GATA binding protein 4

mammalian protein found in Mus musculus

Protein protein Q21497814

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Summary

GATA binding protein 4 is a protein^[1].

Key Facts

GATA binding protein 4's instance of is recorded as protein^[2].
GATA binding protein 4's subclass of is recorded as protein^[3].
GATA binding protein 4's UniProt protein ID is recorded as Q08369^[4].
GATA binding protein 4's part of is recorded as Transcription factor GATA-4/5/6^[5].
GATA binding protein 4's part of is recorded as Zinc finger, NHR/GATA-type^[6].
GATA binding protein 4's part of is recorded as GATA-type transcription activator, N-terminal domain, protein family^[7].
GATA binding protein 4's part of is recorded as Zinc finger, GATA-type, protein family^[8].
GATA binding protein 4's has part is recorded as GATA-type transcription activator, N-terminal^[9].
GATA binding protein 4's has part is recorded as Zinc finger, GATA-type^[10].
GATA binding protein 4's RefSeq protein ID is recorded as NP_001297539^[11].
GATA binding protein 4's RefSeq protein ID is recorded as NP_032118^[12].
GATA binding protein 4's RefSeq protein ID is recorded as XP_011243258^[13].
GATA binding protein 4's RefSeq protein ID is recorded as XP_011243259^[14].
GATA binding protein 4's molecular function is recorded as DNA-binding transcription factor activity^[15].
GATA binding protein 4's molecular function is recorded as co-SMAD binding^[16].
GATA binding protein 4's molecular function is recorded as RNA polymerase II transcription regulatory region sequence-specific DNA binding^[17].
GATA binding protein 4's molecular function is recorded as transcription factor binding^[18].
GATA binding protein 4's molecular function is recorded as metal ion binding^[19].
GATA binding protein 4's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[20].
GATA binding protein 4's molecular function is recorded as zinc ion binding^[21].
GATA binding protein 4's molecular function is recorded as chromatin binding^[22].
GATA binding protein 4's molecular function is recorded as protein binding^[23].
GATA binding protein 4's molecular function is recorded as DNA binding^[24].
GATA binding protein 4's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[25].
GATA binding protein 4's molecular function is recorded as transcription coactivator activity^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Transcription factor GATA-4/5/6, Zinc finger, NHR/GATA-type, GATA-type transcription activator, N-terminal domain, protein family, Zinc finger, GATA-type, protein family

Properties

Biological process cardiac septum development, regulation of transcription by RNA polymerase II, outflow tract morphogenesis, transcription by RNA polymerase II, embryonic heart tube development, heart looping, atrial septum morphogenesis, atrial septum primum morphogenesis, positive regulation of cardiac muscle cell proliferation, atrioventricular valve morphogenesis, spermatogenesis, embryonic digestive tract morphogenesis, vasculogenesis involved in coronary vascular morphogenesis, atrioventricular canal development, regulation of cardiac muscle cell proliferation, SMAD protein signal transduction, ventricular septum development, lung lobe formation, cellular response to follicle-stimulating hormone stimulus, cardiac muscle cell differentiation, signal transduction involved in regulation of gene expression, Sertoli cell differentiation, in utero embryonic development, tube morphogenesis, transcription, DNA-templated, positive regulation of transcription, DNA-templated, development of the heart, atrioventricular valve formation, seminiferous tubule development, cardiac muscle hypertrophy in response to stress, intestinal epithelial cell differentiation, positive regulation of cardioblast differentiation, endoderm formation, tricuspid valve formation, male gonad development, response to retinoic acid, embryonic foregut morphogenesis, endocardial cushion development, BMP signaling pathway, positive regulation of angiogenesis, response to estrogen, epithelial cell fate commitment, embryonic heart tube anterior/posterior pattern specification, diaphragm morphogenesis, skeletal muscle cell differentiation, regulation of gene expression, canonical Wnt signaling pathway, cellular response to gonadotropin stimulus, ventricular cardiac muscle tissue development, lung morphogenesis, cardiac muscle tissue development, cell-cell signaling, gastrulation with mouth forming second, heart morphogenesis, atrial septum secundum morphogenesis, embryonic morphogenesis, mitral valve formation, positive regulation of vascular endothelial growth factor production, cardiac right ventricle morphogenesis, positive regulation of transcription by RNA polymerase II, positive regulation of protein phosphorylation, negative regulation of gene expression, cardiac muscle tissue regeneration, positive regulation of gene expression, negative regulation of oxidative stress-induced cell death, negative regulation of apoptotic signaling pathway, regulation of protein kinase B signaling, negative regulation of cardiac muscle cell apoptotic process, positive regulation of ERK1 and ERK2 cascade, negative regulation of connective tissue replacement, negative regulation of apoptotic process, positive regulation of cell cycle, regulation of transcription, DNA-templated, response to mechanical stimulus, negative regulation of autophagy, positive regulation of BMP signaling pathway, transdifferentiation, cell growth involved in cardiac muscle cell development, regulation of cardiac muscle cell contraction, aortic valve morphogenesis, development of the heart, animal organ morphogenesis, tissue development, cell development, anatomical structure formation involved in morphogenesis, positive regulation of transcription by RNA polymerase II, cardiac muscle cell differentiation, digestive tract development, cardiac muscle tissue development

Cell component nucleus, transcription regulator complex, RNA polymerase II transcription regulator complex, nuclear body, nucleus

Encoded by Gata4

Found in taxon house mouse

Has part(s) GATA-type transcription activator, N-terminal, Zinc finger, GATA-type

Imported from wholeness_audit_2026-05-02

Molecular function DNA-binding transcription factor activity, co-SMAD binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, transcription factor binding, metal ion binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, zinc ion binding, chromatin binding, protein binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription coactivator activity, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, DNA-binding transcription factor activity, RNA polymerase II-specific, cis-regulatory region sequence-specific DNA binding, protein kinase binding, sequence-specific DNA binding, NFAT protein binding, DNA-binding transcription factor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (3)

Ensembl protein id ENSMUSP00000113891, ENSMUSP00000066927, ENSMUSP00000113451, ENSMUSP00000114279, ENSMUSP00000114369, ENSMUSP00000121008

Refseq protein id NP_001297539, NP_032118, XP_011243258, XP_011243259

Uniprot protein id Q08369

🏷️ Also known as

en Gata4 en GATA-binding factor 4 en GATA binding protein 4 en transcription factor GATA-4

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ GATA binding protein 4 — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ GATA binding protein 4 — subclass of (P279): protein. UniProt. Retrieved 2017-01-19. wikidata.org.
[4] ↑ GATA binding protein 4 — UniProt protein ID (P352): Q08369. UniProt. Retrieved 2022-05-25. wikidata.org.
[5] ↑ GATA binding protein 4 — part of (P361): Transcription factor GATA-4/5/6. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ GATA binding protein 4 — part of (P361): Zinc finger, NHR/GATA-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ GATA binding protein 4 — part of (P361): GATA-type transcription activator, N-terminal domain, protein family. wikidata.org.
[8] ↑ GATA binding protein 4 — part of (P361): Zinc finger, GATA-type, protein family. wikidata.org.
[9] ↑ GATA binding protein 4 — has part(s) (P527): GATA-type transcription activator, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ GATA binding protein 4 — has part(s) (P527): Zinc finger, GATA-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ GATA binding protein 4 — RefSeq protein ID (P637): NP_001297539. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ GATA binding protein 4 — RefSeq protein ID (P637): NP_032118. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ GATA binding protein 4 — RefSeq protein ID (P637): XP_011243258. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ GATA binding protein 4 — RefSeq protein ID (P637): XP_011243259. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ GATA binding protein 4 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ GATA binding protein 4 — molecular function (P680): co-SMAD binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ GATA binding protein 4 — molecular function (P680): RNA polymerase II transcription regulatory region sequence-specific DNA binding. Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ GATA binding protein 4 — molecular function (P680): transcription factor binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ GATA binding protein 4 — molecular function (P680): metal ion binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ GATA binding protein 4 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ GATA binding protein 4 — molecular function (P680): zinc ion binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ GATA binding protein 4 — molecular function (P680): chromatin binding. The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5, Srf, Histone Modifications, and MicroRNAs. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ GATA binding protein 4 — molecular function (P680): protein binding. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ GATA binding protein 4 — molecular function (P680): DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ GATA binding protein 4 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ GATA binding protein 4 — molecular function (P680): transcription coactivator activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ GATA binding protein 4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_gata-binding-protein-4-q21497814_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{GATA binding protein 4}}, year = {2026}, url = {https://4ort.xyz/entity/gata-binding-protein-4-q21497814}, note = {Accessed: 2026-05-03}}

LLM prompt

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