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fumarate hydratase

mammalian protein found in Homo sapiens
Protein protein Q21107515

Facts

10 properties
Instance of
protein
Part of
Fumarase/histidase, N-terminal, L-Aspartase-like, Fumarate hydratase, class II, FH tetramer [mitochondrial matrix], Fumarase C, C-terminal domain, protein family, Fumarate lyase, N-terminal domain, protein family, Fumarate lyase, conserved site, protein family[1][2][3][4][5][6][7]
Biological process
homeostasis of number of cells within a tissue, tricarboxylic acid cycle, malate metabolic process, fumarate metabolic process, positive regulation of cold-induced thermogenesis[21][22][23][24][25]
Cell component
cytoplasm, tricarboxylic acid cycle enzyme complex, mitochondrial matrix, extracellular exosome, mitochondrion, mitochondrion, extracellular exosome[16][17][18][19][20]
EC enzyme number
4.2.1.2[11]
Encoded by
FH[26]
Found in taxon
Homo sapiens[27]
Has part(s)
Fumarase C, C-terminal, Fumarate lyase, conserved site, Fumarate lyase, N-terminal[8][9][10]
Molecular function
protein binding, catalytic activity, lyase activity, fumarate hydratase activity, fumarate hydratase activity[12][13][14][15]
Product or material produced
DL-malic acid[28]
🏷️ Also known as
en fumarate hydratase, mitochondrial en EF-3 en epididymis secretory sperm binding protein en FH en fumarase en fumarate hydratase cs Fumaráza es Fumarasa fa فوماراز fi Fumaraasi hu Fumaráz it Fumarato idratasi ja フマル酸ヒドラターゼ ko 푸마라아제 pl Fumaraza ro fumarază uk Фумаратгідратаза vi enzyme fumarase vi FH vi fumarase
🔖 Identifiers · 12
OpenAlex ID
C106302636
Image (Wikimedia Commons)
Fumarase 3e04.png ↗
Ensembl protein ID
ENSP00000355518
Exact match
identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov
Freebase ID
/m/0bdj87
MeSH descriptor ID
D005649
MeSH tree code
D08.811.520.241.300.300
Microsoft Academic ID (discontinued)
106302636
PDB structure ID
3E04
RefSeq protein ID
NP_000134, XP_011542434
UMLS CUI
C0016799
UniProt protein ID
P07954

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🔗 Connections
Cell component 6
mitochondrion, mitochondrion, cytoplasm, extracellular exosome, extracellular exosome, mitochondrial matrix
Molecular function 2
protein binding, catalytic activity
Biological process 1
tricarboxylic acid cycle
Found in taxon 1
Homo sapiens
Instance of 1
protein
Product or material produced 1
DL-malic acid
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References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [4] ↑ . wikidata.org.
  5. [5] ↑ . wikidata.org.
  6. [6] ↑ . wikidata.org.
  7. [7] ↑ . wikidata.org.
  8. [8] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [9] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [11] ↑ . UniProt. Retrieved . wikidata.org.
  12. [12] ↑ . Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [15] ↑ . Nucleotide sequence of a cDNA coding for mitochondrial fumarase from human liver. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [16] ↑ . Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [19] ↑ . MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [20] ↑ . Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [23] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [24] ↑ . Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [25] ↑ . Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin Resistance. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [26] ↑ . UniProt. Retrieved . wikidata.org.
  27. [27] ↑ . UniProt. Retrieved . wikidata.org.
  28. [28] ↑ . wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). fumarate hydratase. Retrieved November 3, 2026, from https://4ort.xyz/entity/fumarate-hydratase
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BibTeX @misc{4ortxyz_fumarate-hydratase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{fumarate hydratase}}, year = {2026}, url = {https://4ort.xyz/entity/fumarate-hydratase}, note = {Accessed: 2026-11-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 14w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    EC enzyme number → 4.2.1.2
    "/* wbcreateclaim-create:1| */ EC enzyme number: 4.2.1.2, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
  2. 15w ago · Dirac · 2026-07-20 view diff on Wikidata ↗
    Molecular function → protein binding, catalytic activity, lyase activity +2
    Part of → —
    Cell component → cytoplasm, tricarboxylic acid cycle enzyme complex, mitochondrial matrix +4
    Instance of → protein
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Image: Fumarase 3e04.png, [[:toollabs:quickstatements/#/batch/261337|batch #261337]]"
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