Heparanase

mammalian protein found in Homo sapiens
Protein protein Q909646
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Heparanase

Summary

Heparanase is a protein[1]. Heparanase is known by 5 alternative names across languages and contexts.[2]

Key Facts

  • Heparanase's instance of is recorded as protein[3].
  • Heparanase is part of Glycoside hydrolase, family 79[4].
  • Heparanase is part of glycoside hydrolase superfamily[5].
  • Heparanase's molecular function is recorded as protein dimerization activity[6].
  • Heparanase's molecular function is recorded as heparanase activity[7].
  • Heparanase's molecular function is recorded as beta-glucuronidase activity[8].
  • Heparanase's molecular function is recorded as hydrolase activity, acting on glycosyl bonds[9].
  • Heparanase's molecular function is recorded as protein binding[10].
  • Heparanase's molecular function is recorded as syndecan binding[11].
  • Heparanase's molecular function is recorded as hydrolase activity[12].
  • Heparanase's molecular function is recorded as heparanase activity[13].
  • Heparanase's cell component is recorded as intracellular membrane-bounded organelle[14].
  • Heparanase's cell component is recorded as membrane[15].
  • Heparanase's cell component is recorded as nucleoplasm[16].
  • Heparanase's cell component is recorded as lysosomal membrane[17].
  • Heparanase's cell component is recorded as lysosomal lumen[18].
  • Heparanase's cell component is recorded as membrane raft[19].
  • Heparanase's cell component is recorded as lysosome[20].
  • Heparanase's cell component is recorded as nucleus[21].
  • Heparanase's cell component is recorded as extracellular region[22].
  • Heparanase's cell component is recorded as specific granule lumen[23].
  • Heparanase's cell component is recorded as extracellular matrix[24].
  • Heparanase's biological process is recorded as positive regulation of osteoblast proliferation[25].
  • Heparanase's biological process is recorded as positive regulation of protein kinase B signaling[26].
  • Heparanase's biological process is recorded as heparan sulfate proteoglycan catabolic process[27].

Why It Matters

Heparanase is known by 5 alternative names across languages and contexts.[2]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . Q905695. Retrieved . wikidata.org.
  2. [4] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] . Heterodimer formation is essential for heparanase enzymatic activity. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  5. [7] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [8] . Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [9] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [10] . Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] . Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] . Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] . Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Heparanase. Retrieved May 3, 2026, from https://4ort.xyz/entity/heparanase
MLA “Heparanase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/heparanase.
BibTeX @misc{4ortxyz_heparanase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Heparanase}}, year = {2026}, url = {https://4ort.xyz/entity/heparanase}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Heparanase — https://4ort.xyz/entity/heparanase (retrieved 2026-05-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 4w ago · Boghog · 2026-07-23 view diff on Wikidata ↗
    Instance of
    Part of
    Encoded by HPSE
    Biological process positive regulation of osteoblast proliferation, positive regulation of protein kinase B signaling, heparan sulfate proteoglycan catabolic process +13
    + 7 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ [[Property:P591]]: 3.2.1.166, [[:toollabs:quickstatements/#/batch/261446|batch #261446]]"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.