Forkhead box P3
mammalian protein found in Mus musculus
Facts
9 properties- Instance of
- protein
- Part of
- winged helix DNA-binding domain superfamily, Winged helix-like DNA-binding domain superfamily, FOXP, coiled-coil domain, protein family, Zinc finger C2H2-type, protein family, Fork head domain, protein family, Fork head domain conserved site 2, protein family[3][4][5][6][7][8]
- Biological process
- negative regulation of interleukin-10 production, T cell mediated immunity, tolerance induction to self antigen, negative regulation of histone deacetylation, negative regulation of interferon-gamma production, negative regulation of interleukin-5 production, positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, regulation of transcription, DNA-templated, regulation of isotype switching to IgG isotypes, regulatory T cell differentiation, negative regulation of interleukin-4 production, positive regulation of immature T cell proliferation in thymus, regulation of transcription by RNA polymerase II, positive regulation of regulatory T cell differentiation, negative regulation of interleukin-6 production, myeloid cell homeostasis, cytokine production, negative regulation of CREB transcription factor activity, positive regulation of peripheral T cell tolerance induction, response to virus, negative regulation of isotype switching to IgE isotypes, B cell homeostasis, negative regulation of transcription by RNA polymerase II, positive regulation of T cell tolerance induction, negative regulation of chronic inflammatory response, negative regulation of gene expression, transcription, DNA-templated, positive regulation of interleukin-4 production, negative regulation of DNA-binding transcription factor activity, positive regulation of histone acetylation, negative regulation of lymphocyte proliferation, positive regulation of transcription, DNA-templated, positive regulation of transforming growth factor beta1 production, negative regulation of T cell proliferation, positive regulation of gene expression, negative regulation of immune response, positive regulation of T cell anergy, negative regulation of T cell cytokine production, CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment, tolerance induction, regulation of T cell anergy, negative regulation of tumor necrosis factor production, negative regulation of interleukin-17 production, negative regulation of transcription, DNA-templated, negative regulation of NF-kappaB transcription factor activity, regulation of immunoglobulin production, negative regulation of interleukin-2 production, negative regulation of histone acetylation, negative regulation of inflammatory response, T cell receptor signaling pathway, T cell activation, negative regulation of T-helper 17 cell differentiation, positive regulation of transcription by RNA polymerase II, negative regulation of cell population proliferation, CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, anatomical structure morphogenesis, CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, positive regulation of regulatory T cell differentiation
- Cell component
- cytoplasm, intracellular anatomical structure, nucleus, nucleoplasm
- Encoded by
- Foxp3
- Found in taxon
- house mouse
- Has part(s)
- Fork head domain conserved site 2, FOXP, coiled-coil domain, Fork head domain, Zinc finger C2H2-type[9][10][11][12]
- Molecular function
- NFAT protein binding, sequence-specific DNA binding, protein homodimerization activity, transcription corepressor activity, DNA-binding transcription factor activity, histone deacetylase binding, metal ion binding, protein binding, histone acetyltransferase binding, nucleic acid binding, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific[13][14][15][16][17][18][19][20]
🏷️ Also known as
en Forkhead box P3
en forkhead box protein P3
en Foxp3
en Scurfin
en scurfy
🔖 Identifiers · 4
- Ensembl protein ID
- ENSMUSP00000041953, ENSMUSP00000111403, ENSMUSP00000111404, ENSMUSP00000111405
- PDB structure ID
- 4I1L
- RefSeq protein ID
- NP_001186276, NP_001186277, NP_473380
- UniProt protein ID
- Q99JB6
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Summary
Forkhead box P3 is a protein[1].