Hepatocyte nuclear factor 4, alpha

mammalian protein found in Rattus norvegicus

Protein protein Q28563180

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Hepatocyte nuclear factor 4, alpha

Summary

Hepatocyte nuclear factor 4, alpha is a protein^[1].

Key Facts

Hepatocyte nuclear factor 4, alpha's instance of is recorded as protein^[2].
Hepatocyte nuclear factor 4, alpha's subclass of is recorded as protein^[3].
Hepatocyte nuclear factor 4, alpha's UniProt protein ID is recorded as P22449^[4].
Hepatocyte nuclear factor 4, alpha's RefSeq protein ID is recorded as NP_001257860^[5].
Hepatocyte nuclear factor 4, alpha's RefSeq protein ID is recorded as NP_001257862^[6].
Hepatocyte nuclear factor 4, alpha's RefSeq protein ID is recorded as NP_071516^[7].
Hepatocyte nuclear factor 4, alpha's RefSeq protein ID is recorded as XP_006235577^[8].
Hepatocyte nuclear factor 4, alpha's RefSeq protein ID is recorded as XP_006235578^[9].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as fatty-acyl-CoA binding^[10].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as cis-regulatory region sequence-specific DNA binding^[11].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[12].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as DNA binding^[13].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as DNA-binding transcription factor activity^[14].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as steroid hormone receptor activity^[15].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as nuclear receptor activity^[16].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as fatty acid binding^[17].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as protein binding^[18].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as transcription factor binding^[19].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as zinc ion binding^[20].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as palmitoyl-CoA hydrolase activity^[21].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as long-chain fatty acyl-CoA binding^[22].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as protein homodimerization activity^[23].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as sequence-specific DNA binding^[24].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as metal ion binding^[25].
Hepatocyte nuclear factor 4, alpha's molecular function is recorded as arachidonic acid binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Properties

Biological process type B pancreatic cell development, regulation of transcription, DNA-templated, acyl-CoA metabolic process, establishment of tissue polarity, ageing, negative regulation of cell population proliferation, response to glucose, cell differentiation, negative regulation of cell migration, intracellular receptor signaling pathway, response to nutrient levels, response to lipopolysaccharide, regulation of microvillus assembly, negative regulation of tyrosine phosphorylation of STAT protein, steroid hormone mediated signaling pathway, negative regulation of DNA-binding transcription factor activity, cell-cell junction organization, positive regulation of gluconeogenesis, positive regulation of fatty acid biosynthetic process, positive regulation of transcription, DNA-templated, negative regulation of mitotic cell cycle, positive regulation of transcription by RNA polymerase II, regulation of insulin secretion, response to cAMP, lipid homeostasis, hepatocyte differentiation, cellular response to hypoxia, response to dexamethasone, negative regulation of activation of Janus kinase activity, regulation of circadian rhythm, negative regulation of transcription, DNA-templated, rhythmic process

Cell component nucleus, cytoplasm

Encoded by Hnf4a

Found in taxon brown rat

Imported from wholeness_audit_2026-05-02

Molecular function fatty-acyl-CoA binding, cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA binding, DNA-binding transcription factor activity, steroid hormone receptor activity, nuclear receptor activity, fatty acid binding, protein binding, transcription factor binding, zinc ion binding, palmitoyl-CoA hydrolase activity, long-chain fatty acyl-CoA binding, protein homodimerization activity, sequence-specific DNA binding, metal ion binding, arachidonic acid binding, stearic acid binding

External References (3)

Ensembl protein id ENSRNOP00000011978, ENSRNOP00000071432, ENSRNOP00000073501, ENSRNOP00000077807

Refseq protein id NP_001257860, NP_001257862, NP_071516, XP_006235577, XP_006235578

Uniprot protein id P22449

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Hepatocyte nuclear factor 4, alpha — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Hepatocyte nuclear factor 4, alpha — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Hepatocyte nuclear factor 4, alpha — UniProt protein ID (P352): P22449. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Hepatocyte nuclear factor 4, alpha — RefSeq protein ID (P637): NP_001257860. Q20641742. Retrieved 2022-03-20. wikidata.org.
[6] ↑ Hepatocyte nuclear factor 4, alpha — RefSeq protein ID (P637): NP_001257862. Q20641742. Retrieved 2022-03-20. wikidata.org.
[7] ↑ Hepatocyte nuclear factor 4, alpha — RefSeq protein ID (P637): NP_071516. Q20641742. Retrieved 2022-03-20. wikidata.org.
[8] ↑ Hepatocyte nuclear factor 4, alpha — RefSeq protein ID (P637): XP_006235577. Q20641742. Retrieved 2022-03-20. wikidata.org.
[9] ↑ Hepatocyte nuclear factor 4, alpha — RefSeq protein ID (P637): XP_006235578. Q20641742. Retrieved 2022-03-20. wikidata.org.
[10] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): fatty-acyl-CoA binding. Thioesterase activity and acyl-CoA/fatty acid cross-talk of hepatocyte nuclear factor-4{alpha}. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): cis-regulatory region sequence-specific DNA binding. Functional characterization of hepatocyte nuclear factor-4 alpha dimerization interface mutants.. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. Hepatocyte nuclear factor-4α interacts with other hepatocyte nuclear factors in regulating transthyretin gene expression. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): DNA binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): DNA-binding transcription factor activity. Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): steroid hormone receptor activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): nuclear receptor activity. GOA. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): fatty acid binding. Thioesterase activity and acyl-CoA/fatty acid cross-talk of hepatocyte nuclear factor-4{alpha}. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): protein binding. Physical and Functional Interaction of Acyl-CoA-binding Protein with Hepatocyte Nuclear Factor-4α. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): transcription factor binding. Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): zinc ion binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): palmitoyl-CoA hydrolase activity. Thioesterase activity and acyl-CoA/fatty acid cross-talk of hepatocyte nuclear factor-4{alpha}. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): long-chain fatty acyl-CoA binding. Ligand specificity and conformational dependence of the hepatic nuclear factor-4alpha (HNF-4alpha ).. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): protein homodimerization activity. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): sequence-specific DNA binding. Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): metal ion binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Hepatocyte nuclear factor 4, alpha — molecular function (P680): arachidonic acid binding. Ligand specificity and conformational dependence of the hepatic nuclear factor-4alpha (HNF-4alpha ).. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Hepatocyte nuclear factor 4, alpha is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_hepatocyte-nuclear-factor-4-alpha-q28563180_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Hepatocyte nuclear factor 4, alpha}}, year = {2026}, url = {https://4ort.xyz/entity/hepatocyte-nuclear-factor-4-alpha-q28563180}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Hepatocyte nuclear factor 4, alpha — https://4ort.xyz/entity/hepatocyte-nuclear-factor-4-alpha-q28563180 (retrieved 2026-05-03)

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