HRas proto-oncogene, GTPase

mammalian protein found in Homo sapiens

Protein protein Q5635781

Press Enter · cited answer in seconds

HRas proto-oncogene, GTPase

Summary

HRas proto-oncogene, GTPase is a protein^[1].

Key Facts

HRas proto-oncogene, GTPase's instance of is recorded as protein^[2].
HRas proto-oncogene, GTPase's physically interacts with is recorded as lonafarnib^[3].
HRas proto-oncogene, GTPase's physically interacts with is recorded as salirasib^[4].
Jennifer Harvey is named after HRas proto-oncogene, GTPase^[5].
HRas proto-oncogene, GTPase is part of small GTPase superfamily, ras-type^[6].
HRas proto-oncogene, GTPase is part of P-loop containing nucleoside triphosphate hydrolase^[7].
HRas proto-oncogene, GTPase is part of Small GTP-binding protein domain family^[8].
HRas proto-oncogene, GTPase comprises small GTP-binding protein domain^[9].

⭐ Popularity Graph

0/100 long tail

Quick Facts

Instance of protein

Part of small GTPase superfamily, ras-type, P-loop containing nucleoside triphosphate hydrolase, Small GTP-binding protein domain family

Properties

Biological process negative regulation of neuron apoptotic process, defense response to protozoan, positive regulation of protein phosphorylation, regulation of long-term neuronal synaptic plasticity, endocytosis, positive regulation of MAP kinase activity, positive regulation of miRNA metabolic process, positive regulation of epithelial cell proliferation, positive regulation of ruffle assembly, mitotic cell cycle checkpoint signaling, positive regulation of cell migration, ephrin receptor signaling pathway, positive regulation of wound healing, positive regulation of Ras protein signal transduction, positive regulation of interferon-gamma production, stimulatory C-type lectin receptor signaling pathway, positive regulation of JNK cascade, negative regulation of gene expression, MAPK cascade, intrinsic apoptotic signaling pathway, positive regulation of GTPase activity, chemotaxis, cell surface receptor signaling pathway, positive regulation of gene expression, negative regulation of GTPase activity, positive regulation of cell population proliferation, positive regulation of ERK1 and ERK2 cascade, animal organ morphogenesis, T-helper 1 type immune response, Ras protein signal transduction, cell population proliferation, T cell receptor signaling pathway, positive regulation of actin cytoskeleton reorganization, positive regulation of MAPK cascade, negative regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, signal transduction, apoptotic process, small GTPase mediated signal transduction, cellular senescence, response to isolation stress, cellular response to gamma radiation, positive regulation of DNA replication, positive regulation of phospholipase C activity, protein heterooligomerization, positive regulation of protein targeting to membrane, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

Cell component cytoplasm, cytosol, Golgi apparatus, intracellular membrane-bounded organelle, membrane, Golgi membrane, plasma membrane, perinuclear region of cytoplasm, nucleus, glutamatergic synapse

Ec enzyme number 3.6.5.2

Encoded by HRAS

Found in taxon Homo sapiens

Has part(s) small GTP-binding protein domain

Molecular function nucleotide binding, protein C-terminus binding, protein binding, GTPase activity, GTP binding, GDP binding

Named after Jennifer Harvey

Physically interacts with lonafarnib, salirasib

External References (4)

Ensembl protein id ENSP00000309845, ENSP00000380722, ENSP00000380723, ENSP00000388246, ENSP00000407586, ENSP00000434023, ENSP00000480317, ENSP00000480686, ENSP00000482366, ENSP00000488225, ENSP00000488296, ENSP00000488757, ENSP00000488397

Pdb structure id 121P, 1AA9, 1AGP, 1BKD, 1CLU, 1CRP, 1CRQ, 1CRR, 1CTQ, 1GNP, 1GNQ, 1GNR, 1HE8, 1IAQ, 1IOZ, 1JAH, 1JAI, 1K8R, 1LF0, 1LF5, 1LFD, 1NVU, 1NVV, 1NVW, 1NVX, 1P2S, 1P2T, 1P2U, 1P2V, 1PLJ, 1PLK, 1PLL, 1Q21, 1QRA, 1RVD, 1WQ1, 1XCM, 1XD2, 1XJ0, 1ZVQ, 1ZW6, 221P, 2C5L, 2CE2, 2CL0, 2CL6, 2CL7, 2CLC, 2CLD, 2EVW, 2LCF, 2LWI, 2Q21, 2QUZ, 2RGA, 2RGB, 2RGC, 2RGD, 2RGE, 2RGG, 2UZI, 2VH5, 2X1V, 3DDC, 3I3S, 3K8Y, 3K9L, 3K9N, 3KKM, 3KKN, 3KUD, 3L8Y, 3L8Z, 3LBH, 3LBI, 3LBN, 3LO5, 3OIU, 3OIV, 3OIW, 3RRY, 3RRZ, 3RS0, 3RS2, 3RS3, 3RS4, 3RS5, 3RS7, 3RSL, 3RSO, 421P, 4DLR, 4DLS, 4DLT, 4DLU, 4DLV, 4DLW, 4DLX, 4DLY, 4DLZ, 4EFL, 4EFM, 4EFN, 4G0N, 4G3X, 4K81, 4Q21, 521P, 5P21, 621P, 6Q21, 721P, 821P, 4L9S, 4L9W, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2N42, 2N46, 4XVQ, 4XVR, 4RSG, 5B30

Refseq protein id NP_001123914, NP_001304983, NP_005334, NP_789765

Uniprot protein id P01112

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ HRas proto-oncogene, GTPase — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ HRas proto-oncogene, GTPase — physically interacts with (P129): lonafarnib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ HRas proto-oncogene, GTPase — physically interacts with (P129): salirasib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[5] ↑ HRas proto-oncogene, GTPase — named after (P138): Jennifer Harvey. wikidata.org.
[6] ↑ HRas proto-oncogene, GTPase — part of (P361): small GTPase superfamily, ras-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ HRas proto-oncogene, GTPase — part of (P361): P-loop containing nucleoside triphosphate hydrolase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ HRas proto-oncogene, GTPase — part of (P361): Small GTP-binding protein domain family. wikidata.org.
[9] ↑ HRas proto-oncogene, GTPase — has part(s) (P527): small GTP-binding protein domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ HRas proto-oncogene, GTPase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). HRas proto-oncogene, GTPase. Retrieved May 3, 2026, from https://4ort.xyz/entity/hras-proto-oncogene-gtpase

MLA

“HRas proto-oncogene, GTPase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/hras-proto-oncogene-gtpase.

BibTeX

@misc{4ortxyz_hras-proto-oncogene-gtpase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{HRas proto-oncogene, GTPase}}, year = {2026}, url = {https://4ort.xyz/entity/hras-proto-oncogene-gtpase}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): HRas proto-oncogene, GTPase — https://4ort.xyz/entity/hras-proto-oncogene-gtpase (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/hras-proto-oncogene-gtpase · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

4w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → P01112

Imported from → —

Ensembl protein id → ENSP00000309845, ENSP00000380722, ENSP00000380723 +10

Encoded by → HRAS

+ 14 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 3.6.5.2, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"

Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.