358, ENSP00000471896, ENSP00000366339, ENSP00000468911, ENSP00000469067, ENSP00000470069, ENSP00000470140, ENSP00000470431, ENSP00000470436, ENSP00000470905, ENSP00000471402, ENSP00000471517, ENSP00000472223, ENSP00000472582, ENSP00000472601, ENSP00000473128, ENSP00000473176, ENSP00000473232

Pdb structure id 3QU6, 1J2F, 1QWT, 1T2K, 1ZOQ, 2O61, 2O6G, 2PI0, 3A77, 5JEO, 5JEK, 5JER, 5JEM, 5JEL, 5JEJ

Refseq protein id NP_001184051, NP_001184052, NP_001184053, NP_001184054, NP_001184055, NP_001184056, NP_001184057, NP_001562, XP_006723260, XP_006723261, XP_006723263, XP_006723264, XP_016882255, XP_016882256, XP_024307260, XP_024307261, XP_024307262, XP_024307263, XP_024307264, XP_024307265, XP_024307266

Uniprot protein id Côa

🏷️ Also known as

en Interferon regulatory factor 3 en IRF3 en uniprot:Q14653

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Interferon regulatory factor 3 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Interferon regulatory factor 3 — UniProt protein ID (P352): Côa. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Interferon regulatory factor 3 — part of (P361): winged helix DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Interferon regulatory factor 3 — part of (P361): SMAD-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Interferon regulatory factor 3 — part of (P361): Winged helix-like DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Interferon regulatory factor 3 — part of (P361): SMAD/FHA domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Interferon regulatory factor 3 — part of (P361): interferon regulatory factors. wikidata.org.
[9] ↑ Interferon regulatory factor 3 — part of (P361): Interferon regulatory factor-3, protein family. wikidata.org.
[10] ↑ Interferon regulatory factor 3 — has part(s) (P527): Interferon regulatory factor-3. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Interferon regulatory factor 3 — has part(s) (P527): Interferon regulatory factor DNA-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Interferon regulatory factor 3 — has part(s) (P527): Interferon regulatory factor, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): NP_001184051. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): NP_001184052. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): NP_001184053. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): NP_001184054. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): NP_001184055. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): NP_001184056. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): NP_001184057. Q20641742. Retrieved 2020-05-30. wikidata.org.
[20] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): NP_001562. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): XP_006723260. Q20641742. Retrieved 2020-05-30. wikidata.org.
[22] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): XP_006723261. Q20641742. Retrieved 2020-05-30. wikidata.org.
[23] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): XP_006723263. Q20641742. Retrieved 2020-05-30. wikidata.org.
[24] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): XP_006723264. Q20641742. Retrieved 2020-05-30. wikidata.org.
[25] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): XP_016882255. Q20641742. Retrieved 2020-05-30. wikidata.org.
[26] ↑ Interferon regulatory factor 3 — RefSeq protein ID (P637): XP_016882256. Q20641742. Retrieved 2020-05-30. wikidata.org.

Class ancestry

[1] ↑ Interferon regulatory factor 3 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Interferon regulatory factor 3. Retrieved May 3, 2026, from https://4ort.xyz/entity/interferon-regulatory-factor-3

MLA

“Interferon regulatory factor 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/interferon-regulatory-factor-3.

BibTeX

@misc{4ortxyz_interferon-regulatory-factor-3_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Interferon regulatory factor 3}}, year = {2026}, url = {https://4ort.xyz/entity/interferon-regulatory-factor-3}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Interferon regulatory factor 3 — https://4ort.xyz/entity/interferon-regulatory-factor-3 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/interferon-regulatory-factor-3 · Last refreshed: May 3, 2026