Hepatocyte nuclear factor 4 alpha

mammalian protein found in Homo sapiens

Protein protein Q21114166

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Hepatocyte nuclear factor 4 alpha

Summary

Hepatocyte nuclear factor 4 alpha is a protein^[1].

Key Facts

Hepatocyte nuclear factor 4 alpha's instance of is recorded as protein^[2].
Hepatocyte nuclear factor 4 alpha's physically interacts with is recorded as linoleic acid^[3].
Hepatocyte nuclear factor 4 alpha's UniProt protein ID is recorded as P41235^[4].
Hepatocyte nuclear factor 4 alpha's RefSeq protein ID is recorded as NP_000448^[5].
Hepatocyte nuclear factor 4 alpha's RefSeq protein ID is recorded as NP_001025174^[6].
Hepatocyte nuclear factor 4 alpha's RefSeq protein ID is recorded as NP_001025175^[7].
Hepatocyte nuclear factor 4 alpha's RefSeq protein ID is recorded as NP_001245284^[8].
Hepatocyte nuclear factor 4 alpha's RefSeq protein ID is recorded as NP_001274111^[9].
Hepatocyte nuclear factor 4 alpha's RefSeq protein ID is recorded as NP_001274112^[10].
Hepatocyte nuclear factor 4 alpha's RefSeq protein ID is recorded as NP_001274113^[11].
Hepatocyte nuclear factor 4 alpha's RefSeq protein ID is recorded as NP_787110^[12].
Hepatocyte nuclear factor 4 alpha's RefSeq protein ID is recorded as NP_849180^[13].
Hepatocyte nuclear factor 4 alpha's RefSeq protein ID is recorded as NP_849181^[14].
Hepatocyte nuclear factor 4 alpha's RefSeq protein ID is recorded as XP_005260464^[15].
Hepatocyte nuclear factor 4 alpha's PDB structure ID is recorded as 1PZL^[16].
Hepatocyte nuclear factor 4 alpha's PDB structure ID is recorded as 3CBB^[17].
Hepatocyte nuclear factor 4 alpha's PDB structure ID is recorded as 3FS1^[18].
Hepatocyte nuclear factor 4 alpha's PDB structure ID is recorded as 4B7W^[19].
Hepatocyte nuclear factor 4 alpha's PDB structure ID is recorded as 4IQR^[20].
Hepatocyte nuclear factor 4 alpha's molecular function is recorded as DNA binding^[21].
Hepatocyte nuclear factor 4 alpha's molecular function is recorded as sequence-specific DNA binding^[22].
Hepatocyte nuclear factor 4 alpha's molecular function is recorded as DNA-binding transcription factor activity^[23].
Hepatocyte nuclear factor 4 alpha's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[24].
Hepatocyte nuclear factor 4 alpha's molecular function is recorded as zinc ion binding^[25].
Hepatocyte nuclear factor 4 alpha's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[26].

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Quick Facts

Instance of protein

Properties

Biological process triglyceride homeostasis, ornithine metabolic process, phospholipid homeostasis, regulation of transcription, DNA-templated, SMAD protein signal transduction, glucose homeostasis, regulation of insulin secretion, lipid metabolism, regulation of transcription by RNA polymerase II, signal transduction involved in regulation of gene expression, sex differentiation, blood coagulation, response to glucose, transcription, DNA-templated, positive regulation of transcription, DNA-templated, regulation of lipid metabolic process, intracellular receptor signaling pathway, regulation of growth hormone receptor signaling pathway, negative regulation of cell growth, lipid homeostasis, xenobiotic metabolic process, transcription initiation from RNA polymerase II promoter, regulation of gastrulation, steroid hormone mediated signaling pathway, positive regulation of transcription by RNA polymerase II, negative regulation of cell population proliferation, cholesterol homeostasis, type B pancreatic cell development, lipid homeostasis, hepatocyte differentiation, regulation of circadian rhythm, negative regulation of transcription, DNA-templated, rhythmic process

Cell component nucleus, cytoplasm, nucleoplasm

Encoded by HNF4A

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, sequence-specific DNA binding, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, zinc ion binding, DNA-binding transcription activator activity, RNA polymerase II-specific, metal ion binding, steroid hormone receptor activity, nuclear receptor activity, protein binding, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, signaling receptor binding, fatty acid binding, protein homodimerization activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific

Physically interacts with linoleic acid

External References (4)

Ensembl protein id ENSP00000312987, ENSP00000315180, ENSP00000396216, ENSP00000410911, ENSP00000412111, ENSP00000476609, ENSP00000362011, ENSP00000476310, ENSP00000481331

Pdb structure id 1PZL, 3CBB, 3FS1, 4B7W, 4IQR

Refseq protein id NP_000448, NP_001025174, NP_001025175, NP_001245284, NP_001274111, NP_001274112, NP_001274113, NP_787110, NP_849180, NP_849181, XP_005260464

Uniprot protein id P41235

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Hepatocyte nuclear factor 4 alpha — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Hepatocyte nuclear factor 4 alpha — physically interacts with (P129): linoleic acid. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ Hepatocyte nuclear factor 4 alpha — UniProt protein ID (P352): P41235. Q905695. Retrieved 2019-11-13. wikidata.org.
[5] ↑ Hepatocyte nuclear factor 4 alpha — RefSeq protein ID (P637): NP_000448. Q20641742. Retrieved 2020-05-30. wikidata.org.
[6] ↑ Hepatocyte nuclear factor 4 alpha — RefSeq protein ID (P637): NP_001025174. Q20641742. Retrieved 2020-05-30. wikidata.org.
[7] ↑ Hepatocyte nuclear factor 4 alpha — RefSeq protein ID (P637): NP_001025175. Q20641742. Retrieved 2020-05-30. wikidata.org.
[8] ↑ Hepatocyte nuclear factor 4 alpha — RefSeq protein ID (P637): NP_001245284. Q20641742. Retrieved 2020-05-30. wikidata.org.
[9] ↑ Hepatocyte nuclear factor 4 alpha — RefSeq protein ID (P637): NP_001274111. Q20641742. Retrieved 2020-05-30. wikidata.org.
[10] ↑ Hepatocyte nuclear factor 4 alpha — RefSeq protein ID (P637): NP_001274112. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ Hepatocyte nuclear factor 4 alpha — RefSeq protein ID (P637): NP_001274113. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ Hepatocyte nuclear factor 4 alpha — RefSeq protein ID (P637): NP_787110. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ Hepatocyte nuclear factor 4 alpha — RefSeq protein ID (P637): NP_849180. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ Hepatocyte nuclear factor 4 alpha — RefSeq protein ID (P637): NP_849181. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ Hepatocyte nuclear factor 4 alpha — RefSeq protein ID (P637): XP_005260464. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ Hepatocyte nuclear factor 4 alpha — PDB structure ID (P638): 1PZL. Q905695. Retrieved 2016-08-09. wikidata.org.
[17] ↑ Hepatocyte nuclear factor 4 alpha — PDB structure ID (P638): 3CBB. Q905695. Retrieved 2016-08-09. wikidata.org.
[18] ↑ Hepatocyte nuclear factor 4 alpha — PDB structure ID (P638): 3FS1. Q905695. Retrieved 2016-08-09. wikidata.org.
[19] ↑ Hepatocyte nuclear factor 4 alpha — PDB structure ID (P638): 4B7W. Q905695. Retrieved 2016-08-09. wikidata.org.
[20] ↑ Hepatocyte nuclear factor 4 alpha — PDB structure ID (P638): 4IQR. Q905695. Retrieved 2016-08-09. wikidata.org.
[21] ↑ Hepatocyte nuclear factor 4 alpha — molecular function (P680): DNA binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Hepatocyte nuclear factor 4 alpha — molecular function (P680): sequence-specific DNA binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Hepatocyte nuclear factor 4 alpha — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Hepatocyte nuclear factor 4 alpha — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Hepatocyte nuclear factor 4 alpha — molecular function (P680): zinc ion binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Hepatocyte nuclear factor 4 alpha — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Hepatocyte nuclear factor 4 alpha is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Hepatocyte nuclear factor 4 alpha. Retrieved May 3, 2026, from https://4ort.xyz/entity/hepatocyte-nuclear-factor-4-alpha

MLA

“Hepatocyte nuclear factor 4 alpha.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/hepatocyte-nuclear-factor-4-alpha.

BibTeX

@misc{4ortxyz_hepatocyte-nuclear-factor-4-alpha_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Hepatocyte nuclear factor 4 alpha}}, year = {2026}, url = {https://4ort.xyz/entity/hepatocyte-nuclear-factor-4-alpha}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Hepatocyte nuclear factor 4 alpha — https://4ort.xyz/entity/hepatocyte-nuclear-factor-4-alpha (retrieved 2026-05-03)

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