Insulin receptor

mammalian protein found in Mus musculus

Protein protein Q14863366

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Insulin receptor

Summary

Insulin receptor is a protein^[1].

Key Facts

Insulin receptor's instance of is recorded as protein^[2].
Insulin receptor's UniProt protein ID is recorded as P15208^[3].
Insulin receptor's part of is recorded as Immunoglobulin-like fold^[4].
Insulin receptor's part of is recorded as Protein kinase-like domain superfamily^[5].
Insulin receptor's part of is recorded as tyrosine-protein kinase, insulin-like receptor^[6].
Insulin receptor's part of is recorded as Fibronectin type III superfamily^[7].
Insulin receptor's part of is recorded as Growth factor receptor cysteine-rich domain superfamily^[8].
Insulin receptor's part of is recorded as Receptor L-domain superfamily^[9].
Insulin receptor's part of is recorded as membrane protein^[10].
Insulin receptor's part of is recorded as Fibronectin type III, protein family^[11].
Insulin receptor's part of is recorded as Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[12].
Insulin receptor's part of is recorded as Receptor L-domain, protein family^[13].
Insulin receptor's part of is recorded as Furin-like cysteine-rich domain, protein family^[14].
Insulin receptor's part of is recorded as Protein kinase domain, protein family^[15].
Insulin receptor's part of is recorded as Protein kinase, ATP binding site, protein family^[16].
Insulin receptor's part of is recorded as Tyrosine-protein kinase, catalytic domain, protein family^[17].
Insulin receptor's part of is recorded as Tyrosine-protein kinase, receptor class II, conserved site, protein family^[18].
Insulin receptor's part of is recorded as Tyrosine-protein kinase, active site, protein family^[19].
Insulin receptor's part of is recorded as Furin-like repeat, protein family^[20].
Insulin receptor's has part is recorded as fibronectin type III^[21].
Insulin receptor's has part is recorded as Furin-like repeat^[22].
Insulin receptor's has part is recorded as tyrosine-protein kinase, active site^[23].
Insulin receptor's has part is recorded as tyrosine-protein kinase, catalytic domain^[24].
Insulin receptor's has part is recorded as serine-threonine/tyrosine-protein kinase, catalytic domain^[25].
Insulin receptor's has part is recorded as Receptor L-domain^[26].

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Quick Facts

Instance of protein

Part of Immunoglobulin-like fold, Protein kinase-like domain superfamily, tyrosine-protein kinase, insulin-like receptor, Fibronectin type III superfamily, Growth factor receptor cysteine-rich domain superfamily, Receptor L-domain superfamily, membrane protein, Fibronectin type III, protein family, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, Receptor L-domain, protein family, Furin-like cysteine-rich domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, receptor class II, conserved site, protein family, Tyrosine-protein kinase, active site, protein family, Furin-like repeat, protein family

Properties

Biological process positive regulation of glucose import, insulin receptor signaling pathway, positive regulation of protein phosphorylation, regulation of embryonic development, positive regulation of developmental growth, protein heterotetramerization, regulation of female gonad development, animal organ morphogenesis, transformation of host cell by virus, positive regulation of mitotic nuclear division, positive regulation of meiotic cell cycle, positive regulation of protein kinase B signaling, positive regulation of glycogen biosynthetic process, regulation of transcription, DNA-templated, glucose homeostasis, transmembrane receptor protein tyrosine kinase signaling pathway, male sex determination, positive regulation of transcription, DNA-templated, epidermis development, cellular response to insulin stimulus, protein autophosphorylation, positive regulation of respiratory burst, positive regulation of MAPK cascade, exocrine pancreas development, G protein-coupled receptor signaling pathway, male gonad development, phosphorylation, peptidyl-tyrosine autophosphorylation, activation of protein kinase B activity, positive regulation of cell migration, positive regulation of nitric oxide biosynthetic process, cellular response to growth factor stimulus, heart morphogenesis, adrenal gland development, positive regulation of cell population proliferation, peptidyl-tyrosine phosphorylation, positive regulation of glycolytic process, activation of protein kinase activity, signal transduction, intracellular signal transduction, negative regulation of protein phosphorylation, protein phosphorylation, regulation of hydrogen peroxide metabolic process, positive regulation of glycoprotein biosynthetic process, negative regulation of gene expression, negative regulation of transporter activity, response to tumor necrosis factor, positive regulation of phosphorylation, positive regulation of protein-containing complex disassembly, dendritic spine maintenance, amyloid-beta clearance, neuron projection maintenance, negative regulation of signal transduction, cell differentiation, glucose homeostasis, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of MAPK cascade, anatomical structure development, positive regulation of protein kinase B signaling, receptor-mediated endocytosis

Cell component membrane, caveola, insulin receptor complex, integral component of membrane, receptor complex, integral component of plasma membrane, nuclear envelope, nuclear lumen, amyloid-beta complex, intracellular anatomical structure, nucleus, endosome, cytosol, plasma membrane, external side of plasma membrane, dendrite membrane, neuronal cell body membrane, soma, intracellular membrane-bounded organelle, synapse, cytoplasm, integral component of plasma membrane, insulin receptor complex, axon, receptor complex

Encoded by Insr

Found in taxon house mouse

Has part(s) fibronectin type III, Furin-like repeat, tyrosine-protein kinase, active site, tyrosine-protein kinase, catalytic domain, serine-threonine/tyrosine-protein kinase, catalytic domain, Receptor L-domain, protein kinase, ATP binding site, tyrosine-protein kinase, receptor class II, conserved site, Furin-like cysteine-rich domain, protein kinase domain

Imported from wholeness_audit_2026-05-02

Molecular function kinase activity, insulin-like growth factor II binding, transmembrane receptor protein tyrosine kinase activity, ATP binding, insulin-like growth factor receptor binding, insulin binding, insulin receptor substrate binding, transferase activity, protein binding, insulin-activated receptor activity, protein tyrosine kinase activity, nucleotide binding, insulin-like growth factor I binding, GTP binding, PTB domain binding, phosphatidylinositol 3-kinase binding, protein domain specific binding, amyloid-beta binding, identical protein binding, protein-containing complex binding, protein kinase activity, protein kinase binding, protein phosphatase binding, lipoic acid binding, 3-phosphoinositide-dependent protein kinase binding, receptor tyrosine kinase, transmembrane signaling receptor activity, insulin-activated receptor activity, insulin receptor substrate binding, transmembrane receptor protein tyrosine kinase activity, cargo receptor activity

External References (4)

Ensembl protein id ENSMUSP00000088837, ENSMUSP00000146651, ENSMUSP00000146818

Pdb structure id 1LK2

Refseq protein id NP_001316985, NP_034698, XP_006508763, XP_006508764

Uniprot protein id P15208

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Insulin receptor — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Insulin receptor — UniProt protein ID (P352): P15208. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Insulin receptor — part of (P361): Immunoglobulin-like fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Insulin receptor — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Insulin receptor — part of (P361): tyrosine-protein kinase, insulin-like receptor. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Insulin receptor — part of (P361): Fibronectin type III superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Insulin receptor — part of (P361): Growth factor receptor cysteine-rich domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Insulin receptor — part of (P361): Receptor L-domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Insulin receptor — part of (P361): membrane protein. wikidata.org.
[11] ↑ Insulin receptor — part of (P361): Fibronectin type III, protein family. wikidata.org.
[12] ↑ Insulin receptor — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[13] ↑ Insulin receptor — part of (P361): Receptor L-domain, protein family. wikidata.org.
[14] ↑ Insulin receptor — part of (P361): Furin-like cysteine-rich domain, protein family. wikidata.org.
[15] ↑ Insulin receptor — part of (P361): Protein kinase domain, protein family. wikidata.org.
[16] ↑ Insulin receptor — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[17] ↑ Insulin receptor — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[18] ↑ Insulin receptor — part of (P361): Tyrosine-protein kinase, receptor class II, conserved site, protein family. wikidata.org.
[19] ↑ Insulin receptor — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[20] ↑ Insulin receptor — part of (P361): Furin-like repeat, protein family. wikidata.org.
[21] ↑ Insulin receptor — has part(s) (P527): fibronectin type III. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Insulin receptor — has part(s) (P527): Furin-like repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Insulin receptor — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Insulin receptor — has part(s) (P527): tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Insulin receptor — has part(s) (P527): serine-threonine/tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Insulin receptor — has part(s) (P527): Receptor L-domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Insulin receptor is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Insulin receptor. Retrieved May 3, 2026, from https://4ort.xyz/entity/insulin-receptor-q14863366

MLA

“Insulin receptor.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/insulin-receptor-q14863366.

BibTeX

@misc{4ortxyz_insulin-receptor-q14863366_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Insulin receptor}}, year = {2026}, url = {https://4ort.xyz/entity/insulin-receptor-q14863366}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Insulin receptor — https://4ort.xyz/entity/insulin-receptor-q14863366 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/insulin-receptor-q14863366 · Last refreshed: May 3, 2026