Forkhead box O1

mammalian protein found in Mus musculus

Protein protein Q21496900

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Forkhead box O1

Summary

Forkhead box O1 is a protein^[1].

Key Facts

Forkhead box O1's instance of is recorded as protein^[2].
Forkhead box O1's subclass of is recorded as protein^[3].
Forkhead box O1's UniProt protein ID is recorded as Q9R1E0^[4].
Forkhead box O1's part of is recorded as winged helix DNA-binding domain superfamily^[5].
Forkhead box O1's part of is recorded as Winged helix-like DNA-binding domain superfamily^[6].
Forkhead box O1's part of is recorded as FOXO protein, KIX-binding domain^[7].
Forkhead box O1's part of is recorded as FOXO protein, transactivation domain, protein family^[8].
Forkhead box O1's part of is recorded as Fork head domain, protein family^[9].
Forkhead box O1's part of is recorded as Fork head domain conserved site 2, protein family^[10].
Forkhead box O1's has part is recorded as Fork head domain^[11].
Forkhead box O1's has part is recorded as FOXO protein, transactivation domain^[12].
Forkhead box O1's has part is recorded as Fork head domain conserved site 2^[13].
Forkhead box O1's RefSeq protein ID is recorded as NP_062713^[14].
Forkhead box O1's molecular function is recorded as DNA binding^[15].
Forkhead box O1's molecular function is recorded as sequence-specific DNA binding^[16].
Forkhead box O1's molecular function is recorded as beta-catenin binding^[17].
Forkhead box O1's molecular function is recorded as transcription factor binding^[18].
Forkhead box O1's molecular function is recorded as DNA-binding transcription repressor activity, RNA polymerase II-specific^[19].
Forkhead box O1's molecular function is recorded as protein binding^[20].
Forkhead box O1's molecular function is recorded as DNA-binding transcription repressor activity, RNA polymerase II-specific^[21].
Forkhead box O1's molecular function is recorded as protein phosphatase 2A binding^[22].
Forkhead box O1's molecular function is recorded as ubiquitin protein ligase binding^[23].
Forkhead box O1's molecular function is recorded as transcription coactivator binding^[24].
Forkhead box O1's molecular function is recorded as DNA-binding transcription factor activity^[25].
Forkhead box O1's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of winged helix DNA-binding domain superfamily, Winged helix-like DNA-binding domain superfamily, FOXO protein, KIX-binding domain, FOXO protein, transactivation domain, protein family, Fork head domain, protein family, Fork head domain conserved site 2, protein family

Properties

Biological process insulin receptor signaling pathway, negative regulation of fat cell differentiation, regulation of transcription, DNA-templated, positive regulation of protein catabolic process, glucose homeostasis, positive regulation of autophagy, cellular response to hyperoxia, cellular response to starvation, negative regulation of apoptotic process, regulation of reactive oxygen species metabolic process, transcription, DNA-templated, regulation of neural precursor cell proliferation, cellular response to dexamethasone stimulus, cellular response to DNA damage stimulus, neuronal stem cell population maintenance, autophagy, positive regulation of transcription, DNA-templated, response to insulin, blood vessel development, response to fluoride, regulation of cell population proliferation, cellular response to insulin stimulus, positive regulation of apoptotic process, negative regulation of stress-activated MAPK cascade, cellular response to oxidative stress, cellular response to nitric oxide, enamel mineralization, positive regulation of gluconeogenesis, negative regulation of canonical Wnt signaling pathway, positive regulation of transcription by RNA polymerase II, cellular response to hydrogen peroxide, apoptotic process, cell differentiation, negative regulation of transcription by RNA polymerase II, anatomical structure morphogenesis, regulation of transcription by RNA polymerase II, negative regulation of cardiac muscle hypertrophy in response to stress, negative regulation of transcription by RNA polymerase II, insulin receptor signaling pathway, glucose homeostasis, positive regulation of transcription by RNA polymerase II

Cell component cytoplasm, nucleus, cytosol, nucleus, cytoplasm, nucleoplasm

Encoded by Foxo1

Found in taxon house mouse

Has part(s) Fork head domain, FOXO protein, transactivation domain, Fork head domain conserved site 2

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, sequence-specific DNA binding, beta-catenin binding, transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, protein binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, protein phosphatase 2A binding, ubiquitin protein ligase binding, transcription coactivator binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, transcription factor binding, sequence-specific DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific

External References (3)

Ensembl protein id ENSMUSP00000055308

Refseq protein id NP_062713

Uniprot protein id Q9R1E0

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Forkhead box O1 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Forkhead box O1 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Forkhead box O1 — UniProt protein ID (P352): Q9R1E0. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Forkhead box O1 — part of (P361): winged helix DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Forkhead box O1 — part of (P361): Winged helix-like DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Forkhead box O1 — part of (P361): FOXO protein, KIX-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Forkhead box O1 — part of (P361): FOXO protein, transactivation domain, protein family. wikidata.org.
[9] ↑ Forkhead box O1 — part of (P361): Fork head domain, protein family. wikidata.org.
[10] ↑ Forkhead box O1 — part of (P361): Fork head domain conserved site 2, protein family. wikidata.org.
[11] ↑ Forkhead box O1 — has part(s) (P527): Fork head domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Forkhead box O1 — has part(s) (P527): FOXO protein, transactivation domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Forkhead box O1 — has part(s) (P527): Fork head domain conserved site 2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Forkhead box O1 — RefSeq protein ID (P637): NP_062713. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Forkhead box O1 — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Forkhead box O1 — molecular function (P680): sequence-specific DNA binding. GOA. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Forkhead box O1 — molecular function (P680): beta-catenin binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Forkhead box O1 — molecular function (P680): transcription factor binding. SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Forkhead box O1 — molecular function (P680): DNA-binding transcription repressor activity, RNA polymerase II-specific. Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Forkhead box O1 — molecular function (P680): protein binding. Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Forkhead box O1 — molecular function (P680): DNA-binding transcription repressor activity, RNA polymerase II-specific. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Forkhead box O1 — molecular function (P680): protein phosphatase 2A binding. The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Forkhead box O1 — molecular function (P680): ubiquitin protein ligase binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Forkhead box O1 — molecular function (P680): transcription coactivator binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Forkhead box O1 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Forkhead box O1 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Forkhead box O1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Forkhead box O1. Retrieved May 3, 2026, from https://4ort.xyz/entity/forkhead-box-o1

MLA “Forkhead box O1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/forkhead-box-o1.

BibTeX

@misc{4ortxyz_forkhead-box-o1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Forkhead box O1}}, year = {2026}, url = {https://4ort.xyz/entity/forkhead-box-o1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Forkhead box O1 — https://4ort.xyz/entity/forkhead-box-o1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/forkhead-box-o1 · Last refreshed: May 3, 2026