GATA binding protein 4

mammalian protein found in Homo sapiens

Protein protein Q21101542

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GATA binding protein 4

Summary

GATA binding protein 4 is a protein^[1].

Key Facts

GATA binding protein 4's instance of is recorded as protein^[2].
GATA binding protein 4's UniProt protein ID is recorded as P43694^[3].
GATA binding protein 4's part of is recorded as Transcription factor GATA-4/5/6^[4].
GATA binding protein 4's part of is recorded as Zinc finger, NHR/GATA-type^[5].
GATA binding protein 4's part of is recorded as GATA-type transcription activator, N-terminal domain, protein family^[6].
GATA binding protein 4's part of is recorded as Zinc finger, GATA-type, protein family^[7].
GATA binding protein 4's MeSH descriptor ID is recorded as D050991^[8].
GATA binding protein 4's has part is recorded as Zinc finger, GATA-type^[9].
GATA binding protein 4's has part is recorded as GATA-type transcription activator, N-terminal^[10].
GATA binding protein 4's RefSeq protein ID is recorded as NP_001295022^[11].
GATA binding protein 4's RefSeq protein ID is recorded as NP_001295023^[12].
GATA binding protein 4's RefSeq protein ID is recorded as NP_002043^[13].
GATA binding protein 4's RefSeq protein ID is recorded as XP_005272442^[14].
GATA binding protein 4's RefSeq protein ID is recorded as XP_011542119^[15].
GATA binding protein 4's RefSeq protein ID is recorded as XP_011542120^[16].
GATA binding protein 4's RefSeq protein ID is recorded as NP_001361202^[17].
GATA binding protein 4's RefSeq protein ID is recorded as NP_001361203^[18].
GATA binding protein 4's PDB structure ID is recorded as 2M9W^[19].
GATA binding protein 4's MeSH tree code is recorded as D12.776.260.257.400^[20].
GATA binding protein 4's MeSH tree code is recorded as D12.776.930.314.400^[21].
GATA binding protein 4's molecular function is recorded as DNA binding^[22].
GATA binding protein 4's molecular function is recorded as sequence-specific DNA binding^[23].
GATA binding protein 4's molecular function is recorded as co-SMAD binding^[24].
GATA binding protein 4's molecular function is recorded as DNA-binding transcription factor activity^[25].
GATA binding protein 4's molecular function is recorded as transcription coactivator activity^[26].

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Quick Facts

Instance of protein

Part of Transcription factor GATA-4/5/6, Zinc finger, NHR/GATA-type, GATA-type transcription activator, N-terminal domain, protein family, Zinc finger, GATA-type, protein family

Properties

Biological process endoderm development, male gonad development, regulation of transcription, DNA-templated, ventricular septum development, cell growth involved in cardiac muscle cell development, embryonic foregut morphogenesis, endocardial cushion development, cardiac muscle cell differentiation, cell-cell signaling, response to mechanical stimulus, blood coagulation, transcription by RNA polymerase II, transcription, DNA-templated, positive regulation of angiogenesis, positive regulation of transcription, DNA-templated, heart looping, atrial septum morphogenesis, response to vitamin A, regulation of cardiac muscle cell contraction, atrial septum secundum morphogenesis, atrial septum primum morphogenesis, intestinal epithelial cell differentiation, embryonic heart tube anterior/posterior pattern specification, positive regulation of BMP signaling pathway, positive regulation of cardioblast differentiation, positive regulation of vascular endothelial growth factor production, negative regulation of autophagy, cardiac ventricle morphogenesis, cardiac right ventricle morphogenesis, cellular response to glucose stimulus, positive regulation of transcription by RNA polymerase II, transdifferentiation, aortic valve morphogenesis, development of the heart, animal organ morphogenesis, tissue development, cell development, anatomical structure formation involved in morphogenesis, positive regulation of transcription by RNA polymerase II, cardiac muscle cell differentiation, digestive tract development, cardiac muscle tissue development, atrioventricular valve formation, negative regulation of cardiac muscle cell apoptotic process, regulation of protein kinase B signaling, cardiac muscle tissue regeneration, positive regulation of ERK1 and ERK2 cascade, negative regulation of oxidative stress-induced cell death, negative regulation of apoptotic signaling pathway

Cell component nucleoplasm, RNA polymerase II transcription regulator complex, nucleus, nuclear body, nucleus

Encoded by GATA4

Found in taxon Homo sapiens

Has part(s) Zinc finger, GATA-type, GATA-type transcription activator, N-terminal

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, sequence-specific DNA binding, co-SMAD binding, DNA-binding transcription factor activity, transcription coactivator activity, zinc ion binding, transcription factor binding, chromatin binding, metal ion binding, protein binding, cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, protein kinase binding, NFAT protein binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (7)

Ensembl protein id ENSP00000334458, ENSP00000435712, ENSP00000432278, ENSP00000435043, ENSP00000435347, ENSP00000473598, ENSP00000473671, ENSP00000482268, ENSP00000494427, ENSP00000495511, ENSP00000493647, ENSP00000496486, ENSP00000496575, ENSP00000494090, ENSP00000494491, ENSP00000496386

Mesh descriptor id D050991

Mesh tree code D12.776.260.257.400, D12.776.930.314.400

Pdb structure id 2M9W

Refseq protein id NP_001295022, NP_001295023, NP_002043, XP_005272442, XP_011542119, XP_011542120, NP_001361202, NP_001361203

Umls cui C0214550

Uniprot protein id P43694

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ GATA binding protein 4 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ GATA binding protein 4 — UniProt protein ID (P352): P43694. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ GATA binding protein 4 — part of (P361): Transcription factor GATA-4/5/6. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ GATA binding protein 4 — part of (P361): Zinc finger, NHR/GATA-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ GATA binding protein 4 — part of (P361): GATA-type transcription activator, N-terminal domain, protein family. wikidata.org.
[7] ↑ GATA binding protein 4 — part of (P361): Zinc finger, GATA-type, protein family. wikidata.org.
[8] ↑ GATA binding protein 4 — MeSH descriptor ID (P486): D050991. wikidata.org.
[9] ↑ GATA binding protein 4 — has part(s) (P527): Zinc finger, GATA-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ GATA binding protein 4 — has part(s) (P527): GATA-type transcription activator, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ GATA binding protein 4 — RefSeq protein ID (P637): NP_001295022. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ GATA binding protein 4 — RefSeq protein ID (P637): NP_001295023. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ GATA binding protein 4 — RefSeq protein ID (P637): NP_002043. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ GATA binding protein 4 — RefSeq protein ID (P637): XP_005272442. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ GATA binding protein 4 — RefSeq protein ID (P637): XP_011542119. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ GATA binding protein 4 — RefSeq protein ID (P637): XP_011542120. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ GATA binding protein 4 — RefSeq protein ID (P637): NP_001361202. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ GATA binding protein 4 — RefSeq protein ID (P637): NP_001361203. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ GATA binding protein 4 — PDB structure ID (P638): 2M9W. Q905695. Retrieved 2016-03-21. wikidata.org.
[20] ↑ GATA binding protein 4 — MeSH tree code (P672): D12.776.260.257.400. wikidata.org.
[21] ↑ GATA binding protein 4 — MeSH tree code (P672): D12.776.930.314.400. wikidata.org.
[22] ↑ GATA binding protein 4 — molecular function (P680): DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ GATA binding protein 4 — molecular function (P680): sequence-specific DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ GATA binding protein 4 — molecular function (P680): co-SMAD binding. Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ GATA binding protein 4 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ GATA binding protein 4 — molecular function (P680): transcription coactivator activity. Loss-of-function mutation in GATA4 causes anomalies of human testicular development. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ GATA binding protein 4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_gata-binding-protein-4-q21101542_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{GATA binding protein 4}}, year = {2026}, url = {https://4ort.xyz/entity/gata-binding-protein-4-q21101542}, note = {Accessed: 2026-05-03}}

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