High mobility group box 1
mammalian protein found in Homo sapiens
Facts
9 properties- Instance of
- protein
- Part of
- High mobility group box domain superfamily, High mobility group box domain, protein family, HMG box A DNA-binding domain, conserved site, protein family[2][3][4]
- Biological process
- T-helper 1 cell activation, apoptotic DNA fragmentation, adaptive immune response, regulation of transcription by RNA polymerase II, positive regulation of DNA ligation, positive regulation of JNK cascade, cellular response to DNA damage stimulus, apoptotic cell clearance, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of toll-like receptor 9 signaling pathway, negative regulation of RNA polymerase II transcription preinitiation complex assembly, positive regulation of dendritic cell differentiation, positive regulation of DNA binding, neuron projection development, negative regulation of blood vessel endothelial cell migration, positive regulation of interleukin-12 production, positive regulation of monocyte chemotaxis, activation of innate immune response, DNA ligation involved in DNA repair, innate immune response, inflammatory response, DNA repair, positive regulation of MAPK cascade, positive regulation of activated T cell proliferation, DNA geometric change, DNA recombination, inflammatory response to antigenic stimulus, positive regulation of interleukin-10 production, immune system process, negative regulation of transcription by RNA polymerase II, regulation of restriction endodeoxyribonuclease activity, chemotaxis, positive regulation of mismatch repair, negative regulation of CD4-positive, alpha-beta T cell differentiation, positive regulation of cytosolic calcium ion concentration, T-helper 1 cell differentiation, dendritic cell chemotaxis, autophagy, neutrophil clearance, V(D)J recombination, positive regulation of apoptotic process, DNA topological change, positive chemotaxis, toll-like receptor signaling pathway, neutrophil degranulation, eye development, myeloid dendritic cell activation, positive regulation of protein phosphorylation, endothelial cell proliferation, plasmacytoid dendritic cell activation, macrophage activation involved in immune response, regulation of tolerance induction, regulation of T cell mediated immune response to tumor cell, base-excision repair, regulation of autophagy, lung development, activation of protein kinase activity, positive regulation of interferon-alpha production, positive regulation of interferon-beta production, positive regulation of interleukin-6 production, positive regulation of tumor necrosis factor production, positive regulation of toll-like receptor 2 signaling pathway, positive regulation of toll-like receptor 4 signaling pathway, endothelial cell chemotaxis, positive regulation of innate immune response, positive regulation of myeloid cell differentiation, positive regulation of glycogen catabolic process, regulation of protein kinase activity, positive regulation of transcription by RNA polymerase II, response to glucocorticoid, positive regulation of ERK1 and ERK2 cascade, positive regulation of wound healing, positive regulation of NIK/NF-kappaB signaling, positive regulation of sprouting angiogenesis, negative regulation of apoptotic cell clearance, regulation of nucleotide-excision repair, regulation of signaling receptor activity, negative regulation of transcription by RNA polymerase II, myeloid dendritic cell activation, activation of innate immune response, regulation of tolerance induction, regulation of T cell mediated immune response to tumor cell, DNA recombination, chromatin remodeling, regulation of transcription by RNA polymerase II, regulation of signaling receptor activity, regulation of autophagy, positive regulation of autophagy, developmental process, positive regulation of interleukin-6 production, positive regulation of tumor necrosis factor production, positive regulation of blood vessel endothelial cell migration, positive regulation of innate immune response, positive regulation of transcription by RNA polymerase II, cell chemotaxis, positive regulation of ERK1 and ERK2 cascade, cellular response to lipopolysaccharide, positive regulation of NIK/NF-kappaB signaling, positive regulation of vascular endothelial cell proliferation, negative regulation of apoptotic cell clearance, negative regulation of interferon-gamma production
- Cell component
- cytoplasm, endosome, membrane, transcription repressor complex, extracellular region, nucleus, cell surface, plasma membrane, nucleoplasm, chromosome, condensed chromosome, endoplasmic reticulum-Golgi intermediate compartment, secretory granule lumen, ficolin-1-rich granule lumen, extracellular space, early endosome, neuron projection, extracellular space, nucleus, cytoplasm, alphav-beta3 integrin-HMGB1 complex
- Encoded by
- HMGB1
- Found in taxon
- Homo sapiens
- Has parts
- HMG box A DNA-binding domain, conserved site, High mobility group box domain
- Molecular function
- DNA-binding transcription factor activity, bubble DNA binding, DNA polymerase binding, C-X-C chemokine binding, transcription factor binding, phosphatidylserine binding, lipopolysaccharide binding, lyase activity, single-stranded DNA binding, damaged DNA binding, protein binding, DNA binding, bending, supercoiled DNA binding, DNA binding, four-way junction DNA binding, RAGE receptor binding, chemoattractant activity, RNA binding, double-stranded DNA binding, double-stranded RNA binding, single-stranded RNA binding, cytokine activity, calcium-dependent protein kinase regulator activity, protein kinase activator activity, double-stranded DNA binding, transcription coactivator activity, RNA binding, cytokine activity, integrin binding, transcription factor binding, DNA binding, bending[7][8]
🏷️ Also known as
en Sulfoglucuronyl carbohydrate binding protein
en Amphoterin
en High mobility group box 1
en high-mobility group (nonhistone chromosomal) protein 1
en High mobility group protein 1
en high mobility group protein B1
en HMG-1
en HMGB1
en HMGB1 Protein
de High-Mobility-Group-Protein B1
ja 高移動度群蛋白質B1
🔖 Identifiers · 10
- OpenAlex ID
- C2780545709
- Ensembl protein ID
- ENSP00000343040, ENSP00000345347, ENSP00000382417, ENSP00000384678, ENSP00000369904, ENSP00000382412
- Freebase ID
- /m/03csctt
- MeSH descriptor ID
- D024243
- Microsoft Academic ID (discontinued)
- 2780545709
- RefSeq protein ID
- NP_001300821, NP_001300822, NP_002119, XP_024305109, NP_001350590, NP_001357268, NP_001357269, NP_001357270
- UMLS CUI
- C0019796
- UniProt protein ID
- P09429
🔗 Connections
Cell component 10
Biological process 6
Found in taxon 1
Instance of 1
Molecular function 1
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Summary
High mobility group box 1 is a protein[1].