Interferon gamma inducible protein 16

mammalian protein found in Homo sapiens

Protein protein Q21097293

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Interferon gamma inducible protein 16

Summary

Interferon gamma inducible protein 16 is a protein^[1].

Key Facts

Interferon gamma inducible protein 16's instance of is recorded as protein^[2].
Interferon gamma inducible protein 16's UniProt protein ID is recorded as Nanjing^[3].
Interferon gamma inducible protein 16's RefSeq protein ID is recorded as NP_001193496^[4].
Interferon gamma inducible protein 16's RefSeq protein ID is recorded as NP_005522^[5].
Interferon gamma inducible protein 16's RefSeq protein ID is recorded as XP_016856639^[6].
Interferon gamma inducible protein 16's RefSeq protein ID is recorded as NP_001351796^[7].
Interferon gamma inducible protein 16's RefSeq protein ID is recorded as NP_001363516^[8].
Interferon gamma inducible protein 16's RefSeq protein ID is recorded as NP_001363517^[9].
Interferon gamma inducible protein 16's RefSeq protein ID is recorded as NP_001363518^[10].
Interferon gamma inducible protein 16's RefSeq protein ID is recorded as NP_001363520^[11].
Interferon gamma inducible protein 16's RefSeq protein ID is recorded as NP_001363521^[12].
Interferon gamma inducible protein 16's PDB structure ID is recorded as 2OQ0^[13].
Interferon gamma inducible protein 16's PDB structure ID is recorded as 3B6Y^[14].
Interferon gamma inducible protein 16's PDB structure ID is recorded as 3RLN^[15].
Interferon gamma inducible protein 16's PDB structure ID is recorded as 3RLO^[16].
Interferon gamma inducible protein 16's PDB structure ID is recorded as 3RNU^[17].
Interferon gamma inducible protein 16's PDB structure ID is recorded as 4QGU^[18].
Interferon gamma inducible protein 16's molecular function is recorded as DNA-binding transcription repressor activity, RNA polymerase II-specific^[19].
Interferon gamma inducible protein 16's molecular function is recorded as identical protein binding^[20].
Interferon gamma inducible protein 16's molecular function is recorded as double-stranded DNA binding^[21].
Interferon gamma inducible protein 16's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[22].
Interferon gamma inducible protein 16's molecular function is recorded as DNA binding^[23].
Interferon gamma inducible protein 16's molecular function is recorded as transcription factor binding^[24].
Interferon gamma inducible protein 16's molecular function is recorded as protein binding^[25].
Interferon gamma inducible protein 16's molecular function is recorded as RNA binding^[26].

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Quick Facts

Instance of protein

Properties

Biological process positive regulation of type I interferon production, positive regulation of cytokine production, intrinsic apoptotic signaling pathway by p53 class mediator, cellular response to glucose starvation, transcription, DNA-templated, negative regulation of viral genome replication, negative regulation of innate immune response, monocyte differentiation, cellular response to ionizing radiation, negative regulation of DNA binding, regulation of autophagy, myeloid cell differentiation, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, apoptotic process, hemopoiesis, activation of cysteine-type endopeptidase activity, autophagy, negative regulation of cysteine-type endopeptidase activity, negative regulation of transcription by RNA polymerase II, positive regulation of interleukin-1 beta production, regulation of transcription, DNA-templated, regulation of gene expression, epigenetic, cell population proliferation, positive regulation of transcription by RNA polymerase II, activation of innate immune response, immune system process, inflammatory response, negative regulation of transcription, DNA-templated, innate immune response, defense response to virus, activation of innate immune response, cellular response to interferon-beta

Cell component nucleolus, nucleoplasm, nucleus, membrane, nuclear speck, cytoplasm, cytosol, cytosol, membrane

Encoded by IFI16

Found in taxon Homo sapiens

Imported from wholeness_audit_2026-05-02

Molecular function DNA-binding transcription repressor activity, RNA polymerase II-specific, identical protein binding, double-stranded DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA binding, transcription factor binding, protein binding, RNA binding, RNA binding

External References (4)

Ensembl protein id ENSP00000295809, ENSP00000352740, ENSP00000357113, ENSP00000357114, ENSP00000404325, ENSP00000342741, ENSP00000406406, ENSP00000407052, ENSP00000456094, ENSP00000456129, ENSP00000458084

Pdb structure id 2OQ0, 3B6Y, 3RLN, 3RLO, 3RNU, 4QGU

Refseq protein id NP_001193496, NP_005522, XP_016856639, NP_001351796, NP_001363516, NP_001363517, NP_001363518, NP_001363520, NP_001363521

Uniprot protein id Nanjing

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Interferon gamma inducible protein 16 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Interferon gamma inducible protein 16 — UniProt protein ID (P352): Nanjing. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Interferon gamma inducible protein 16 — RefSeq protein ID (P637): NP_001193496. Q20641742. Retrieved 2020-05-30. wikidata.org.
[5] ↑ Interferon gamma inducible protein 16 — RefSeq protein ID (P637): NP_005522. Q20641742. Retrieved 2020-05-30. wikidata.org.
[6] ↑ Interferon gamma inducible protein 16 — RefSeq protein ID (P637): XP_016856639. Q20641742. Retrieved 2020-05-30. wikidata.org.
[7] ↑ Interferon gamma inducible protein 16 — RefSeq protein ID (P637): NP_001351796. Q20641742. Retrieved 2020-05-30. wikidata.org.
[8] ↑ Interferon gamma inducible protein 16 — RefSeq protein ID (P637): NP_001363516. Q20641742. Retrieved 2020-05-30. wikidata.org.
[9] ↑ Interferon gamma inducible protein 16 — RefSeq protein ID (P637): NP_001363517. Q20641742. Retrieved 2020-05-30. wikidata.org.
[10] ↑ Interferon gamma inducible protein 16 — RefSeq protein ID (P637): NP_001363518. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ Interferon gamma inducible protein 16 — RefSeq protein ID (P637): NP_001363520. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ Interferon gamma inducible protein 16 — RefSeq protein ID (P637): NP_001363521. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ Interferon gamma inducible protein 16 — PDB structure ID (P638): 2OQ0. Q905695. Retrieved 2016-08-09. wikidata.org.
[14] ↑ Interferon gamma inducible protein 16 — PDB structure ID (P638): 3B6Y. Q905695. Retrieved 2016-08-09. wikidata.org.
[15] ↑ Interferon gamma inducible protein 16 — PDB structure ID (P638): 3RLN. Q905695. Retrieved 2016-08-09. wikidata.org.
[16] ↑ Interferon gamma inducible protein 16 — PDB structure ID (P638): 3RLO. Q905695. Retrieved 2016-08-09. wikidata.org.
[17] ↑ Interferon gamma inducible protein 16 — PDB structure ID (P638): 3RNU. Q905695. Retrieved 2016-08-09. wikidata.org.
[18] ↑ Interferon gamma inducible protein 16 — PDB structure ID (P638): 4QGU. Q905695. Retrieved 2016-08-09. wikidata.org.
[19] ↑ Interferon gamma inducible protein 16 — molecular function (P680): DNA-binding transcription repressor activity, RNA polymerase II-specific. Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1. Retrieved 2017-10-17. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Interferon gamma inducible protein 16 — molecular function (P680): identical protein binding. Human Cytomegalovirus Tegument Protein pUL83 Inhibits IFI16-Mediated DNA Sensing for Immune Evasion. Retrieved 2017-10-17. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Interferon gamma inducible protein 16 — molecular function (P680): double-stranded DNA binding. IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Interferon gamma inducible protein 16 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Interferon gamma inducible protein 16 — molecular function (P680): DNA binding. GOA. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Interferon gamma inducible protein 16 — molecular function (P680): transcription factor binding. Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Interferon gamma inducible protein 16 — molecular function (P680): protein binding. The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Interferon gamma inducible protein 16 — molecular function (P680): RNA binding. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Retrieved 2017-10-17. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Interferon gamma inducible protein 16 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_interferon-gamma-inducible-protein-16_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Interferon gamma inducible protein 16}}, year = {2026}, url = {https://4ort.xyz/entity/interferon-gamma-inducible-protein-16}, note = {Accessed: 2026-05-03}}

LLM prompt

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Canonical URL: https://4ort.xyz/entity/interferon-gamma-inducible-protein-16 · Last refreshed: May 3, 2026