Histone deacetylase 4

mammalian protein found in Mus musculus

Protein protein Q21984935

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Histone deacetylase 4

Summary

Histone deacetylase 4 is a protein^[1].

Key Facts

Histone deacetylase 4's instance of is recorded as protein^[2].
Histone deacetylase 4's subclass of is recorded as protein^[3].
Histone deacetylase 4's UniProt protein ID is recorded as Q6NZM9^[4].
Histone deacetylase 4's part of is recorded as Histone deacetylase domain superfamily^[5].
Histone deacetylase 4's part of is recorded as Ureohydrolase domain superfamily^[6].
Histone deacetylase 4's part of is recorded as Histone deacetylase 4^[7].
Histone deacetylase 4's part of is recorded as Histone deacetylase, glutamine rich N-terminal domain, protein family^[8].
Histone deacetylase 4's part of is recorded as histone deacetylases^[9].
Histone deacetylase 4's has part is recorded as Histone deacetylase, glutamine rich N-terminal domain^[10].
Histone deacetylase 4's has part is recorded as Histone deacetylase domain^[11].
Histone deacetylase 4's RefSeq protein ID is recorded as NP_997108^[12].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_006529374^[13].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_006529375^[14].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_006529376^[15].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_006529377^[16].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_006529378^[17].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_017174965^[18].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_017174966^[19].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_017174967^[20].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_017174968^[21].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_017174969^[22].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_017174971^[23].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_017174975^[24].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_017174976^[25].
Histone deacetylase 4's RefSeq protein ID is recorded as XP_017174977^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Subclass of protein

Part of Histone deacetylase domain superfamily, Ureohydrolase domain superfamily, Histone deacetylase 4, Histone deacetylase, glutamine rich N-terminal domain, protein family, histone deacetylases

Properties

Biological process histone H3 deacetylation, skeletal system development, chromatin remodeling, peptidyl-lysine deacetylation, regulation of cardiac muscle contraction by calcium ion signaling, negative regulation of glycolytic process, response to interleukin-1, regulation of transcription, DNA-templated, regulation of gene expression, epigenetic, cellular response to tumor necrosis factor, positive regulation of DNA-binding transcription factor activity, negative regulation of transcription by RNA polymerase II, positive regulation of protein sumoylation, negative regulation of DNA-binding transcription factor activity, negative regulation of osteoblast differentiation, transcription, DNA-templated, regulation of striated muscle cell differentiation, positive regulation of transcription, DNA-templated, histone H4 deacetylation, cellular response to mechanical stimulus, positive regulation of cell population proliferation, negative regulation of myotube differentiation, response to denervation involved in regulation of muscle adaptation, osteoblast development, regulation of skeletal muscle fiber development, cellular response to parathyroid hormone stimulus, regulation of protein binding, negative regulation of transcription, DNA-templated, histone deacetylation, positive regulation of transcription by RNA polymerase II, negative regulation of cell population proliferation, chromatin organization, negative regulation of pri-miRNA transcription by RNA polymerase II, protein deacetylation, positive regulation of lamellipodium assembly, positive regulation of smooth muscle cell migration, positive regulation of neuron apoptotic process, positive regulation of smooth muscle cell proliferation, positive regulation of reactive oxygen species biosynthetic process, protein sumoylation, positive regulation of male mating behavior

Cell component cytoplasm, histone deacetylase complex, neuromuscular junction, sarcomere, transcription repressor complex, Z discdkac, A band, actomyosin, nucleus, cytosol, nucleoplasm, protein-containing complex

Encoded by Hdac4

Found in taxon house mouse

Has part(s) Histone deacetylase, glutamine rich N-terminal domain, Histone deacetylase domain

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, NAD-dependent histone deacetylase activity (H3-K14 specific), sequence-specific DNA binding, transcription corepressor activity, histone deacetylase activity, protein deacetylase activity, zinc ion binding, transcription factor binding, histone deacetylase binding, chromatin binding, potassium ion binding, metal ion binding, protein binding, hydrolase activity, protein kinase binding, identical protein binding, promoter-specific chromatin binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SUMO transferase activity

External References (3)

Ensembl protein id ENSMUSP00000008995, ENSMUSP00000095249, ENSMUSP00000140092, ENSMUSP00000141018

Refseq protein id NP_997108, XP_006529374, XP_006529375, XP_006529376, XP_006529377, XP_006529378, XP_017174965, XP_017174966, XP_017174967, XP_017174968, XP_017174969, XP_017174971, XP_017174975, XP_017174976, XP_017174977, XP_017174987, XP_017174990, XP_030108389, XP_030108391, XP_030108401, XP_030108409, XP_030108410, XP_030108412, XP_036019018, XP_036019024

Uniprot protein id Q6NZM9

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Histone deacetylase 4 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Histone deacetylase 4 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Histone deacetylase 4 — UniProt protein ID (P352): Q6NZM9. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Histone deacetylase 4 — part of (P361): Histone deacetylase domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Histone deacetylase 4 — part of (P361): Ureohydrolase domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Histone deacetylase 4 — part of (P361): Histone deacetylase 4. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Histone deacetylase 4 — part of (P361): Histone deacetylase, glutamine rich N-terminal domain, protein family. wikidata.org.
[9] ↑ Histone deacetylase 4 — part of (P361): histone deacetylases. wikidata.org.
[10] ↑ Histone deacetylase 4 — has part(s) (P527): Histone deacetylase, glutamine rich N-terminal domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Histone deacetylase 4 — has part(s) (P527): Histone deacetylase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): NP_997108. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_006529374. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_006529375. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_006529376. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_006529377. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_006529378. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_017174965. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_017174966. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_017174967. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_017174968. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_017174969. Q20641742. Retrieved 2022-03-20. wikidata.org.
[23] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_017174971. Q20641742. Retrieved 2022-03-20. wikidata.org.
[24] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_017174975. Q20641742. Retrieved 2022-03-20. wikidata.org.
[25] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_017174976. Q20641742. Retrieved 2022-03-20. wikidata.org.
[26] ↑ Histone deacetylase 4 — RefSeq protein ID (P637): XP_017174977. Q20641742. Retrieved 2022-03-20. wikidata.org.

Class ancestry

[1] ↑ Histone deacetylase 4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Histone deacetylase 4. Retrieved May 3, 2026, from https://4ort.xyz/entity/histone-deacetylase-4-q21984935

MLA

“Histone deacetylase 4.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/histone-deacetylase-4-q21984935.

BibTeX

@misc{4ortxyz_histone-deacetylase-4-q21984935_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Histone deacetylase 4}}, year = {2026}, url = {https://4ort.xyz/entity/histone-deacetylase-4-q21984935}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Histone deacetylase 4 — https://4ort.xyz/entity/histone-deacetylase-4-q21984935 (retrieved 2026-05-03)

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