Forkhead box P3

mammalian protein found in Mus musculus

Protein protein Q14865673

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Forkhead box P3

Summary

Forkhead box P3 is a protein^[1].

Key Facts

Forkhead box P3's instance of is recorded as protein^[2].
Forkhead box P3's subclass of is recorded as protein^[3].
Forkhead box P3's UniProt protein ID is recorded as Q99JB6^[4].
Forkhead box P3's part of is recorded as winged helix DNA-binding domain superfamily^[5].
Forkhead box P3's part of is recorded as Winged helix-like DNA-binding domain superfamily^[6].
Forkhead box P3's part of is recorded as FOXP, coiled-coil domain, protein family^[7].
Forkhead box P3's part of is recorded as Zinc finger C2H2-type, protein family^[8].
Forkhead box P3's part of is recorded as Fork head domain, protein family^[9].
Forkhead box P3's part of is recorded as Fork head domain conserved site 2, protein family^[10].
Forkhead box P3's has part is recorded as Fork head domain conserved site 2^[11].
Forkhead box P3's has part is recorded as FOXP, coiled-coil domain^[12].
Forkhead box P3's has part is recorded as Fork head domain^[13].
Forkhead box P3's has part is recorded as Zinc finger C2H2-type^[14].
Forkhead box P3's RefSeq protein ID is recorded as NP_001186276^[15].
Forkhead box P3's RefSeq protein ID is recorded as NP_001186277^[16].
Forkhead box P3's RefSeq protein ID is recorded as NP_473380^[17].
Forkhead box P3's PDB structure ID is recorded as 4I1L^[18].
Forkhead box P3's molecular function is recorded as NFAT protein binding^[19].
Forkhead box P3's molecular function is recorded as sequence-specific DNA binding^[20].
Forkhead box P3's molecular function is recorded as protein homodimerization activity^[21].
Forkhead box P3's molecular function is recorded as transcription corepressor activity^[22].
Forkhead box P3's molecular function is recorded as DNA-binding transcription factor activity^[23].
Forkhead box P3's molecular function is recorded as histone deacetylase binding^[24].
Forkhead box P3's molecular function is recorded as metal ion binding^[25].
Forkhead box P3's molecular function is recorded as protein binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of winged helix DNA-binding domain superfamily, Winged helix-like DNA-binding domain superfamily, FOXP, coiled-coil domain, protein family, Zinc finger C2H2-type, protein family, Fork head domain, protein family, Fork head domain conserved site 2, protein family

Properties

Biological process negative regulation of interleukin-10 production, T cell mediated immunity, tolerance induction to self antigen, negative regulation of histone deacetylation, negative regulation of interferon-gamma production, negative regulation of interleukin-5 production, positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, regulation of transcription, DNA-templated, regulation of isotype switching to IgG isotypes, regulatory T cell differentiation, negative regulation of interleukin-4 production, positive regulation of immature T cell proliferation in thymus, regulation of transcription by RNA polymerase II, positive regulation of regulatory T cell differentiation, negative regulation of interleukin-6 production, myeloid cell homeostasis, cytokine production, negative regulation of CREB transcription factor activity, positive regulation of peripheral T cell tolerance induction, response to virus, negative regulation of isotype switching to IgE isotypes, B cell homeostasis, negative regulation of transcription by RNA polymerase II, positive regulation of T cell tolerance induction, negative regulation of chronic inflammatory response, negative regulation of gene expression, transcription, DNA-templated, positive regulation of interleukin-4 production, negative regulation of DNA-binding transcription factor activity, positive regulation of histone acetylation, negative regulation of lymphocyte proliferation, positive regulation of transcription, DNA-templated, positive regulation of transforming growth factor beta1 production, negative regulation of T cell proliferation, positive regulation of gene expression, negative regulation of immune response, positive regulation of T cell anergy, negative regulation of T cell cytokine production, CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment, tolerance induction, regulation of T cell anergy, negative regulation of tumor necrosis factor production, negative regulation of interleukin-17 production, negative regulation of transcription, DNA-templated, negative regulation of NF-kappaB transcription factor activity, regulation of immunoglobulin production, negative regulation of interleukin-2 production, negative regulation of histone acetylation, negative regulation of inflammatory response, T cell receptor signaling pathway, T cell activation, negative regulation of T-helper 17 cell differentiation, positive regulation of transcription by RNA polymerase II, negative regulation of cell population proliferation, CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, anatomical structure morphogenesis, CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, positive regulation of regulatory T cell differentiation

Cell component cytoplasm, intracellular anatomical structure, nucleus, nucleoplasm

Encoded by Foxp3

Found in taxon house mouse

Has part(s) Fork head domain conserved site 2, FOXP, coiled-coil domain, Fork head domain, Zinc finger C2H2-type

Imported from wholeness_audit_2026-05-02

Molecular function NFAT protein binding, sequence-specific DNA binding, protein homodimerization activity, transcription corepressor activity, DNA-binding transcription factor activity, histone deacetylase binding, metal ion binding, protein binding, histone acetyltransferase binding, nucleic acid binding, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (4)

Ensembl protein id ENSMUSP00000041953, ENSMUSP00000111403, ENSMUSP00000111404, ENSMUSP00000111405

Pdb structure id 4I1L

Refseq protein id NP_001186276, NP_001186277, NP_473380

Uniprot protein id Q99JB6

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Forkhead box P3 — instance of (P31): protein. Q905695. Retrieved 2018-09-12. wikidata.org.
[3] ↑ Forkhead box P3 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Forkhead box P3 — UniProt protein ID (P352): Q99JB6. Q905695. Retrieved 2018-09-12. wikidata.org.
[5] ↑ Forkhead box P3 — part of (P361): winged helix DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Forkhead box P3 — part of (P361): Winged helix-like DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Forkhead box P3 — part of (P361): FOXP, coiled-coil domain, protein family. wikidata.org.
[8] ↑ Forkhead box P3 — part of (P361): Zinc finger C2H2-type, protein family. wikidata.org.
[9] ↑ Forkhead box P3 — part of (P361): Fork head domain, protein family. wikidata.org.
[10] ↑ Forkhead box P3 — part of (P361): Fork head domain conserved site 2, protein family. wikidata.org.
[11] ↑ Forkhead box P3 — has part(s) (P527): Fork head domain conserved site 2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Forkhead box P3 — has part(s) (P527): FOXP, coiled-coil domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Forkhead box P3 — has part(s) (P527): Fork head domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Forkhead box P3 — has part(s) (P527): Zinc finger C2H2-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Forkhead box P3 — RefSeq protein ID (P637): NP_001186276. Q20641742. Retrieved 2018-09-14. wikidata.org.
[16] ↑ Forkhead box P3 — RefSeq protein ID (P637): NP_001186277. Q20641742. Retrieved 2018-09-14. wikidata.org.
[17] ↑ Forkhead box P3 — RefSeq protein ID (P637): NP_473380. Q20641742. Retrieved 2018-09-14. wikidata.org.
[18] ↑ Forkhead box P3 — PDB structure ID (P638): 4I1L. Q905695. Retrieved 2016-08-09. wikidata.org.
[19] ↑ Forkhead box P3 — molecular function (P680): NFAT protein binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Forkhead box P3 — molecular function (P680): sequence-specific DNA binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Forkhead box P3 — molecular function (P680): protein homodimerization activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Forkhead box P3 — molecular function (P680): transcription corepressor activity. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Forkhead box P3 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Forkhead box P3 — molecular function (P680): histone deacetylase binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Forkhead box P3 — molecular function (P680): metal ion binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Forkhead box P3 — molecular function (P680): protein binding. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Forkhead box P3 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Forkhead box P3. Retrieved May 3, 2026, from https://4ort.xyz/entity/forkhead-box-p3-q14865673

MLA

“Forkhead box P3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/forkhead-box-p3-q14865673.

BibTeX

@misc{4ortxyz_forkhead-box-p3-q14865673_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Forkhead box P3}}, year = {2026}, url = {https://4ort.xyz/entity/forkhead-box-p3-q14865673}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Forkhead box P3 — https://4ort.xyz/entity/forkhead-box-p3-q14865673 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/forkhead-box-p3-q14865673 · Last refreshed: May 3, 2026