Insulin receptor substrate 1

mammalian protein found in Rattus norvegicus
Protein protein Q28556221
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Summary

Insulin receptor substrate 1 is a protein[1].

Key Facts

  • Insulin receptor substrate 1's instance of is recorded as protein[2].
  • Insulin receptor substrate 1's subclass of is recorded as protein[3].
  • Insulin receptor substrate 1's UniProt protein ID is recorded as P35570[4].
  • Insulin receptor substrate 1's RefSeq protein ID is recorded as NP_037101[5].
  • Insulin receptor substrate 1's molecular function is recorded as transmembrane receptor protein tyrosine kinase adaptor activity[6].
  • Insulin receptor substrate 1's molecular function is recorded as protein kinase C binding[7].
  • Insulin receptor substrate 1's molecular function is recorded as insulin receptor binding[8].
  • Insulin receptor substrate 1's molecular function is recorded as insulin-like growth factor receptor binding[9].
  • Insulin receptor substrate 1's molecular function is recorded as protein binding[10].
  • Insulin receptor substrate 1's molecular function is recorded as protein kinase binding[11].
  • Insulin receptor substrate 1's molecular function is recorded as protein domain specific binding[12].
  • Insulin receptor substrate 1's molecular function is recorded as SH2 domain binding[13].
  • Insulin receptor substrate 1's molecular function is recorded as phosphatidylinositol 3-kinase binding[14].
  • Insulin receptor substrate 1's cell component is recorded as nucleus[15].
  • Insulin receptor substrate 1's cell component is recorded as cytoplasm[16].
  • Insulin receptor substrate 1's cell component is recorded as cytosol[17].
  • Insulin receptor substrate 1's cell component is recorded as plasma membrane[18].
  • Insulin receptor substrate 1's cell component is recorded as insulin receptor complex[19].
  • Insulin receptor substrate 1's cell component is recorded as intracellular membrane-bounded organelle[20].
  • Insulin receptor substrate 1's biological process is recorded as signal transduction[21].
  • Insulin receptor substrate 1's biological process is recorded as ageing[22].
  • Insulin receptor substrate 1's biological process is recorded as insulin receptor signaling pathway[23].
  • Insulin receptor substrate 1's biological process is recorded as response to activity[24].
  • Insulin receptor substrate 1's biological process is recorded as response to caffeine[25].
  • Insulin receptor substrate 1's biological process is recorded as positive regulation of phosphorylation[26].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . UniProt. Retrieved . wikidata.org.
  2. [3] ↑ . UniProt. Retrieved . wikidata.org.
  3. [4] ↑ . UniProt. Retrieved . wikidata.org.
  4. [5] ↑ . Q20641742. Retrieved . wikidata.org.
  5. [6] ↑ . Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [7] ↑ . Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . Reduction of adiposity with prolonged growth hormone treatment in old obese rats: effects on glucose handling and early insulin signaling. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . Altered subcellular distribution of IRS-1 and IRS-3 is associated with defective Akt activation and GLUT4 translocation in insulin-resistant old rat adipocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . Effects of treadmill exercise and training frequency on anabolic signaling pathways in the skeletal muscle of aged rats. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] ↑ . Effects of treadmill exercise and training frequency on anabolic signaling pathways in the skeletal muscle of aged rats. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] ↑ . Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] ↑ . Blockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretion. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Insulin receptor substrate 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/insulin-receptor-substrate-1-q28556221
MLA “Insulin receptor substrate 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/insulin-receptor-substrate-1-q28556221.
BibTeX @misc{4ortxyz_insulin-receptor-substrate-1-q28556221_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Insulin receptor substrate 1}}, year = {2026}, url = {https://4ort.xyz/entity/insulin-receptor-substrate-1-q28556221}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Insulin receptor substrate 1 — https://4ort.xyz/entity/insulin-receptor-substrate-1-q28556221 (retrieved 2026-05-03)

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