Growth factor receptor bound protein 2

mammalian protein found in Homo sapiens

Protein protein Q5514416

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Summary

Growth factor receptor bound protein 2 is a protein^[1].

Key Facts

Growth factor receptor bound protein 2's instance of is recorded as protein^[2].
Growth factor receptor bound protein 2's UniProt protein ID is recorded as P62993^[3].
Growth factor receptor bound protein 2's part of is recorded as SH3-like domain superfamily^[4].
Growth factor receptor bound protein 2's part of is recorded as Growth factor receptor-bound protein 2^[5].
Growth factor receptor bound protein 2's part of is recorded as SH2 domain superfamily^[6].
Growth factor receptor bound protein 2's part of is recorded as GRB2, N-terminal SH3 domain, protein family^[7].
Growth factor receptor bound protein 2's part of is recorded as GRB2, C-terminal SH3 domain, protein family^[8].
Growth factor receptor bound protein 2's part of is recorded as SH2 domain, protein family^[9].
Growth factor receptor bound protein 2's part of is recorded as SH3 domain, protein family^[10].
Growth factor receptor bound protein 2's MeSH descriptor ID is recorded as D051380^[11].
Growth factor receptor bound protein 2's has part is recorded as SH2 domain^[12].
Growth factor receptor bound protein 2's has part is recorded as SH3 domain^[13].
Growth factor receptor bound protein 2's has part is recorded as GRB2, N-terminal SH3 domain^[14].
Growth factor receptor bound protein 2's has part is recorded as GRB2, C-terminal SH3 domain^[15].
Growth factor receptor bound protein 2's RefSeq protein ID is recorded as NP_002077^[16].
Growth factor receptor bound protein 2's RefSeq protein ID is recorded as NP_987102^[17].
Growth factor receptor bound protein 2's PDB structure ID is recorded as 1AZE^[18].
Growth factor receptor bound protein 2's PDB structure ID is recorded as 1BM2^[19].
Growth factor receptor bound protein 2's PDB structure ID is recorded as 1BMB^[20].
Growth factor receptor bound protein 2's PDB structure ID is recorded as 1CJ1^[21].
Growth factor receptor bound protein 2's PDB structure ID is recorded as 1FHS^[22].
Growth factor receptor bound protein 2's PDB structure ID is recorded as 1FYR^[23].
Growth factor receptor bound protein 2's PDB structure ID is recorded as 1GCQ^[24].
Growth factor receptor bound protein 2's PDB structure ID is recorded as 1GFC^[25].
Growth factor receptor bound protein 2's PDB structure ID is recorded as 1GFD^[26].

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Quick Facts

Instance of protein

Part of SH3-like domain superfamily, Growth factor receptor-bound protein 2, SH2 domain superfamily, GRB2, N-terminal SH3 domain, protein family, GRB2, C-terminal SH3 domain, protein family, SH2 domain, protein family, SH3 domain, protein family

Properties

Biological process T cell costimulation, Fc-gamma receptor signaling pathway involved in phagocytosis, branching involved in labyrinthine layer morphogenesis, MAPK cascade, epidermal growth factor receptor signaling pathway, fibroblast growth factor receptor signaling pathway, insulin receptor signaling pathway, receptor internalization, cell-cell signaling, axon guidance, positive regulation of reactive oxygen species metabolic process, cellular response to ionizing radiation, Fc-epsilon receptor signaling pathway, viral process, positive regulation of actin filament polymerization, signal transduction in response to DNA damage, negative regulation of epidermal growth factor receptor signaling pathway, leukocyte migration, regulation of MAPK cascade, anatomical structure formation involved in morphogenesis, ageing, ERBB2 signaling pathway, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, protein heterooligomerization, entry of bacterium into host cell, membrane organization, cell migration, cell differentiation, peptidyl-tyrosine autophosphorylation, regulation of cell population proliferation, innate immune response, Ras protein signal transduction, interleukin-15-mediated signaling pathway, positive regulation of protein kinase B signaling, regulation of molecular function, cytokine-mediated signaling pathway, cell differentiation, positive regulation of Ras protein signal transduction, neurotrophin TRK receptor signaling pathway

Cell component extracellular exosome, nucleolus, cytoplasm, nucleoplasm, COP9 signalosome, Golgi apparatus, cytosol, nucleus, cell-cell junction, membrane, Grb2-EGFR complex, endosome, vesicle membrane, plasma membrane, extrinsic component of cytoplasmic side of plasma membrane, protein-containing complex, extracellular exosome

Encoded by GRB2

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Has part(s) SH2 domain, SH3 domain, GRB2, N-terminal SH3 domain, GRB2, C-terminal SH3 domain

Imported from wholeness_audit_2026-05-02

Molecular function protein domain specific binding, SH3 domain binding, protein kinase binding, identical protein binding, neurotrophin TRKA receptor binding, protein phosphatase binding, protein binding, ephrin receptor binding, insulin receptor substrate binding, epidermal growth factor receptor binding, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-3-kinase activity, phosphoprotein binding, enzyme binding, RNA binding, non-membrane spanning protein tyrosine kinase activity, phosphotyrosine residue binding, RNA binding

External References (6)

Ensembl protein id ENSP00000317360, ENSP00000339007, ENSP00000376345, ENSP00000376346, ENSP00000376347, ENSP00000462785, ENSP00000463525, ENSP00000464279, ENSP00000496913

Mesh descriptor id D051380

Mesh tree code D12.644.360.024.290, D12.776.157.057.041, D12.776.476.024.377

Pdb structure id 1AZE, 1BM2, 1BMB, 1CJ1, 1FHS, 1FYR, 1GCQ, 1GFC, 1GFD, 1GHU, 1GRI, 1IO6, 1JYQ, 1JYR, 1JYU, 1QG1, 1TZE, 1X0N, 1ZFP, 2AOA, 2AOB, 2H5K, 2HUW, 2VVK, 2VWF, 2W0Z, 3C7I, 3IMD, 3IMJ, 3IN7, 3IN8, 3KFJ, 3MXC, 3MXY, 3N7Y, 3N84, 3N8M, 3OV1, 3OVE, 3S8L, 3S8N, 3S8O, 2H46, 3WA4, 4P9V, 4P9Z, 5CDW

Refseq protein id NP_002077, NP_987102

Uniprot protein id P62993

🏷️ Also known as

en abundant SRC homology en Adapter protein GRB2 en epidermal growth factor receptor-binding protein GRB2 en epididymis secretory sperm binding protein en GRB2 en growth factor receptor-bound protein 2 en Growth factor receptor bound protein 2 en growth factor receptor-bound protein 3 en HT027 en protein Ash en SH2/SH3 adapter GRB2

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Growth factor receptor bound protein 2 — instance of (P31): protein. UniProt. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Growth factor receptor bound protein 2 — UniProt protein ID (P352): P62993. UniProt. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Growth factor receptor bound protein 2 — part of (P361): SH3-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Growth factor receptor bound protein 2 — part of (P361): Growth factor receptor-bound protein 2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Growth factor receptor bound protein 2 — part of (P361): SH2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Growth factor receptor bound protein 2 — part of (P361): GRB2, N-terminal SH3 domain, protein family. wikidata.org.
[8] ↑ Growth factor receptor bound protein 2 — part of (P361): GRB2, C-terminal SH3 domain, protein family. wikidata.org.
[9] ↑ Growth factor receptor bound protein 2 — part of (P361): SH2 domain, protein family. wikidata.org.
[10] ↑ Growth factor receptor bound protein 2 — part of (P361): SH3 domain, protein family. wikidata.org.
[11] ↑ Growth factor receptor bound protein 2 — MeSH descriptor ID (P486): D051380. wikidata.org.
[12] ↑ Growth factor receptor bound protein 2 — has part(s) (P527): SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Growth factor receptor bound protein 2 — has part(s) (P527): SH3 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Growth factor receptor bound protein 2 — has part(s) (P527): GRB2, N-terminal SH3 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Growth factor receptor bound protein 2 — has part(s) (P527): GRB2, C-terminal SH3 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Growth factor receptor bound protein 2 — RefSeq protein ID (P637): NP_002077. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ Growth factor receptor bound protein 2 — RefSeq protein ID (P637): NP_987102. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ Growth factor receptor bound protein 2 — PDB structure ID (P638): 1AZE. UniProt. Retrieved 2016-08-09. wikidata.org.
[19] ↑ Growth factor receptor bound protein 2 — PDB structure ID (P638): 1BM2. UniProt. Retrieved 2016-08-09. wikidata.org.
[20] ↑ Growth factor receptor bound protein 2 — PDB structure ID (P638): 1BMB. UniProt. Retrieved 2016-08-09. wikidata.org.
[21] ↑ Growth factor receptor bound protein 2 — PDB structure ID (P638): 1CJ1. UniProt. Retrieved 2016-08-09. wikidata.org.
[22] ↑ Growth factor receptor bound protein 2 — PDB structure ID (P638): 1FHS. UniProt. Retrieved 2016-08-09. wikidata.org.
[23] ↑ Growth factor receptor bound protein 2 — PDB structure ID (P638): 1FYR. UniProt. Retrieved 2016-08-09. wikidata.org.
[24] ↑ Growth factor receptor bound protein 2 — PDB structure ID (P638): 1GCQ. UniProt. Retrieved 2016-08-09. wikidata.org.
[25] ↑ Growth factor receptor bound protein 2 — PDB structure ID (P638): 1GFC. UniProt. Retrieved 2016-08-09. wikidata.org.
[26] ↑ Growth factor receptor bound protein 2 — PDB structure ID (P638): 1GFD. UniProt. Retrieved 2016-08-09. wikidata.org.

Class ancestry

[1] ↑ Growth factor receptor bound protein 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Growth factor receptor bound protein 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/growth-factor-receptor-bound-protein-2

MLA

“Growth factor receptor bound protein 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/growth-factor-receptor-bound-protein-2.

BibTeX

@misc{4ortxyz_growth-factor-receptor-bound-protein-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Growth factor receptor bound protein 2}}, year = {2026}, url = {https://4ort.xyz/entity/growth-factor-receptor-bound-protein-2}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Growth factor receptor bound protein 2 — https://4ort.xyz/entity/growth-factor-receptor-bound-protein-2 (retrieved 2026-05-03)

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