Histidyl-tRNA synthetase 2, mitochondrial

mammalian protein found in Homo sapiens
Protein protein Q21105316
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Summary

Histidyl-tRNA synthetase 2, mitochondrial is a protein[1]. It is known by 14 alternative names across languages and contexts.[2]

Key Facts

  • Part of: Anticodon-binding domain superfamily[3], histidine-tRNA ligase[4], Histidyl-anticodon-binding domain, protein family[5], Aminoacyl tRNA synthetases, class II[6]
  • Has part(s): Anticodon-binding[7], Aminoacyl-tRNA synthetase, class II domain[8], Histidyl-anticodon-binding[9]
  • Molecular function: aminoacyl-tRNA ligase activity[10], nucleotide binding[11], ligase activity[12], protein binding[13], ATP binding[14], protein homodimerization activity[15], histidine-tRNA ligase activity[16], RNA binding[17], identical protein binding[18]
  • Cell component: cytoplasm[19], mitochondrial matrix[20], mitochondrion[21], cytosol[22]
  • Biological process: protein biosynthesis[23], histidyl-tRNA aminoacylation[24], mitochondrial translation[25], tRNA aminoacylation for protein translation[26]
  • Encoded by: HARS2[27]
  • Found in taxon: Homo sapiens[28]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . wikidata.org.
  4. [6] ↑ . wikidata.org.
  5. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [8] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [9] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . A proteome-scale map of the human interactome network. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . UniProt. Retrieved . wikidata.org.
  26. [28] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Histidyl-tRNA synthetase 2, mitochondrial. Retrieved May 3, 2026, from https://4ort.xyz/entity/histidyl-trna-synthetase-2-mitochondrial
MLA “Histidyl-tRNA synthetase 2, mitochondrial.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/histidyl-trna-synthetase-2-mitochondrial.
BibTeX @misc{4ortxyz_histidyl-trna-synthetase-2-mitochondrial_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Histidyl-tRNA synthetase 2, mitochondrial}}, year = {2026}, url = {https://4ort.xyz/entity/histidyl-trna-synthetase-2-mitochondrial}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Histidyl-tRNA synthetase 2, mitochondrial — https://4ort.xyz/entity/histidyl-trna-synthetase-2-mitochondrial (retrieved 2026-05-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → HARS2
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → aminoacyl-tRNA ligase activity, nucleotide binding, ligase activity +9
    + 10 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 6.1.1.21, [[:toollabs:quickstatements/#/batch/261489|batch #261489]]"
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