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interferon alpha 2

mammalian protein found in Homo sapiens
Protein protein Q22677926

Facts

8 properties
Instance of
protein, protein fragment[2]
Part of
interferon type I, four-helical cytokine-like, core, prepro-interferon alpha-2[3][4][5]
Biological process
apoptotic process, defense response, negative regulation of viral entry into host cell, response to exogenous dsRNA, cell-cell signaling, negative regulation of T-helper 2 cell cytokine production, blood coagulation, positive regulation of peptidyl-serine phosphorylation of STAT protein, negative regulation of gene expression, positive regulation of transcription, DNA-templated, natural killer cell activation involved in immune response, cell surface receptor signaling pathway, B cell proliferation, humoral immune response, type I interferon signaling pathway, B cell differentiation, positive regulation of phosphorylation, inflammatory response, negative regulation of transcription, DNA-templated, negative regulation of T cell differentiation, T cell activation involved in immune response, defense response to virus, innate immune response, cytokine-mediated signaling pathway, positive regulation of tyrosine phosphorylation of STAT protein, regulation of signaling receptor activity, adaptive immune response[14][15][16][17][18][19][20][21][22][23][24][25][26][27]
Cell component
extracellular region, extracellular space, collagen-containing extracellular matrix[11][12][13]
Encoded by
IFNA2[28]
Found in taxon
Homo sapiens[29]
Molecular function
cytokine activity, type I interferon receptor binding, protein binding, cytokine receptor binding, type I interferon receptor binding[7][8][9][10]
Said to be the same as
interferon Alfa-2a, recombinant[6]
🏷️ Also known as
en alpha-2a interferon en IFNA2(24-188) en IFN-alpha-2 en interferon alpha 2 en interferon alpha-2 en interferon alpha 2a en interferon alpha 2b en interferon alpha A en Interferon alpha-A en Interferon-α2 en leIF A
🔖 Identifiers · 4
Exact match
www.uniprot.org
MeSH descriptor ID
D000077190
MeSH tree code
D12.644.276.374.440.890.250.500, D12.776.467.374.440.890.250.500, D23.529.374.440.890.250.500
PDB structure ID
1RH2, 3S9D, 1ITF, 2LAG, 4YPG, 2KZ1, 2HYM, 2LMS, 3SE3, 4Z5R

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Summary

interferon alpha 2 is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . wikidata.org.
  2. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . wikidata.org.
  6. [7] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [8] ↑ . At least three human type alpha interferons: structure of alpha 2. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . Recombinant IFN-alpha (2b) increases the expression of apoptosis receptor CD95 and chemokine receptors CCR1 and CCR3 in monocytoid cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . Recombinant IFN-alpha (2b) increases the expression of apoptosis receptor CD95 and chemokine receptors CCR1 and CCR3 in monocytoid cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] ↑ . HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] ↑ . At least three human type alpha interferons: structure of alpha 2. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [27] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [28] ↑ . UniProt. Retrieved . wikidata.org.
  28. [29] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). interferon alpha 2. Retrieved October 30, 2026, from https://4ort.xyz/entity/interferon-alpha-2
MLA “interferon alpha 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 30 Oct. 2026, https://4ort.xyz/entity/interferon-alpha-2.
BibTeX @misc{4ortxyz_interferon-alpha-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{interferon alpha 2}}, year = {2026}, url = {https://4ort.xyz/entity/interferon-alpha-2}, note = {Accessed: 2026-10-30}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 20w ago · MatSuBot bot · 2026-06-13 view diff on Wikidata ↗
    Part of → interferon type I, four-helical cytokine-like, core, prepro-interferon alpha-2
    Exact match → https://www.uniprot.org/uniprot/P01563#PRO_0000016360
    PDB structure ID → 1RH2, 3S9D, 1ITF +7
    Wikidata description → mammalian protein found in Homo sapiens
    + 10 other properties edited (see Wikidata diff for full list)
    "/* wbsetclaimvalue:1| */ Part of: interferon type I, fix redirect interferon alpha/beta/delta → interferon type I ([[:toollabs:editgroups/b/CB/e90e8a1319ef|details]])"
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