Heat shock factor 1

mammalian protein found in Mus musculus

Protein protein Q21985060

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Heat shock factor 1

Summary

Heat shock factor 1 is a protein^[1].

Key Facts

Heat shock factor 1's instance of is recorded as protein^[2].
Heat shock factor 1's subclass of is recorded as protein^[3].
Heat shock factor 1's UniProt protein ID is recorded as P38532^[4].
Heat shock factor 1's part of is recorded as Heat shock transcription factor family^[5].
Heat shock factor 1's part of is recorded as Winged helix-like DNA-binding domain superfamily^[6].
Heat shock factor 1's part of is recorded as winged helix DNA-binding domain superfamily^[7].
Heat shock factor 1's part of is recorded as Vertebrate heat shock transcription factor, C-terminal domain, protein family^[8].
Heat shock factor 1's part of is recorded as Heat shock factor (HSF)-type, DNA-binding domain, protein family^[9].
Heat shock factor 1's has part is recorded as Heat shock factor (HSF)-type, DNA-binding^[10].
Heat shock factor 1's has part is recorded as Vertebrate heat shock transcription factor, C-terminal domain^[11].
Heat shock factor 1's RefSeq protein ID is recorded as NP_001318081^[12].
Heat shock factor 1's RefSeq protein ID is recorded as NP_001318082^[13].
Heat shock factor 1's RefSeq protein ID is recorded as NP_001318083^[14].
Heat shock factor 1's RefSeq protein ID is recorded as NP_001318143^[15].
Heat shock factor 1's RefSeq protein ID is recorded as NP_032322^[16].
Heat shock factor 1's RefSeq protein ID is recorded as XP_006520537^[17].
Heat shock factor 1's RefSeq protein ID is recorded as XP_006520538^[18].
Heat shock factor 1's RefSeq protein ID is recorded as XP_006520539^[19].
Heat shock factor 1's RefSeq protein ID is recorded as XP_030104202^[20].
Heat shock factor 1's RefSeq protein ID is recorded as XP_036015058^[21].
Heat shock factor 1's RefSeq protein ID is recorded as XP_036015059^[22].
Heat shock factor 1's RefSeq protein ID is recorded as XP_036015060^[23].
Heat shock factor 1's molecular function is recorded as DNA-binding transcription factor activity^[24].
Heat shock factor 1's molecular function is recorded as chromatin binding^[25].
Heat shock factor 1's molecular function is recorded as DNA-binding transcription repressor activity, RNA polymerase II-specific^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Heat shock transcription factor family, Winged helix-like DNA-binding domain superfamily, winged helix DNA-binding domain superfamily, Vertebrate heat shock transcription factor, C-terminal domain, protein family, Heat shock factor (HSF)-type, DNA-binding domain, protein family

Properties

Biological process cellular response to heat, regulation of transcription, DNA-templated, embryonic placenta development, mRNA transcription, in utero embryonic development, female meiotic nuclear division, transcription, DNA-templated, embryonic process involved in female pregnancy, protein phosphorylation, response to lipopolysaccharide, spermatogenesis, positive regulation of multicellular organism growth, negative regulation of tumor necrosis factor production, negative regulation of cell population proliferation, cellular response to nitroglycerin, cellular response to L-glutamine, response to nutrient, cellular response to potassium ion, response to hypobaric hypoxia, response to organonitrogen compound, response to activity, response to psychosocial stress, response to amino acid, response to organic cyclic compound, response to peptide, cellular response to lipopolysaccharide, negative regulation of transcription by RNA polymerase II, DNA repair, mRNA processing, cellular response to DNA damage stimulus, positive regulation of transcription by RNA polymerase II, mRNA transport, protein homooligomerization, positive regulation of transcription from RNA polymerase II promoter in response to heat stress, protein homotrimerization, cellular response to cadmium ion, positive regulation of mRNA polyadenylation, MAPK cascade, positive regulation of cell population proliferation, Unfolded Protein Response, regulation of protein heterodimerization activity, positive regulation of mitotic cell cycle, cellular response to copper ion, cellular response to gamma radiation, cellular response to diamide, regulation of cellular response to heat, cellular response to sodium arsenite, negative regulation of double-strand break repair via nonhomologous end joining, defense response, response to heat, positive regulation of gene expression, negative regulation of gene expression, negative regulation of cardiac muscle cell apoptotic process, response to estradiol, response to testosterone, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, cellular response to hydrogen peroxide, cellular response to amino acid stimulus, cellular response to estradiol stimulus, cellular response to organic cyclic compound, cellular response to radiation, negative regulation of inclusion body assembly, positive regulation of inclusion body assembly, negative regulation of neuron death, positive regulation of apoptotic DNA fragmentation, cellular response to angiotensin, positive regulation of microtubule binding, cellular response to heat, positive regulation of transcription from RNA polymerase II promoter in response to heat stress, positive regulation of cold-induced thermogenesis

Cell component cytoplasm, pronucleus, chromosome, centromeric region, spindle pole, nucleus, nucleoplasm, chromosome, microtubule organizing center, cytoskeleton, PML body, nuclear stress granule, kinetochore, centrosome, cytosol, perinuclear region of cytoplasm, mitotic spindle pole, ribonucleoprotein complex, protein-containing complex, euchromatin, heterochromatin, nucleus

Encoded by Hsf1

Found in taxon house mouse

Has part(s) Heat shock factor (HSF)-type, DNA-binding, Vertebrate heat shock transcription factor, C-terminal domain

Imported from wholeness_audit_2026-05-02

Molecular function DNA-binding transcription factor activity, chromatin binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, DNA binding, protein kinase binding, heat shock protein binding, identical protein binding, protein self-association, chromatin DNA binding, sequence-specific DNA binding, protein heterodimerization activity, Hsp90 protein binding, translation elongation factor binding, promoter-specific chromatin binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, STAT family protein binding, sequence-specific single stranded DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, sequence-specific DNA binding

External References (3)

Ensembl protein id ENSMUSP00000072617, ENSMUSP00000154602, ENSMUSP00000154638, ENSMUSP00000154346, ENSMUSP00000154328, ENSMUSP00000154526, ENSMUSP00000154386, ENSMUSP00000154799, ENSMUSP00000154356, ENSMUSP00000155104

Refseq protein id NP_001318081, NP_001318082, NP_001318083, NP_001318143, NP_032322, XP_006520537, XP_006520538, XP_006520539, XP_030104202, XP_036015058, XP_036015059, XP_036015060

Uniprot protein id P38532

🏷️ Also known as

en Heat shock factor 1 en heat shock factor protein 1 en Heat shock transcription factor 1 en Hsf1 en HSTF 1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Heat shock factor 1 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Heat shock factor 1 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Heat shock factor 1 — UniProt protein ID (P352): P38532. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Heat shock factor 1 — part of (P361): Heat shock transcription factor family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Heat shock factor 1 — part of (P361): Winged helix-like DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Heat shock factor 1 — part of (P361): winged helix DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Heat shock factor 1 — part of (P361): Vertebrate heat shock transcription factor, C-terminal domain, protein family. wikidata.org.
[9] ↑ Heat shock factor 1 — part of (P361): Heat shock factor (HSF)-type, DNA-binding domain, protein family. wikidata.org.
[10] ↑ Heat shock factor 1 — has part(s) (P527): Heat shock factor (HSF)-type, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Heat shock factor 1 — has part(s) (P527): Vertebrate heat shock transcription factor, C-terminal domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Heat shock factor 1 — RefSeq protein ID (P637): NP_001318081. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ Heat shock factor 1 — RefSeq protein ID (P637): NP_001318082. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ Heat shock factor 1 — RefSeq protein ID (P637): NP_001318083. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Heat shock factor 1 — RefSeq protein ID (P637): NP_001318143. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Heat shock factor 1 — RefSeq protein ID (P637): NP_032322. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Heat shock factor 1 — RefSeq protein ID (P637): XP_006520537. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Heat shock factor 1 — RefSeq protein ID (P637): XP_006520538. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Heat shock factor 1 — RefSeq protein ID (P637): XP_006520539. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Heat shock factor 1 — RefSeq protein ID (P637): XP_030104202. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Heat shock factor 1 — RefSeq protein ID (P637): XP_036015058. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ Heat shock factor 1 — RefSeq protein ID (P637): XP_036015059. Q20641742. Retrieved 2022-03-20. wikidata.org.
[23] ↑ Heat shock factor 1 — RefSeq protein ID (P637): XP_036015060. Q20641742. Retrieved 2022-03-20. wikidata.org.
[24] ↑ Heat shock factor 1 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Heat shock factor 1 — molecular function (P680): chromatin binding. Identification of Heat Shock Factor 1 Molecular and Cellular Targets during Embryonic and Adult Female Meiosis. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Heat shock factor 1 — molecular function (P680): DNA-binding transcription repressor activity, RNA polymerase II-specific. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Heat shock factor 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Heat shock factor 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/heat-shock-factor-1

MLA “Heat shock factor 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/heat-shock-factor-1.

BibTeX

@misc{4ortxyz_heat-shock-factor-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Heat shock factor 1}}, year = {2026}, url = {https://4ort.xyz/entity/heat-shock-factor-1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Heat shock factor 1 — https://4ort.xyz/entity/heat-shock-factor-1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/heat-shock-factor-1 · Last refreshed: May 3, 2026