Insulin receptor substrate 1

mammalian protein found in Mus musculus

Protein protein Q15334111

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Summary

Insulin receptor substrate 1 is a protein^[1].

Key Facts

Insulin receptor substrate 1's instance of is recorded as protein^[2].
Insulin receptor substrate 1's subclass of is recorded as protein^[3].
Insulin receptor substrate 1's UniProt protein ID is recorded as P35569^[4].
Insulin receptor substrate 1's RefSeq protein ID is recorded as NP_034700^[5].
Insulin receptor substrate 1's PDB structure ID is recorded as 1AYB^[6].
Insulin receptor substrate 1's PDB structure ID is recorded as 5AXI^[7].
Insulin receptor substrate 1's molecular function is recorded as insulin-like growth factor receptor binding^[8].
Insulin receptor substrate 1's molecular function is recorded as signal transducer activity^[9].
Insulin receptor substrate 1's molecular function is recorded as phosphatidylinositol 3-kinase binding^[10].
Insulin receptor substrate 1's molecular function is recorded as protein binding^[11].
Insulin receptor substrate 1's molecular function is recorded as phosphotyrosine residue binding^[12].
Insulin receptor substrate 1's molecular function is recorded as insulin receptor binding^[13].
Insulin receptor substrate 1's molecular function is recorded as transmembrane receptor protein tyrosine kinase adaptor activity^[14].
Insulin receptor substrate 1's molecular function is recorded as protein kinase C binding^[15].
Insulin receptor substrate 1's molecular function is recorded as protein kinase binding^[16].
Insulin receptor substrate 1's molecular function is recorded as protein domain specific binding^[17].
Insulin receptor substrate 1's molecular function is recorded as SH2 domain binding^[18].
Insulin receptor substrate 1's molecular function is recorded as insulin receptor binding^[19].
Insulin receptor substrate 1's molecular function is recorded as phosphatidylinositol 3-kinase binding^[20].
Insulin receptor substrate 1's cell component is recorded as cytoplasm^[21].
Insulin receptor substrate 1's cell component is recorded as ciliary basal body^[22].
Insulin receptor substrate 1's cell component is recorded as caveola^[23].
Insulin receptor substrate 1's cell component is recorded as nucleus^[24].
Insulin receptor substrate 1's cell component is recorded as cytosol^[25].
Insulin receptor substrate 1's cell component is recorded as plasma membrane^[26].

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Quick Facts

Instance of protein

Subclass of protein

Properties

Biological process positive regulation of fatty acid beta-oxidation, insulin receptor signaling pathway, positive regulation of glucose import, insulin-like growth factor receptor signaling pathway, negative regulation of insulin secretion, positive regulation of glycogen biosynthetic process, protein kinase B signaling, positive regulation of cell migration, insulin secretion, positive regulation of glucose metabolic process, mammary gland development, lipid catabolic process, response to insulin, positive regulation of mesenchymal cell proliferation, cellular response to insulin stimulus, protein localization to nucleus, regulation of gene expression, phosphatidylinositol 3-kinase signaling, signal transduction, response to caffeine, positive regulation of phosphorylation, response to peptide hormone, positive regulation of phosphatidylinositol 3-kinase activity, negative regulation of insulin receptor signaling pathway, positive regulation of insulin receptor signaling pathway, protein heterooligomerization, positive regulation of glucagon secretion, negative regulation of somatostatin secretion, cellular response to angiotensin, insulin receptor signaling pathway

Cell component cytoplasm, ciliary basal body, caveola, nucleus, cytosol, plasma membrane, insulin receptor complex, intracellular membrane-bounded organelle, plasma membrane

Encoded by Irs1

Found in taxon house mouse

Imported from wholeness_audit_2026-05-02

Molecular function insulin-like growth factor receptor binding, signal transducer activity, phosphatidylinositol 3-kinase binding, protein binding, phosphotyrosine residue binding, insulin receptor binding, transmembrane receptor protein tyrosine kinase adaptor activity, protein kinase C binding, protein kinase binding, protein domain specific binding, SH2 domain binding, insulin receptor binding, phosphatidylinositol 3-kinase binding

External References (4)

Ensembl protein id ENSMUSP00000063795

Pdb structure id 1AYB, 5AXI

Refseq protein id NP_034700

Uniprot protein id P35569

🏷️ Also known as

en Insulin receptor substrate 1 en Irs1 en uniprot:P35569

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Insulin receptor substrate 1 — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Insulin receptor substrate 1 — subclass of (P279): protein. UniProt. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Insulin receptor substrate 1 — UniProt protein ID (P352): P35569. UniProt. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Insulin receptor substrate 1 — RefSeq protein ID (P637): NP_034700. Q20641742. Retrieved 2022-03-20. wikidata.org.
[6] ↑ Insulin receptor substrate 1 — PDB structure ID (P638): 1AYB. UniProt. Retrieved 2016-08-10. wikidata.org.
[7] ↑ Insulin receptor substrate 1 — PDB structure ID (P638): 5AXI. UniProt. Retrieved 2016-08-10. wikidata.org.
[8] ↑ Insulin receptor substrate 1 — molecular function (P680): insulin-like growth factor receptor binding. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Insulin receptor substrate 1 — molecular function (P680): signal transducer activity. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Insulin receptor substrate 1 — molecular function (P680): phosphatidylinositol 3-kinase binding. GOA. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Insulin receptor substrate 1 — molecular function (P680): protein binding. Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Insulin receptor substrate 1 — molecular function (P680): phosphotyrosine residue binding. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Insulin receptor substrate 1 — molecular function (P680): insulin receptor binding. GOA. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Insulin receptor substrate 1 — molecular function (P680): transmembrane receptor protein tyrosine kinase adaptor activity. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Insulin receptor substrate 1 — molecular function (P680): protein kinase C binding. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Insulin receptor substrate 1 — molecular function (P680): protein kinase binding. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Insulin receptor substrate 1 — molecular function (P680): protein domain specific binding. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Insulin receptor substrate 1 — molecular function (P680): SH2 domain binding. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Insulin receptor substrate 1 — molecular function (P680): insulin receptor binding. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Insulin receptor substrate 1 — molecular function (P680): phosphatidylinositol 3-kinase binding. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Insulin receptor substrate 1 — cell component (P681): cytoplasm. Intracellular redistribution of nuclear and nucleolar proteins during differentiation of 32D murine hemopoietic cells. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Insulin receptor substrate 1 — cell component (P681): ciliary basal body. Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Insulin receptor substrate 1 — cell component (P681): caveola. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Insulin receptor substrate 1 — cell component (P681): nucleus. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Insulin receptor substrate 1 — cell component (P681): cytosol. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Insulin receptor substrate 1 — cell component (P681): plasma membrane. GOA. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Insulin receptor substrate 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Insulin receptor substrate 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/insulin-receptor-substrate-1-q15334111

MLA

“Insulin receptor substrate 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/insulin-receptor-substrate-1-q15334111.

BibTeX

@misc{4ortxyz_insulin-receptor-substrate-1-q15334111_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Insulin receptor substrate 1}}, year = {2026}, url = {https://4ort.xyz/entity/insulin-receptor-substrate-1-q15334111}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Insulin receptor substrate 1 — https://4ort.xyz/entity/insulin-receptor-substrate-1-q15334111 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/insulin-receptor-substrate-1-q15334111 · Last refreshed: May 3, 2026