Hypoxia inducible factor 1, alpha subunit

mammalian protein found in Mus musculus

Protein protein Q21981069

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Hypoxia inducible factor 1, alpha subunit

Summary

Hypoxia inducible factor 1, alpha subunit is a protein^[1].

Key Facts

Hypoxia inducible factor 1, alpha subunit's instance of is recorded as protein^[2].
Hypoxia inducible factor 1, alpha subunit's subclass of is recorded as protein^[3].
Hypoxia inducible factor 1, alpha subunit's UniProt protein ID is recorded as Amalie Auguste of Bavaria^[4].
Hypoxia inducible factor 1, alpha subunit's part of is recorded as hypoxia-inducible factor-1 alpha^[5].
Hypoxia inducible factor 1, alpha subunit's part of is recorded as PAS domain superfamily^[6].
Hypoxia inducible factor 1, alpha subunit's part of is recorded as Helix-loop-helix DNA-binding domain superfamily^[7].
Hypoxia inducible factor 1, alpha subunit's part of is recorded as Myc-type, basic helix-loop-helix (bHLH) domain, protein family^[8].
Hypoxia inducible factor 1, alpha subunit's part of is recorded as HIF-1 alpha, transactivation domain, C-terminal domain, protein family^[9].
Hypoxia inducible factor 1, alpha subunit's part of is recorded as PAS fold family^[10].
Hypoxia inducible factor 1, alpha subunit's part of is recorded as PAS fold-3 domain, protein family^[11].
Hypoxia inducible factor 1, alpha subunit's part of is recorded as PAC motif domain, protein family^[12].
Hypoxia inducible factor 1, alpha subunit's part of is recorded as PAS domain, protein family^[13].
Hypoxia inducible factor 1, alpha subunit's has part is recorded as Myc-type, basic helix-loop-helix (bHLH) domain^[14].
Hypoxia inducible factor 1, alpha subunit's has part is recorded as PAS fold-3^[15].
Hypoxia inducible factor 1, alpha subunit's has part is recorded as HIF-1 alpha, transactivation domain, C-terminal^[16].
Hypoxia inducible factor 1, alpha subunit's has part is recorded as PAC motif^[17].
Hypoxia inducible factor 1, alpha subunit's has part is recorded as PAS fold^[18].
Hypoxia inducible factor 1, alpha subunit's has part is recorded as PAS domain^[19].
Hypoxia inducible factor 1, alpha subunit's RefSeq protein ID is recorded as NP_001300848^[20].
Hypoxia inducible factor 1, alpha subunit's RefSeq protein ID is recorded as NP_001300849^[21].
Hypoxia inducible factor 1, alpha subunit's RefSeq protein ID is recorded as NP_034561^[22].
Hypoxia inducible factor 1, alpha subunit's RefSeq protein ID is recorded as XP_006515541^[23].
Hypoxia inducible factor 1, alpha subunit's RefSeq protein ID is recorded as XP_017170450^[24].
Hypoxia inducible factor 1, alpha subunit's RefSeq protein ID is recorded as XP_036013089^[25].
Hypoxia inducible factor 1, alpha subunit's PDB structure ID is recorded as 4ZPR^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of hypoxia-inducible factor-1 alpha, PAS domain superfamily, Helix-loop-helix DNA-binding domain superfamily, Myc-type, basic helix-loop-helix (bHLH) domain, protein family, HIF-1 alpha, transactivation domain, C-terminal domain, protein family, PAS fold family, PAS fold-3 domain, protein family, PAC motif domain, protein family, PAS domain, protein family

Properties

Biological process negative regulation of neuron apoptotic process, B-1 B cell homeostasis, regulation of transforming growth factor beta2 production, muscle cell cellular homeostasis, outflow tract morphogenesis, negative regulation of ossification, heart looping, negative regulation of TOR signaling, blood vessel development, hemoglobin biosynthetic process, angiogenesis, positive regulation of insulin secretion involved in cellular response to glucose stimulus, cellular response to hypoxia, positive regulation of hormone biosynthetic process, negative regulation of mesenchymal cell apoptotic process, regulation of aerobic respiration, positive regulation of neuroblast proliferation, dopaminergic neuron differentiation, lactate metabolic process, regulation of transcription, DNA-templated, blood vessel morphogenesis, positive regulation of erythrocyte differentiation, glucose homeostasis, regulation of thymocyte apoptotic process, vascular endothelial growth factor production, positive regulation of epithelial cell migration, negative regulation of thymocyte apoptotic process, transcription, DNA-templated, positive regulation of transcription, DNA-templated, axonal transport of mitochondrion, positive regulation of macroautophagy, cartilage development, lactation, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, positive regulation of pri-miRNA transcription by RNA polymerase II, digestive tract morphogenesis, cell differentiation, neural fold elevation formation, positive regulation of autophagy, retina vasculature development in camera-type eye, collagen metabolic process, embryonic placenta development, regulation of glycolytic process, cellular response to interleukin-1, epithelial to mesenchymal transition, cerebral cortex development, regulation of gene expression, intestinal epithelial cell maturation, regulation of catalytic activity, positive regulation of autophagy of mitochondrion, cardiac ventricle morphogenesis, response to muscle activity, epithelial cell differentiation involved in mammary gland alveolus development, visual learning, positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of bone mineralization, negative regulation of growth, response to hypoxia, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, iris morphogenesis, hypoxia-inducible factor-1alpha signaling pathway, positive regulation of gene expression, vasculature development, regulation of cell population proliferation, neural crest cell migration, connective tissue replacement involved in inflammatory response wound healing, embryonic hemopoiesis, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, negative regulation of reactive oxygen species metabolic process, positive regulation of vascular endothelial growth factor production, elastin metabolic process, oxygen homeostasis, camera-type eye morphogenesis, signal transduction, positive regulation of transcription by RNA polymerase II, cellular iron ion homeostasis, positive regulation of angiogenesis, transcription by RNA polymerase II, response to iron ion, negative regulation of gene expression, positive regulation of blood vessel endothelial cell migration, negative regulation of transcription by RNA polymerase II, positive regulation of cell population proliferation, positive regulation of apoptotic process, negative regulation of apoptotic process, positive regulation of gluconeogenesis, negative regulation of vasoconstriction, positive regulation of smooth muscle cell proliferation, response to fungicide, regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II

Cell component cytoplasm, cytosol, nucleus, nuclear speck, motile cilium, transcription regulator complex, RNA polymerase II transcription regulator complex, axon cytoplasm, nucleoplasm, nuclear body, protein-containing complex, nucleus

Encoded by Hif1a

Found in taxon house mouse

Has part(s) Myc-type, basic helix-loop-helix (bHLH) domain, PAS fold-3, HIF-1 alpha, transactivation domain, C-terminal, PAC motif, PAS fold, PAS domain

Imported from wholeness_audit_2026-05-02

Molecular function protein dimerization activity, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, histone deacetylase binding, transcription factor binding, enzyme binding, protein binding, histone acetyltransferase binding, protein kinase binding, DNA binding, sequence-specific DNA binding, Hsp90 protein binding, DNA-binding transcription activator activity, RNA polymerase II-specific, protein heterodimerization activity, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, ubiquitin protein ligase binding, E-box binding, p53 binding, protein domain specific binding, DNA-binding transcription factor activity, RNA polymerase II-specific, protein-containing complex binding, protein heterodimerization activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding

External References (4)

Ensembl protein id ENSMUSP00000021530, ENSMUSP00000106088, ENSMUSP00000106091

Pdb structure id 4ZPR

Refseq protein id NP_001300848, NP_001300849, NP_034561, XP_006515541, XP_017170450, XP_036013089

Uniprot protein id Amalie Auguste of Bavaria

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Hypoxia inducible factor 1, alpha subunit — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Hypoxia inducible factor 1, alpha subunit — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Hypoxia inducible factor 1, alpha subunit — UniProt protein ID (P352): Amalie Auguste of Bavaria. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Hypoxia inducible factor 1, alpha subunit — part of (P361): hypoxia-inducible factor-1 alpha. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Hypoxia inducible factor 1, alpha subunit — part of (P361): PAS domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Hypoxia inducible factor 1, alpha subunit — part of (P361): Helix-loop-helix DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Hypoxia inducible factor 1, alpha subunit — part of (P361): Myc-type, basic helix-loop-helix (bHLH) domain, protein family. wikidata.org.
[9] ↑ Hypoxia inducible factor 1, alpha subunit — part of (P361): HIF-1 alpha, transactivation domain, C-terminal domain, protein family. wikidata.org.
[10] ↑ Hypoxia inducible factor 1, alpha subunit — part of (P361): PAS fold family. wikidata.org.
[11] ↑ Hypoxia inducible factor 1, alpha subunit — part of (P361): PAS fold-3 domain, protein family. wikidata.org.
[12] ↑ Hypoxia inducible factor 1, alpha subunit — part of (P361): PAC motif domain, protein family. wikidata.org.
[13] ↑ Hypoxia inducible factor 1, alpha subunit — part of (P361): PAS domain, protein family. wikidata.org.
[14] ↑ Hypoxia inducible factor 1, alpha subunit — has part(s) (P527): Myc-type, basic helix-loop-helix (bHLH) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Hypoxia inducible factor 1, alpha subunit — has part(s) (P527): PAS fold-3. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Hypoxia inducible factor 1, alpha subunit — has part(s) (P527): HIF-1 alpha, transactivation domain, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Hypoxia inducible factor 1, alpha subunit — has part(s) (P527): PAC motif. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Hypoxia inducible factor 1, alpha subunit — has part(s) (P527): PAS fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Hypoxia inducible factor 1, alpha subunit — has part(s) (P527): PAS domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Hypoxia inducible factor 1, alpha subunit — RefSeq protein ID (P637): NP_001300848. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Hypoxia inducible factor 1, alpha subunit — RefSeq protein ID (P637): NP_001300849. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ Hypoxia inducible factor 1, alpha subunit — RefSeq protein ID (P637): NP_034561. Q20641742. Retrieved 2022-03-20. wikidata.org.
[23] ↑ Hypoxia inducible factor 1, alpha subunit — RefSeq protein ID (P637): XP_006515541. Q20641742. Retrieved 2022-03-20. wikidata.org.
[24] ↑ Hypoxia inducible factor 1, alpha subunit — RefSeq protein ID (P637): XP_017170450. Q20641742. Retrieved 2022-03-20. wikidata.org.
[25] ↑ Hypoxia inducible factor 1, alpha subunit — RefSeq protein ID (P637): XP_036013089. Q20641742. Retrieved 2022-03-20. wikidata.org.
[26] ↑ Hypoxia inducible factor 1, alpha subunit — PDB structure ID (P638): 4ZPR. Q905695. Retrieved 2016-08-09. wikidata.org.

Class ancestry

[1] ↑ Hypoxia inducible factor 1, alpha subunit is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“Hypoxia inducible factor 1, alpha subunit.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/hypoxia-inducible-factor-1-alpha-subunit.

BibTeX

@misc{4ortxyz_hypoxia-inducible-factor-1-alpha-subunit_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Hypoxia inducible factor 1, alpha subunit}}, year = {2026}, url = {https://4ort.xyz/entity/hypoxia-inducible-factor-1-alpha-subunit}, note = {Accessed: 2026-05-03}}

LLM prompt

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