insulin like growth factor 1 receptor

mammalian protein found in Homo sapiens

Protein protein Q2005209

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insulin like growth factor 1 receptor

Summary

insulin like growth factor 1 receptor is a protein^[1].

Key Facts

insulin like growth factor 1 receptor's instance of is recorded as protein^[2].
insulin like growth factor 1 receptor's physically interacts with is recorded as ceritinib^[3].
insulin like growth factor 1 receptor's physically interacts with is recorded as AP-26113^[4].
insulin like growth factor 1 receptor's physically interacts with is recorded as bms-754807^[5].
insulin like growth factor 1 receptor's physically interacts with is recorded as picropodophyllin^[6].
insulin like growth factor 1 receptor is part of Immunoglobulin-like fold^[7].
insulin like growth factor 1 receptor is part of Protein kinase-like domain superfamily^[8].
insulin like growth factor 1 receptor is part of tyrosine-protein kinase, insulin-like receptor^[9].
insulin like growth factor 1 receptor is part of Fibronectin type III superfamily^[10].
insulin like growth factor 1 receptor is part of Growth factor receptor cysteine-rich domain superfamily^[11].
insulin like growth factor 1 receptor is part of Receptor L-domain superfamily^[12].
insulin like growth factor 1 receptor is part of Fibronectin type III, protein family^[13].
insulin like growth factor 1 receptor is part of Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[14].
insulin like growth factor 1 receptor is part of Receptor L-domain, protein family^[15].
insulin like growth factor 1 receptor is part of Furin-like cysteine-rich domain, protein family^[16].
insulin like growth factor 1 receptor is part of Protein kinase domain, protein family^[17].
insulin like growth factor 1 receptor is part of Protein kinase, ATP binding site, protein family^[18].
insulin like growth factor 1 receptor is part of Tyrosine-protein kinase, catalytic domain, protein family^[19].
insulin like growth factor 1 receptor is part of Tyrosine-protein kinase, receptor class II, conserved site, protein family^[20].
insulin like growth factor 1 receptor is part of Tyrosine-protein kinase, active site, protein family^[21].
insulin like growth factor 1 receptor is part of Furin-like repeat, protein family^[22].
insulin like growth factor 1 receptor comprises tyrosine-protein kinase, active site^[23].
insulin like growth factor 1 receptor comprises fibronectin type III^[24].
insulin like growth factor 1 receptor comprises protein kinase, ATP binding site^[25].
insulin like growth factor 1 receptor comprises protein kinase domain^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of Immunoglobulin-like fold, Protein kinase-like domain superfamily, tyrosine-protein kinase, insulin-like receptor, Fibronectin type III superfamily, Growth factor receptor cysteine-rich domain superfamily, Receptor L-domain superfamily, Fibronectin type III, protein family, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, Receptor L-domain, protein family, Furin-like cysteine-rich domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, receptor class II, conserved site, protein family, Tyrosine-protein kinase, active site, protein family, Furin-like repeat, protein family

Properties

Biological process insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of cell migration, negative regulation of apoptotic process, protein tetramerization, positive regulation of DNA replication, protein phosphorylation, regulation of JNK cascade, immune response, positive regulation of cell population proliferation, peptidyl-tyrosine autophosphorylation, protein autophosphorylation, phosphatidylinositol 3-kinase signaling, phosphatidylinositol-mediated signaling, signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of cell population proliferation, insulin receptor signaling pathway, positive regulation of phosphatidylinositol 3-kinase signaling, glucose homeostasis, positive regulation of protein-containing complex disassembly, positive regulation of MAPK cascade, regulation of JNK cascade, insulin-like growth factor receptor signaling pathway, anatomical structure development, positive regulation of protein kinase B signaling, cellular response to glucose stimulus, dendritic spine maintenance, amyloid-beta clearance, positive regulation of cold-induced thermogenesis, cellular response to amyloid-beta

Cell component integral component of membrane, membrane, intracellular membrane-bounded organelle, receptor complex, plasma membrane, integral component of plasma membrane, alphav-beta3 integrin-IGF-1-IGF1R complex, integral component of plasma membrane, insulin receptor complex, axon, receptor complex

Ec enzyme number 2.7.10.1

Encoded by IGF1R

Found in taxon Homo sapiens

Has part(s) tyrosine-protein kinase, active site, fibronectin type III, protein kinase, ATP binding site, protein kinase domain, tyrosine-protein kinase, catalytic domain, Receptor L-domain, serine-threonine/tyrosine-protein kinase, catalytic domain, Furin-like cysteine-rich domain, Furin-like repeat, tyrosine-protein kinase, receptor class II, conserved site

Molecular function transferase activity, nucleotide binding, protein kinase activity, insulin-like growth factor binding, insulin receptor binding, insulin binding, kinase activity, phosphatidylinositol 3-kinase binding, insulin-like growth factor-activated receptor activity, protein binding, identical protein binding, transmembrane receptor protein tyrosine kinase activity, insulin receptor substrate binding, protein tyrosine kinase activity, ATP binding, insulin-like growth factor I binding, transmembrane receptor protein tyrosine kinase activity, insulin-activated receptor activity, insulin receptor substrate binding

Physically interacts with ceritinib, AP-26113, bms-754807, picropodophyllin

External References (6)

Ensembl protein id ENSP00000453630, ENSP00000454115, ENSP00000456950, ENSP00000497069, ENSP00000496919

Mesh descriptor id D017526

Mesh tree code D08.811.913.696.620.682.725.400.185, D12.776.543.750.630.468, D12.776.543.750.750.400.780.400, D12.776.476.568.400.185

Pdb structure id 1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU, 4D2R, 4XSS, 5HZN

Refseq protein id NP_000866, NP_001278787, XP_011519818, XP_011519819, XP_016877625, XP_016877626, XP_016877627, XP_016877628, XP_024305681

Uniprot protein id P08069

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ insulin like growth factor 1 receptor — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ insulin like growth factor 1 receptor — physically interacts with (P129): ceritinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ insulin like growth factor 1 receptor — physically interacts with (P129): AP-26113. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[5] ↑ insulin like growth factor 1 receptor — physically interacts with (P129): bms-754807. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[6] ↑ insulin like growth factor 1 receptor — physically interacts with (P129): picropodophyllin. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[7] ↑ insulin like growth factor 1 receptor — part of (P361): Immunoglobulin-like fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ insulin like growth factor 1 receptor — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ insulin like growth factor 1 receptor — part of (P361): tyrosine-protein kinase, insulin-like receptor. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ insulin like growth factor 1 receptor — part of (P361): Fibronectin type III superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ insulin like growth factor 1 receptor — part of (P361): Growth factor receptor cysteine-rich domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ insulin like growth factor 1 receptor — part of (P361): Receptor L-domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ insulin like growth factor 1 receptor — part of (P361): Fibronectin type III, protein family. wikidata.org.
[14] ↑ insulin like growth factor 1 receptor — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[15] ↑ insulin like growth factor 1 receptor — part of (P361): Receptor L-domain, protein family. wikidata.org.
[16] ↑ insulin like growth factor 1 receptor — part of (P361): Furin-like cysteine-rich domain, protein family. wikidata.org.
[17] ↑ insulin like growth factor 1 receptor — part of (P361): Protein kinase domain, protein family. wikidata.org.
[18] ↑ insulin like growth factor 1 receptor — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[19] ↑ insulin like growth factor 1 receptor — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[20] ↑ insulin like growth factor 1 receptor — part of (P361): Tyrosine-protein kinase, receptor class II, conserved site, protein family. wikidata.org.
[21] ↑ insulin like growth factor 1 receptor — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[22] ↑ insulin like growth factor 1 receptor — part of (P361): Furin-like repeat, protein family. wikidata.org.
[23] ↑ insulin like growth factor 1 receptor — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ insulin like growth factor 1 receptor — has part(s) (P527): fibronectin type III. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ insulin like growth factor 1 receptor — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ insulin like growth factor 1 receptor — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ insulin like growth factor 1 receptor is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). insulin like growth factor 1 receptor. Retrieved May 3, 2026, from https://4ort.xyz/entity/insulin-like-growth-factor-1-receptor-q2005209

MLA

“insulin like growth factor 1 receptor.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/insulin-like-growth-factor-1-receptor-q2005209.

BibTeX

@misc{4ortxyz_insulin-like-growth-factor-1-receptor-q2005209_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{insulin like growth factor 1 receptor}}, year = {2026}, url = {https://4ort.xyz/entity/insulin-like-growth-factor-1-receptor-q2005209}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): insulin like growth factor 1 receptor — https://4ort.xyz/entity/insulin-like-growth-factor-1-receptor-q2005209 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/insulin-like-growth-factor-1-receptor-q2005209 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

4w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → P08069

Imported from → —

Mesh descriptor id → D017526

Ensembl protein id → ENSP00000453630, ENSP00000454115, ENSP00000456950 +2

+ 15 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.10.1, [[:toollabs:quickstatements/#/batch/261446|batch #261446]]"

Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.