glycogen synthase kinase 3 beta

mammalian protein found in Homo sapiens

Protein protein Q5514576

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glycogen synthase kinase 3 beta

Summary

glycogen synthase kinase 3 beta is a protein^[1].

Key Facts

glycogen synthase kinase 3 beta's instance of is recorded as protein^[2].
glycogen synthase kinase 3 beta's physically interacts with is recorded as tideglusib^[3].
glycogen synthase kinase 3 beta's physically interacts with is recorded as tideglusib^[4].
glycogen synthase kinase 3 beta's physically interacts with is recorded as lithium citrate^[5].
glycogen synthase kinase 3 beta's physically interacts with is recorded as ly-2090314^[6].
glycogen synthase kinase 3 beta's EC enzyme number is recorded as 2.7.11.1^[7].

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Quick Facts

Instance of protein

Properties

Biological process rhythmic process, negative regulation of type B pancreatic cell development, negative regulation of protein binding, negative regulation of glycogen (starch) synthase activity, glycogen metabolic process, superior temporal gyrus development, negative regulation of canonical Wnt signaling pathway, chemical synaptic transmission, postsynaptic, negative regulation of protein-containing complex assembly, positive regulation of protein export from nucleus, positive regulation of GTPase activity, protein autophosphorylation, cell differentiation, negative regulation of protein localization to nucleus, phosphorylation, positive regulation of cell-matrix adhesion, nervous system development, dopamine receptor signaling pathway, epithelial to mesenchymal transition, peptidyl-threonine phosphorylation, positive regulation of protein-containing complex assembly, positive regulation of neuron death, negative regulation of glycogen biosynthetic process, multicellular organism development, regulation of cellular response to heat, negative regulation of signal transduction, hippocampus development, beta-catenin destruction complex disassembly, proteasome-mediated ubiquitin-dependent protein catabolic process, Wnt signaling pathway, beta-catenin destruction complex assembly, protein phosphorylation, positive regulation of mitochondrion organization, intracellular signal transduction, positive regulation of protein catabolic process, negative regulation of dopaminergic neuron differentiation, ER overload response, circadian rhythm, peptidyl-serine phosphorylation, positive regulation of protein binding, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of microtubule-based process, cellular response to interleukin-3, negative regulation of apoptotic process, canonical Wnt signaling pathway, extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, carbohydrate metabolic process, neuron projection development, negative regulation of neuron death, protein phosphorylation, positive regulation of gene expression, establishment of cell polarity, maintenance of cell polarity, regulation of axon extension, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of phosphoprotein phosphatase activity, regulation of dendrite morphogenesis, regulation of axonogenesis, excitatory postsynaptic potential, regulation of microtubule cytoskeleton organization, negative regulation of calcineurin-NFAT signaling cascade, negative regulation of canonical Wnt signaling pathway, extrinsic apoptotic signaling pathway, neuron projection retraction, negative regulation of protein acetylation, cellular response to amyloid-beta, positive regulation of protein localization to centrosome, regulation of synaptic vesicle exocytosis, neuron projection organization, positive regulation of autophagy, regulation of circadian rhythm, regulation of long-term synaptic potentiation, regulation of microtubule cytoskeleton organization, regulation of microtubule anchoring at centrosome

Cell component cytoplasm, membrane, mitochondrion, nucleus, centrosome, plasma membrane, cytosol, beta-catenin destruction complex, postsynapse, Wnt signalosome, nucleoplasm, axon, dendrite, glutamatergic synapse

Ec enzyme number 2.7.11.1, 2.7.11.26

Encoded by GSK3B

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Molecular function kinase activity, ATP binding, protein kinase activity, protein kinase A catalytic subunit binding, protein serine/threonine kinase activity, transferase activity, NF-kappaB binding, tau-protein kinase activity, protein binding, nucleotide binding, p53 binding, ubiquitin protein ligase binding, protease binding, beta-catenin binding, protein kinase binding, protein kinase activity, protein serine/threonine kinase activity, dynactin binding, tau protein binding, tau-protein kinase activity

Physically interacts with tideglusib, tideglusib, lithium citrate, ly-2090314

External References (8)

Ensembl protein id ENSP00000264235, ENSP00000324806, ENSP00000497956

Mesh descriptor id D000071679

Mesh tree code D05.500.117.875.500, D08.811.913.696.620.682.700.429.500.500, D08.811.913.696.620.682.700.646.625.500, D12.776.476.081.875.500, D12.776.476.563.429.500.500, D12.776.476.563.646.625.500

Microsoft academic id (discontinued) 104629339

Pdb structure id 1GNG, 1H8F, 1I09, 1J1B, 1J1C, 1O6K, 1O6L, 1O9U, 1PYX, 1Q3D, 1Q3W, 1Q41, 1Q4L, 1Q5K, 1R0E, 1UV5, 2JDO, 2JDR, 2JLD, 2O5K, 2OW3, 2UW9, 2X39, 2XH5, 3CQU, 3CQW, 3DU8, 3E87, 3E88, 3E8D, 3F7Z, 3F88, 3GB2, 3I4B, 3L1S, 3M1S, 3MV5, 3OW4, 3PUP, 3Q3B, 3QKK, 3SAY, 3SD0, 3ZDI, 3ZRK, 3ZRL, 3ZRM, 4ACC, 4ACD, 4ACG, 4ACH, 4AFJ, 4B7T, 4DIT, 4EKK, 4IQ6, 4J1R, 4J71, 4NM0, 4NM3, 4NM5, 4NM7, 4PTC, 4PTE, 4PTG, 5F94, 5F95, 5HLP, 5HLN

Refseq protein id NP_001139628, NP_002084, XP_006713673, NP_001341525

Umls cui C0244988

Uniprot protein id P49841

🏷️ Also known as

en 2.7.11.1 en glycogen synthase kinase 3 beta en glycogen synthase kinase-3 beta en GSK3B en GSK-3 beta en GSK3beta isoform en serine/threonine-protein kinase GSK3B

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ glycogen synthase kinase 3 beta — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ glycogen synthase kinase 3 beta — physically interacts with (P129): tideglusib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. platform.opentargets.org. Provenance: wikidata.org.
[4] ↑ glycogen synthase kinase 3 beta — physically interacts with (P129): tideglusib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[5] ↑ glycogen synthase kinase 3 beta — physically interacts with (P129): lithium citrate. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[6] ↑ glycogen synthase kinase 3 beta — physically interacts with (P129): ly-2090314. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[7] ↑ glycogen synthase kinase 3 beta — EC enzyme number (P591): 2.7.11.1. Q905695. Retrieved 2015-10-12. uniprot.org. Provenance: wikidata.org.

Class ancestry

[1] ↑ glycogen synthase kinase 3 beta is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). glycogen synthase kinase 3 beta. Retrieved May 3, 2026, from https://4ort.xyz/entity/glycogen-synthase-kinase-3-beta-q5514576

MLA

“glycogen synthase kinase 3 beta.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/glycogen-synthase-kinase-3-beta-q5514576.

BibTeX

@misc{4ortxyz_glycogen-synthase-kinase-3-beta-q5514576_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{glycogen synthase kinase 3 beta}}, year = {2026}, url = {https://4ort.xyz/entity/glycogen-synthase-kinase-3-beta-q5514576}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): glycogen synthase kinase 3 beta — https://4ort.xyz/entity/glycogen-synthase-kinase-3-beta-q5514576 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/glycogen-synthase-kinase-3-beta-q5514576 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

5w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → P49841

Umls cui → C0244988

Exact match → http://purl.uniprot.org/uniprot/P49841

Imported from → —

+ 16 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.11.26, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"

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