hydroxysteroid 17-beta dehydrogenase 4

mammalian protein found in Homo sapiens
Protein protein Q21117486
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Summary

hydroxysteroid 17-beta dehydrogenase 4 is a protein[1]. It is known by 20 alternative names across languages and contexts.[2]

Key Facts

  • Molecular function: protein homodimerization activity[3], isomerase activity[4], lyase activity[5], 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity[6], oxidoreductase activity[7], long-chain-enoyl-CoA hydratase activity[8], signaling receptor binding[9], 17-beta-hydroxysteroid dehydrogenase (NAD+) activity[10], 3-hydroxyacyl-CoA dehydrogenase activity[11]
  • Cell component: membrane[12], peroxisome[13], peroxisomal membrane[14], peroxisomal matrix[15], mitochondrion[16], cytosol[17]
  • Biological process: estrogen metabolic process[18], androgen metabolic process[19], lipid metabolism[20], alpha-linolenic acid metabolic process[21], very long-chain fatty acid metabolic process[22], Sertoli cell development[23], fatty acid metabolic process[24], very long-chain fatty-acyl-CoA metabolic process[25], fatty acid beta-oxidation using acyl-CoA oxidase[26], osteoblast differentiation[27], medium-chain fatty-acyl-CoA metabolic process[28], fatty acid beta-oxidation[29], bile acid biosynthetic process[30], protein targeting to peroxisome[31]
  • Encoded by: HSD17B4[32]
  • Found in taxon: Homo sapiens[33]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  5. [7] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [9] ↑ . A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [10] ↑ . Molecular cloning of a novel widely expressed human 80 kDa 17 beta-hydroxysteroid dehydrogenase IV. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . Peroxisomal d -hydroxyacyl-CoA dehydrogenase deficiency: Resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . PEX14 is required for microtubule-based peroxisome motility in human cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . Molecular cloning of a novel widely expressed human 80 kDa 17 beta-hydroxysteroid dehydrogenase IV. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . Molecular cloning of a novel widely expressed human 80 kDa 17 beta-hydroxysteroid dehydrogenase IV. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . Peroxisomal d -hydroxyacyl-CoA dehydrogenase deficiency: Resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [32] ↑ . UniProt. Retrieved . wikidata.org.
  31. [33] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). hydroxysteroid 17-beta dehydrogenase 4. Retrieved May 3, 2026, from https://4ort.xyz/entity/hydroxysteroid-17-beta-dehydrogenase-4-q21117486
MLA “hydroxysteroid 17-beta dehydrogenase 4.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/hydroxysteroid-17-beta-dehydrogenase-4-q21117486.
BibTeX @misc{4ortxyz_hydroxysteroid-17-beta-dehydrogenase-4-q21117486_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{hydroxysteroid 17-beta dehydrogenase 4}}, year = {2026}, url = {https://4ort.xyz/entity/hydroxysteroid-17-beta-dehydrogenase-4-q21117486}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): hydroxysteroid 17-beta dehydrogenase 4 — https://4ort.xyz/entity/hydroxysteroid-17-beta-dehydrogenase-4-q21117486 (retrieved 2026-05-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → HSD17B4
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → protein homodimerization activity, isomerase activity, lyase activity +10
    + 12 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 4.2.1.107, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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