Forkhead box O3

mammalian protein found in Mus musculus

Protein protein Q21981986

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Forkhead box O3

Summary

Forkhead box O3 is a protein^[1].

Key Facts

Forkhead box O3's instance of is recorded as protein^[2].
Forkhead box O3's UniProt protein ID is recorded as Q9WVH4^[3].
Forkhead box O3's part of is recorded as winged helix DNA-binding domain superfamily^[4].
Forkhead box O3's part of is recorded as Winged helix-like DNA-binding domain superfamily^[5].
Forkhead box O3's part of is recorded as FOXO protein, KIX-binding domain^[6].
Forkhead box O3's part of is recorded as membrane protein^[7].
Forkhead box O3's part of is recorded as FOXO protein, transactivation domain, protein family^[8].
Forkhead box O3's part of is recorded as Fork head domain, protein family^[9].
Forkhead box O3's part of is recorded as Fork head domain conserved site 2, protein family^[10].
Forkhead box O3's has part is recorded as Fork head domain^[11].
Forkhead box O3's has part is recorded as FOXO protein, transactivation domain^[12].
Forkhead box O3's has part is recorded as Fork head domain conserved site 2^[13].
Forkhead box O3's RefSeq protein ID is recorded as NP_062714^[14].
Forkhead box O3's RefSeq protein ID is recorded as NP_001363896^[15].
Forkhead box O3's molecular function is recorded as DNA binding^[16].
Forkhead box O3's molecular function is recorded as sequence-specific DNA binding^[17].
Forkhead box O3's molecular function is recorded as beta-catenin binding^[18].
Forkhead box O3's molecular function is recorded as DNA-binding transcription factor activity^[19].
Forkhead box O3's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[20].
Forkhead box O3's molecular function is recorded as protein binding^[21].
Forkhead box O3's molecular function is recorded as DNA-binding transcription repressor activity, RNA polymerase II-specific^[22].
Forkhead box O3's molecular function is recorded as chromatin DNA binding^[23].
Forkhead box O3's molecular function is recorded as protein kinase binding^[24].
Forkhead box O3's molecular function is recorded as transcription coregulator binding^[25].
Forkhead box O3's molecular function is recorded as mitochondrial transcription factor activity^[26].

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Quick Facts

Instance of protein

Part of winged helix DNA-binding domain superfamily, Winged helix-like DNA-binding domain superfamily, FOXO protein, KIX-binding domain, membrane protein, FOXO protein, transactivation domain, protein family, Fork head domain, protein family, Fork head domain conserved site 2, protein family

Properties

Biological process initiation of primordial ovarian follicle growth, ovulation from ovarian follicle, regulation of transcription, DNA-templated, antral ovarian follicle growth, positive regulation of erythrocyte differentiation, glucose homeostasis, regulation of transcription by RNA polymerase II, DNA damage response, signal transduction by p53 class mediator, tumor necrosis factor-mediated signaling pathway, negative regulation of transcription by RNA polymerase II, regulation of reactive oxygen species metabolic process, transcription, DNA-templated, regulation of neural precursor cell proliferation, neuronal stem cell population maintenance, positive regulation of transcription, DNA-templated, positive regulation of neuron apoptotic process, oocyte maturation, extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of apoptotic process, regulation of translation, negative regulation of canonical Wnt signaling pathway, positive regulation of transcription by RNA polymerase II, apoptotic process, cellular response to corticosterone stimulus, cellular response to hypoxia, cellular response to nerve growth factor stimulus, response to nutrient levels, cellular response to amyloid-beta, response to dexamethasone, cellular response to glucose stimulus, cellular response to oxidative stress, brain morphogenesis, response to water-immersion restraint stress, transcription by RNA polymerase II, mitochondrial transcription, ageing, negative regulation of neuron differentiation, positive regulation of hydrogen peroxide-mediated programmed cell death, positive regulation of reactive oxygen species biosynthetic process, positive regulation of endothelial cell apoptotic process, negative regulation of cell migration, negative regulation of cell migration, negative regulation of transcription by RNA polymerase II, insulin receptor signaling pathway, glucose homeostasis, positive regulation of transcription by RNA polymerase II, positive regulation of autophagy, positive regulation of muscle atrophy, response to starvation

Cell component cytoplasm, cytosol, membrane, nucleoplasm, nucleus, mitochondrion, mitochondrial outer membrane, mitochondrial matrix, protein-containing complex, membrane, nucleus, cytoplasm, nucleoplasm, cytosol

Encoded by Foxo3

Found in taxon house mouse

Has part(s) Fork head domain, FOXO protein, transactivation domain, Fork head domain conserved site 2

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, sequence-specific DNA binding, beta-catenin binding, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, protein binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, chromatin DNA binding, protein kinase binding, transcription coregulator binding, mitochondrial transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, transcription factor binding, sequence-specific DNA binding

External References (3)

Ensembl protein id ENSMUSP00000050683, ENSMUSP00000101141, ENSMUSP00000135380, ENSMUSP00000101140, ENSMUSP00000135355

Refseq protein id NP_062714, NP_001363896

Uniprot protein id Q9WVH4

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Forkhead box O3 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Forkhead box O3 — UniProt protein ID (P352): Q9WVH4. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Forkhead box O3 — part of (P361): winged helix DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Forkhead box O3 — part of (P361): Winged helix-like DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Forkhead box O3 — part of (P361): FOXO protein, KIX-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Forkhead box O3 — part of (P361): membrane protein. wikidata.org.
[8] ↑ Forkhead box O3 — part of (P361): FOXO protein, transactivation domain, protein family. wikidata.org.
[9] ↑ Forkhead box O3 — part of (P361): Fork head domain, protein family. wikidata.org.
[10] ↑ Forkhead box O3 — part of (P361): Fork head domain conserved site 2, protein family. wikidata.org.
[11] ↑ Forkhead box O3 — has part(s) (P527): Fork head domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Forkhead box O3 — has part(s) (P527): FOXO protein, transactivation domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Forkhead box O3 — has part(s) (P527): Fork head domain conserved site 2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Forkhead box O3 — RefSeq protein ID (P637): NP_062714. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Forkhead box O3 — RefSeq protein ID (P637): NP_001363896. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Forkhead box O3 — molecular function (P680): DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Forkhead box O3 — molecular function (P680): sequence-specific DNA binding. GOA. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Forkhead box O3 — molecular function (P680): beta-catenin binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Forkhead box O3 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Forkhead box O3 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Forkhead box O3 — molecular function (P680): protein binding. Novel repressor regulates insulin sensitivity through interaction with Foxo1. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Forkhead box O3 — molecular function (P680): DNA-binding transcription repressor activity, RNA polymerase II-specific. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Forkhead box O3 — molecular function (P680): chromatin DNA binding. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Forkhead box O3 — molecular function (P680): protein kinase binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Forkhead box O3 — molecular function (P680): transcription coregulator binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Forkhead box O3 — molecular function (P680): mitochondrial transcription factor activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Forkhead box O3 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Forkhead box O3. Retrieved May 3, 2026, from https://4ort.xyz/entity/forkhead-box-o3-q21981986

MLA

“Forkhead box O3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/forkhead-box-o3-q21981986.

BibTeX

@misc{4ortxyz_forkhead-box-o3-q21981986_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Forkhead box O3}}, year = {2026}, url = {https://4ort.xyz/entity/forkhead-box-o3-q21981986}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Forkhead box O3 — https://4ort.xyz/entity/forkhead-box-o3-q21981986 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/forkhead-box-o3-q21981986 · Last refreshed: May 3, 2026