Hexokinase 2

mammalian protein found in Homo sapiens
Protein Q21118406

Facts

9 properties
Instance of
protein
Part of
Hexokinase, subgroup, Hexokinase, C-terminal domain, protein family, Hexokinase, N-terminal domain, protein family, Hexokinase, binding site, protein family[1][2][3][4]
Biological process
phosphorylation, regulation of glucose import, canonical glycolysis, cellular glucose homeostasis, negative regulation of mitochondrial membrane permeability, carbohydrate phosphorylation, response to ischemia, maintenance of protein location in mitochondrion, establishment of protein localization to mitochondrion, apoptotic mitochondrial changes, negative regulation of reactive oxygen species metabolic process, hexose metabolic process, metabolism, lactation, glycolytic process, positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization, glucose metabolic process, glucose 6-phosphate metabolic process, cellular response to leukemia inhibitory factor, carbohydrate metabolic process, response to hypoxia, glycolytic process, positive regulation of angiogenesis[27][28][29][30][31][32][33][34][35][36][37][38][39][40]
EC enzyme number
2.7.1.1[8]
Encoded by
HK2[41]
Found in taxon
Homo sapiens[42]
Has part(s)
Hexokinase, binding site, Hexokinase, N-terminal, Hexokinase, C-terminal[5][6][7]
Molecular function
transferase activity, nucleotide binding, mannokinase activity, hexokinase activity, phosphotransferase activity, alcohol group as acceptor, kinase activity, glucose binding, catalytic activity, protein binding, fructokinase activity, ATP binding, glucokinase activity, glucokinase activity[9][10][11][12][13][14][15][16][17][18][19][20]
🏷️ Also known as
en hexokinase-2 en Hexokinase 2 en hexokinase-2, muscle en hexokinase-B en hexokinase type II en HK2 en HK II en muscle form hexokinase
🔖 Identifiers · 6
Ensembl protein ID
ENSP00000290573, ENSP00000387140
Freebase ID
/m/05f8y4j
Microsoft Academic ID (discontinued)
2909960852
PDB structure ID
2NZT, 5HFU, 5HG1, 5HEX
UniProt protein ID
P52789

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References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [2] ↑ . wikidata.org.
  3. [3] ↑ . wikidata.org.
  4. [4] ↑ . wikidata.org.
  5. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [6] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [8] ↑ . UniProt. Retrieved . wikidata.org.
  9. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [11] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [12] ↑ . Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [17] ↑ . Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [18] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [23] ↑ . Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [32] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [33] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [34] ↑ . Hexokinase activity is required for recruitment of parkin to depolarized mitochondria. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [35] ↑ . Hexokinase activity is required for recruitment of parkin to depolarized mitochondria. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [37] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [38] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [39] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  40. [40] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  41. [41] ↑ . UniProt. Retrieved . wikidata.org.
  42. [42] ↑ . UniProt. Retrieved . wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Hexokinase 2. Retrieved November 10, 2026, from https://4ort.xyz/entity/hexokinase-2
MLA “Hexokinase 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 10 Nov. 2026, https://4ort.xyz/entity/hexokinase-2.
BibTeX @misc{4ortxyz_hexokinase-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Hexokinase 2}}, year = {2026}, url = {https://4ort.xyz/entity/hexokinase-2}, note = {Accessed: 2026-11-10}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 16w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Found in taxon → Homo sapiens
    Encoded by → HK2
    Cell component → cytosol, membrane, mitochondrial outer membrane +1
    Part of → Hexokinase, subgroup, Hexokinase, C-terminal domain, protein family, Hexokinase, N-terminal domain, protein family +1
    + 5 other properties edited (see Wikidata diff for full list)
    "Created claim: EC enzyme number: 2.7.1.1, batch #261491"
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