Forkhead box A2

mammalian protein found in Mus musculus

Protein protein Q21983973

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Forkhead box A2

Summary

Forkhead box A2 is a protein^[1].

Key Facts

Forkhead box A2's instance of is recorded as protein^[2].
Forkhead box A2's subclass of is recorded as protein^[3].
Forkhead box A2's UniProt protein ID is recorded as P35583^[4].
Forkhead box A2's part of is recorded as winged helix DNA-binding domain superfamily^[5].
Forkhead box A2's part of is recorded as Winged helix-like DNA-binding domain superfamily^[6].
Forkhead box A2's part of is recorded as Fork-head N-terminal domain, protein family^[7].
Forkhead box A2's part of is recorded as Forkhead box protein, C-terminal domain, protein family^[8].
Forkhead box A2's part of is recorded as Fork head domain, protein family^[9].
Forkhead box A2's part of is recorded as Fork head domain conserved site1, protein family^[10].
Forkhead box A2's part of is recorded as Fork head domain conserved site 2, protein family^[11].
Forkhead box A2's has part is recorded as Fork head domain conserved site 2^[12].
Forkhead box A2's has part is recorded as Fork-head N-terminal^[13].
Forkhead box A2's has part is recorded as Fork head domain conserved site1^[14].
Forkhead box A2's has part is recorded as Fork head domain^[15].
Forkhead box A2's has part is recorded as Forkhead box protein, C-terminal^[16].
Forkhead box A2's RefSeq protein ID is recorded as NP_001277994^[17].
Forkhead box A2's RefSeq protein ID is recorded as NP_001277996^[18].
Forkhead box A2's RefSeq protein ID is recorded as NP_034576^[19].
Forkhead box A2's molecular function is recorded as protein domain specific binding^[20].
Forkhead box A2's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[21].
Forkhead box A2's molecular function is recorded as transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding^[22].
Forkhead box A2's molecular function is recorded as transcription factor binding^[23].
Forkhead box A2's molecular function is recorded as DNA binding^[24].
Forkhead box A2's molecular function is recorded as DNA-binding transcription factor activity^[25].
Forkhead box A2's molecular function is recorded as protein binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of winged helix DNA-binding domain superfamily, Winged helix-like DNA-binding domain superfamily, Fork-head N-terminal domain, protein family, Forkhead box protein, C-terminal domain, protein family, Fork head domain, protein family, Fork head domain conserved site1, protein family, Fork head domain conserved site 2, protein family

Properties

Biological process Notch signaling pathway, anterior/posterior pattern specification, signal transduction involved in regulation of gene expression, regulation of steroid metabolic process, lung epithelial cell differentiation, regulation of insulin secretion involved in cellular response to glucose stimulus, ectoderm formation, transcription, DNA-templated, lung development, primitive streak formation, multicellular organism development, response to interleukin-6, anatomical structure morphogenesis, positive regulation of gastrulation, positive regulation of embryonic development, regulation of gene expression, adult locomotory behavior, negative regulation of glucokinase activity, positive regulation of transcription from RNA polymerase II promoter by glucose, dorsal/ventral pattern formation, regulation of lipid metabolic process, negative regulation of detection of glucose, epithelial tube branching involved in lung morphogenesis, pattern specification process, in utero embryonic development, positive regulation of smoothened signaling pathway, cell development, connective tissue development, negative regulation of neuron differentiation, anatomical structure formation involved in morphogenesis, positive regulation of transcription by RNA polymerase III, cell fate specification, dorsal/ventral neural tube patterning, somite rostral/caudal axis specification, neuron fate specification, cell differentiation in hindbrain, positive regulation of neuron differentiation, transcription by RNA polymerase II, chromatin organization, regulation of transcription by RNA polymerase II, negative regulation of epithelial to mesenchymal transition, regulation of blood coagulation, endocrine pancreas development, negative regulation of DNA-binding transcription factor activity, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, negative regulation of transcription from RNA polymerase II promoter by glucose, dopaminergic neuron differentiation, regulation of transcription, DNA-templated, regulation of transcription by RNA polymerase II, anatomical structure morphogenesis, cell differentiation, mesendoderm development

Cell component cytoplasm, nucleus, nucleoplasm, cell junction, nucleus, transcription regulator complex

Encoded by Foxa2

Found in taxon house mouse

Has part(s) Fork head domain conserved site 2, Fork-head N-terminal, Fork head domain conserved site1, Fork head domain, Forkhead box protein, C-terminal

Imported from wholeness_audit_2026-05-02

Molecular function protein domain specific binding, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, transcription factor binding, DNA binding, DNA-binding transcription factor activity, protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, double-stranded DNA binding, kinase binding, sequence-specific DNA binding, SMAD binding, DNA-binding transcription factor activity, RNA polymerase II-specific, double-stranded DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific

External References (3)

Ensembl protein id ENSMUSP00000134081, ENSMUSP00000045918, ENSMUSP00000105590

Refseq protein id NP_001277994, NP_001277996, NP_034576

Uniprot protein id P35583

🏷️ Also known as

en Forkhead box A2 en forkhead box protein A2 en Foxa2 en hepatocyte nuclear factor 3-beta en hepatocyte nuclear factor 3 beta (winged helix transcription factor) en HNF-3-beta

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Forkhead box A2 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Forkhead box A2 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Forkhead box A2 — UniProt protein ID (P352): P35583. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Forkhead box A2 — part of (P361): winged helix DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Forkhead box A2 — part of (P361): Winged helix-like DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Forkhead box A2 — part of (P361): Fork-head N-terminal domain, protein family. wikidata.org.
[8] ↑ Forkhead box A2 — part of (P361): Forkhead box protein, C-terminal domain, protein family. wikidata.org.
[9] ↑ Forkhead box A2 — part of (P361): Fork head domain, protein family. wikidata.org.
[10] ↑ Forkhead box A2 — part of (P361): Fork head domain conserved site1, protein family. wikidata.org.
[11] ↑ Forkhead box A2 — part of (P361): Fork head domain conserved site 2, protein family. wikidata.org.
[12] ↑ Forkhead box A2 — has part(s) (P527): Fork head domain conserved site 2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Forkhead box A2 — has part(s) (P527): Fork-head N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Forkhead box A2 — has part(s) (P527): Fork head domain conserved site1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Forkhead box A2 — has part(s) (P527): Fork head domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Forkhead box A2 — has part(s) (P527): Forkhead box protein, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Forkhead box A2 — RefSeq protein ID (P637): NP_001277994. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Forkhead box A2 — RefSeq protein ID (P637): NP_001277996. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Forkhead box A2 — RefSeq protein ID (P637): NP_034576. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Forkhead box A2 — molecular function (P680): protein domain specific binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Forkhead box A2 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Forkhead box A2 — molecular function (P680): transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Forkhead box A2 — molecular function (P680): transcription factor binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Forkhead box A2 — molecular function (P680): DNA binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Forkhead box A2 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Forkhead box A2 — molecular function (P680): protein binding. Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Forkhead box A2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Forkhead box A2. Retrieved May 3, 2026, from https://4ort.xyz/entity/forkhead-box-a2-q21983973

MLA

“Forkhead box A2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/forkhead-box-a2-q21983973.

BibTeX

@misc{4ortxyz_forkhead-box-a2-q21983973_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Forkhead box A2}}, year = {2026}, url = {https://4ort.xyz/entity/forkhead-box-a2-q21983973}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Forkhead box A2 — https://4ort.xyz/entity/forkhead-box-a2-q21983973 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/forkhead-box-a2-q21983973 · Last refreshed: May 3, 2026