Hepatic nuclear factor 4, alpha

mammalian protein found in Mus musculus

Protein protein Q21496454

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Hepatic nuclear factor 4, alpha

Summary

Hepatic nuclear factor 4, alpha is a protein^[1].

Key Facts

Hepatic nuclear factor 4, alpha's instance of is recorded as protein^[2].
Hepatic nuclear factor 4, alpha's subclass of is recorded as protein^[3].
Hepatic nuclear factor 4, alpha's UniProt protein ID is recorded as P49698^[4].
Hepatic nuclear factor 4, alpha's RefSeq protein ID is recorded as NP_001299835^[5].
Hepatic nuclear factor 4, alpha's RefSeq protein ID is recorded as NP_001299836^[6].
Hepatic nuclear factor 4, alpha's RefSeq protein ID is recorded as NP_032287^[7].
Hepatic nuclear factor 4, alpha's RefSeq protein ID is recorded as XP_006498850^[8].
Hepatic nuclear factor 4, alpha's RefSeq protein ID is recorded as XP_006498851^[9].
Hepatic nuclear factor 4, alpha's molecular function is recorded as DNA binding^[10].
Hepatic nuclear factor 4, alpha's molecular function is recorded as protein homodimerization activity^[11].
Hepatic nuclear factor 4, alpha's molecular function is recorded as DNA-binding transcription factor activity^[12].
Hepatic nuclear factor 4, alpha's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[13].
Hepatic nuclear factor 4, alpha's molecular function is recorded as zinc ion binding^[14].
Hepatic nuclear factor 4, alpha's molecular function is recorded as metal ion binding^[15].
Hepatic nuclear factor 4, alpha's molecular function is recorded as steroid hormone receptor activity^[16].
Hepatic nuclear factor 4, alpha's molecular function is recorded as fatty acid binding^[17].
Hepatic nuclear factor 4, alpha's molecular function is recorded as nuclear receptor activity^[18].
Hepatic nuclear factor 4, alpha's molecular function is recorded as protein binding^[19].
Hepatic nuclear factor 4, alpha's molecular function is recorded as transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding^[20].
Hepatic nuclear factor 4, alpha's molecular function is recorded as signaling receptor binding^[21].
Hepatic nuclear factor 4, alpha's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[22].
Hepatic nuclear factor 4, alpha's molecular function is recorded as fatty-acyl-CoA binding^[23].
Hepatic nuclear factor 4, alpha's molecular function is recorded as cis-regulatory region sequence-specific DNA binding^[24].
Hepatic nuclear factor 4, alpha's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[25].
Hepatic nuclear factor 4, alpha's molecular function is recorded as transcription factor binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Properties

Biological process ornithine metabolic process, phospholipid homeostasis, SMAD protein signal transduction, glucose homeostasis, regulation of insulin secretion, lipid metabolism, regulation of transcription by RNA polymerase II, signal transduction involved in regulation of gene expression, sex differentiation, blood coagulation, transcription, DNA-templated, positive regulation of transcription, DNA-templated, regulation of lipid metabolic process, intracellular receptor signaling pathway, negative regulation of cell growth, lipid homeostasis, xenobiotic metabolic process, regulation of gastrulation, triglyceride homeostasis, positive regulation of transcription by RNA polymerase II, negative regulation of cell population proliferation, steroid hormone mediated signaling pathway, endocrine pancreas development, transcription by RNA polymerase II, cholesterol homeostasis, regulation of transcription, DNA-templated, acyl-CoA metabolic process, establishment of tissue polarity, response to glucose, cell differentiation, negative regulation of cell migration, regulation of microvillus assembly, negative regulation of tyrosine phosphorylation of STAT protein, negative regulation of DNA-binding transcription factor activity, cell-cell junction organization, positive regulation of gluconeogenesis, positive regulation of fatty acid biosynthetic process, negative regulation of mitotic cell cycle, negative regulation of activation of Janus kinase activity, type B pancreatic cell development, regulation of insulin secretion, hepatocyte differentiation, regulation of circadian rhythm, negative regulation of transcription, DNA-templated, regulation of circadian rhythm, negative regulation of transcription, DNA-templated, rhythmic process

Cell component cytoplasm, cytosol, nucleus, nucleoplasm, transcription regulator complex

Encoded by Hnf4a

Found in taxon house mouse

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, protein homodimerization activity, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, zinc ion binding, metal ion binding, steroid hormone receptor activity, fatty acid binding, nuclear receptor activity, protein binding, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, signaling receptor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, fatty-acyl-CoA binding, cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription factor binding, palmitoyl-CoA hydrolase activity, long-chain fatty acyl-CoA binding, sequence-specific DNA binding, arachidonic acid binding, stearic acid binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific

External References (3)

Ensembl protein id ENSMUSP00000018094, ENSMUSP00000105038, ENSMUSP00000119479, ENSMUSP00000123511

Refseq protein id NP_001299835, NP_001299836, NP_032287, XP_006498850, XP_006498851

Uniprot protein id P49698

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Hepatic nuclear factor 4, alpha — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Hepatic nuclear factor 4, alpha — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Hepatic nuclear factor 4, alpha — UniProt protein ID (P352): P49698. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Hepatic nuclear factor 4, alpha — RefSeq protein ID (P637): NP_001299835. Q20641742. Retrieved 2022-03-20. wikidata.org.
[6] ↑ Hepatic nuclear factor 4, alpha — RefSeq protein ID (P637): NP_001299836. Q20641742. Retrieved 2022-03-20. wikidata.org.
[7] ↑ Hepatic nuclear factor 4, alpha — RefSeq protein ID (P637): NP_032287. Q20641742. Retrieved 2022-03-20. wikidata.org.
[8] ↑ Hepatic nuclear factor 4, alpha — RefSeq protein ID (P637): XP_006498850. Q20641742. Retrieved 2022-03-20. wikidata.org.
[9] ↑ Hepatic nuclear factor 4, alpha — RefSeq protein ID (P637): XP_006498851. Q20641742. Retrieved 2022-03-20. wikidata.org.
[10] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): DNA binding. Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): protein homodimerization activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): DNA-binding transcription factor activity. Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): zinc ion binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): metal ion binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): steroid hormone receptor activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): fatty acid binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): nuclear receptor activity. GOA. Retrieved 2018-11-07. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): protein binding. Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): signaling receptor binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): fatty-acyl-CoA binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Hepatic nuclear factor 4, alpha — molecular function (P680): transcription factor binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Hepatic nuclear factor 4, alpha is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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BibTeX

@misc{4ortxyz_hepatic-nuclear-factor-4-alpha_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Hepatic nuclear factor 4, alpha}}, year = {2026}, url = {https://4ort.xyz/entity/hepatic-nuclear-factor-4-alpha}, note = {Accessed: 2026-05-03}}

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