hypoxia inducible factor 1 subunit alpha

mammalian protein found in Homo sapiens

Protein protein Q5629645

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hypoxia inducible factor 1 subunit alpha

Summary

hypoxia inducible factor 1 subunit alpha is a protein^[1].

Key Facts

hypoxia inducible factor 1 subunit alpha's instance of is recorded as protein^[2].
hypoxia inducible factor 1 subunit alpha's UniProt protein ID is recorded as Almonte^[3].
hypoxia inducible factor 1 subunit alpha's part of is recorded as hypoxia-inducible factor-1 alpha^[4].
hypoxia inducible factor 1 subunit alpha's part of is recorded as PAS domain superfamily^[5].
hypoxia inducible factor 1 subunit alpha's part of is recorded as Helix-loop-helix DNA-binding domain superfamily^[6].
hypoxia inducible factor 1 subunit alpha's part of is recorded as Myc-type, basic helix-loop-helix (bHLH) domain, protein family^[7].
hypoxia inducible factor 1 subunit alpha's part of is recorded as HIF-1 alpha, transactivation domain, C-terminal domain, protein family^[8].
hypoxia inducible factor 1 subunit alpha's part of is recorded as PAS fold family^[9].
hypoxia inducible factor 1 subunit alpha's part of is recorded as PAS fold-3 domain, protein family^[10].
hypoxia inducible factor 1 subunit alpha's part of is recorded as PAC motif domain, protein family^[11].
hypoxia inducible factor 1 subunit alpha's part of is recorded as PAS domain, protein family^[12].
hypoxia inducible factor 1 subunit alpha's MeSH descriptor ID is recorded as C497442^[13].
hypoxia inducible factor 1 subunit alpha's has part is recorded as PAS fold^[14].
hypoxia inducible factor 1 subunit alpha's has part is recorded as PAC motif^[15].
hypoxia inducible factor 1 subunit alpha's has part is recorded as PAS fold-3^[16].
hypoxia inducible factor 1 subunit alpha's has part is recorded as HIF-1 alpha, transactivation domain, C-terminal^[17].
hypoxia inducible factor 1 subunit alpha's has part is recorded as PAS domain^[18].
hypoxia inducible factor 1 subunit alpha's has part is recorded as Myc-type, basic helix-loop-helix (bHLH) domain^[19].
hypoxia inducible factor 1 subunit alpha's RefSeq protein ID is recorded as NP_001230013^[20].
hypoxia inducible factor 1 subunit alpha's RefSeq protein ID is recorded as NP_001521^[21].
hypoxia inducible factor 1 subunit alpha's RefSeq protein ID is recorded as NP_851397^[22].
hypoxia inducible factor 1 subunit alpha's PDB structure ID is recorded as 1H2K^[23].
hypoxia inducible factor 1 subunit alpha's PDB structure ID is recorded as 1H2L^[24].
hypoxia inducible factor 1 subunit alpha's PDB structure ID is recorded as 1H2M^[25].
hypoxia inducible factor 1 subunit alpha's PDB structure ID is recorded as 1L3E^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of hypoxia-inducible factor-1 alpha, PAS domain superfamily, Helix-loop-helix DNA-binding domain superfamily, Myc-type, basic helix-loop-helix (bHLH) domain, protein family, HIF-1 alpha, transactivation domain, C-terminal domain, protein family, PAS fold family, PAS fold-3 domain, protein family, PAC motif domain, protein family, PAS domain, protein family

Properties

Biological process negative regulation of neuron apoptotic process, B-1 B cell homeostasis, regulation of transforming growth factor beta2 production, muscle cell cellular homeostasis, outflow tract morphogenesis, negative regulation of ossification, heart looping, negative regulation of TOR signaling, blood vessel development, hemoglobin biosynthetic process, angiogenesis, positive regulation of chemokine-mediated signaling pathway, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of hormone biosynthetic process, negative regulation of mesenchymal cell apoptotic process, regulation of aerobic respiration, positive regulation of neuroblast proliferation, dopaminergic neuron differentiation, lactate metabolic process, regulation of transcription, DNA-templated, blood vessel morphogenesis, positive regulation of erythrocyte differentiation, glucose homeostasis, vascular endothelial growth factor production, regulation of thymocyte apoptotic process, positive regulation of epithelial cell migration, negative regulation of thymocyte apoptotic process, transcription, DNA-templated, positive regulation of transcription, DNA-templated, axonal transport of mitochondrion, positive regulation of macroautophagy, cartilage development, positive regulation of nitric-oxide synthase activity, regulation of transcription from RNA polymerase II promoter in response to hypoxia, lactation, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, positive regulation of pri-miRNA transcription by RNA polymerase II, digestive tract morphogenesis, cell differentiation, neural fold elevation formation, positive regulation of autophagy, retina vasculature development in camera-type eye, collagen metabolic process, embryonic placenta development, negative regulation of apoptotic process, positive regulation of angiogenesis, regulation of glycolytic process, epithelial to mesenchymal transition, cerebral cortex development, regulation of gene expression, positive regulation of chemokine production, intestinal epithelial cell maturation, regulation of catalytic activity, positive regulation of autophagy of mitochondrion, cardiac ventricle morphogenesis, response to muscle activity, epithelial cell differentiation involved in mammary gland alveolus development, visual learning, positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of bone mineralization, negative regulation of growth, response to hypoxia, positive regulation of endothelial cell proliferation, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, iris morphogenesis, mRNA transcription by RNA polymerase II, hypoxia-inducible factor-1alpha signaling pathway, vasculature development, regulation of cell population proliferation, neural crest cell migration, embryonic hemopoiesis, connective tissue replacement involved in inflammatory response wound healing, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, negative regulation of reactive oxygen species metabolic process, positive regulation of vascular endothelial growth factor production, elastin metabolic process, positive regulation of glycolytic process, oxygen homeostasis, signal transduction, positive regulation of transcription by RNA polymerase II, cellular iron ion homeostasis, camera-type eye morphogenesis, cellular response to hypoxia, cellular response to interleukin-1, transcription by RNA polymerase II, protein deubiquitination, post-translational protein modification, response to iron ion, negative regulation of gene expression, positive regulation of blood vessel endothelial cell migration, positive regulation of gene expression, cytokine-mediated signaling pathway, regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, protein ubiquitination, positive regulation of pri-miRNA transcription by RNA polymerase II

Cell component cytoplasm, cytosol, nucleus, nuclear speck, motile cilium, transcription regulator complex, RNA polymerase II transcription regulator complex, axon cytoplasm, nucleoplasm, nuclear body, protein-containing complex, nucleus

Encoded by HIF1A

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Has part(s) PAS fold, PAC motif, PAS fold-3, HIF-1 alpha, transactivation domain, C-terminal, PAS domain, Myc-type, basic helix-loop-helix (bHLH) domain

Imported from wholeness_audit_2026-05-02

Molecular function protein dimerization activity, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, histone deacetylase binding, transcription factor binding, enzyme binding, protein binding, histone acetyltransferase binding, protein kinase binding, Hsp90 protein binding, sequence-specific DNA binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, ubiquitin protein ligase binding, protein heterodimerization activity, E-box binding, p53 binding, protein domain specific binding, DNA-binding transcription factor activity, RNA polymerase II-specific, protein heterodimerization activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific

External References (6)

Ensembl protein id ENSP00000323326, ENSP00000338018, ENSP00000437955, ENSP00000378446

Mesh descriptor id C497442

Nalt id 215149

Pdb structure id 1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J

Refseq protein id NP_001230013, NP_001521, NP_851397

Uniprot protein id Almonte

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ hypoxia inducible factor 1 subunit alpha — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ hypoxia inducible factor 1 subunit alpha — UniProt protein ID (P352): Almonte. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ hypoxia inducible factor 1 subunit alpha — part of (P361): hypoxia-inducible factor-1 alpha. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ hypoxia inducible factor 1 subunit alpha — part of (P361): PAS domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ hypoxia inducible factor 1 subunit alpha — part of (P361): Helix-loop-helix DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ hypoxia inducible factor 1 subunit alpha — part of (P361): Myc-type, basic helix-loop-helix (bHLH) domain, protein family. wikidata.org.
[8] ↑ hypoxia inducible factor 1 subunit alpha — part of (P361): HIF-1 alpha, transactivation domain, C-terminal domain, protein family. wikidata.org.
[9] ↑ hypoxia inducible factor 1 subunit alpha — part of (P361): PAS fold family. wikidata.org.
[10] ↑ hypoxia inducible factor 1 subunit alpha — part of (P361): PAS fold-3 domain, protein family. wikidata.org.
[11] ↑ hypoxia inducible factor 1 subunit alpha — part of (P361): PAC motif domain, protein family. wikidata.org.
[12] ↑ hypoxia inducible factor 1 subunit alpha — part of (P361): PAS domain, protein family. wikidata.org.
[13] ↑ hypoxia inducible factor 1 subunit alpha — MeSH descriptor ID (P486): C497442. wikidata.org.
[14] ↑ hypoxia inducible factor 1 subunit alpha — has part(s) (P527): PAS fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ hypoxia inducible factor 1 subunit alpha — has part(s) (P527): PAC motif. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ hypoxia inducible factor 1 subunit alpha — has part(s) (P527): PAS fold-3. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ hypoxia inducible factor 1 subunit alpha — has part(s) (P527): HIF-1 alpha, transactivation domain, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ hypoxia inducible factor 1 subunit alpha — has part(s) (P527): PAS domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ hypoxia inducible factor 1 subunit alpha — has part(s) (P527): Myc-type, basic helix-loop-helix (bHLH) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ hypoxia inducible factor 1 subunit alpha — RefSeq protein ID (P637): NP_001230013. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ hypoxia inducible factor 1 subunit alpha — RefSeq protein ID (P637): NP_001521. Q20641742. Retrieved 2020-05-30. wikidata.org.
[22] ↑ hypoxia inducible factor 1 subunit alpha — RefSeq protein ID (P637): NP_851397. Q20641742. Retrieved 2020-05-30. wikidata.org.
[23] ↑ hypoxia inducible factor 1 subunit alpha — PDB structure ID (P638): 1H2K. Q905695. Retrieved 2016-08-04. wikidata.org.
[24] ↑ hypoxia inducible factor 1 subunit alpha — PDB structure ID (P638): 1H2L. Q905695. Retrieved 2016-08-04. wikidata.org.
[25] ↑ hypoxia inducible factor 1 subunit alpha — PDB structure ID (P638): 1H2M. Q905695. Retrieved 2016-08-04. wikidata.org.
[26] ↑ hypoxia inducible factor 1 subunit alpha — PDB structure ID (P638): 1L3E. Q905695. Retrieved 2016-08-04. wikidata.org.

Class ancestry

[1] ↑ hypoxia inducible factor 1 subunit alpha is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). hypoxia inducible factor 1 subunit alpha. Retrieved May 3, 2026, from https://4ort.xyz/entity/hypoxia-inducible-factor-1-subunit-alpha-q5629645

MLA

“hypoxia inducible factor 1 subunit alpha.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/hypoxia-inducible-factor-1-subunit-alpha-q5629645.

BibTeX

@misc{4ortxyz_hypoxia-inducible-factor-1-subunit-alpha-q5629645_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{hypoxia inducible factor 1 subunit alpha}}, year = {2026}, url = {https://4ort.xyz/entity/hypoxia-inducible-factor-1-subunit-alpha-q5629645}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): hypoxia inducible factor 1 subunit alpha — https://4ort.xyz/entity/hypoxia-inducible-factor-1-subunit-alpha-q5629645 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/hypoxia-inducible-factor-1-subunit-alpha-q5629645 · Last refreshed: May 3, 2026