FMS-like tyrosine kinase 4

mammalian protein found in Mus musculus

Protein protein Q21992684

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FMS-like tyrosine kinase 4

Summary

FMS-like tyrosine kinase 4 is a protein^[1].

Key Facts

FMS-like tyrosine kinase 4's instance of is recorded as protein^[2].
FMS-like tyrosine kinase 4's physically interacts with is recorded as sorafenib^[3].
FMS-like tyrosine kinase 4's UniProt protein ID is recorded as P35917^[4].
FMS-like tyrosine kinase 4's part of is recorded as Immunoglobulin-like fold^[5].
FMS-like tyrosine kinase 4's part of is recorded as vascular endothelial growth factor receptor 3 (VEGFR3)^[6].
FMS-like tyrosine kinase 4's part of is recorded as Immunoglobulin-like domain superfamily^[7].
FMS-like tyrosine kinase 4's part of is recorded as Protein kinase-like domain superfamily^[8].
FMS-like tyrosine kinase 4's part of is recorded as membrane protein^[9].
FMS-like tyrosine kinase 4's part of is recorded as Immunoglobulin I-set, protein family^[10].
FMS-like tyrosine kinase 4's part of is recorded as Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[11].
FMS-like tyrosine kinase 4's part of is recorded as immunoglobulin subtype, protein family^[12].
FMS-like tyrosine kinase 4's part of is recorded as Immunoglobulin subtype 2, protein family^[13].
FMS-like tyrosine kinase 4's part of is recorded as Protein kinase domain, protein family^[14].
FMS-like tyrosine kinase 4's part of is recorded as immunoglobulin-like domain, protein family^[15].
FMS-like tyrosine kinase 4's part of is recorded as Protein kinase, ATP binding site, protein family^[16].
FMS-like tyrosine kinase 4's part of is recorded as Tyrosine-protein kinase, catalytic domain, protein family^[17].
FMS-like tyrosine kinase 4's part of is recorded as Tyrosine-protein kinase, receptor class III, conserved site, protein family^[18].
FMS-like tyrosine kinase 4's part of is recorded as Tyrosine-protein kinase, active site, protein family^[19].
FMS-like tyrosine kinase 4's has part is recorded as immunoglobulin subtype^[20].
FMS-like tyrosine kinase 4's has part is recorded as tyrosine-protein kinase, receptor class III, conserved site^[21].
FMS-like tyrosine kinase 4's has part is recorded as immunoglobulin subtype 2^[22].
FMS-like tyrosine kinase 4's has part is recorded as tyrosine-protein kinase, catalytic domain^[23].
FMS-like tyrosine kinase 4's has part is recorded as tyrosine-protein kinase, active site^[24].
FMS-like tyrosine kinase 4's has part is recorded as serine-threonine/tyrosine-protein kinase, catalytic domain^[25].
FMS-like tyrosine kinase 4's has part is recorded as immunoglobulin-like domain^[26].

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Quick Facts

Instance of protein

Part of Immunoglobulin-like fold, vascular endothelial growth factor receptor 3 (VEGFR3), Immunoglobulin-like domain superfamily, Protein kinase-like domain superfamily, membrane protein, Immunoglobulin I-set, protein family, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, immunoglobulin subtype, protein family, Immunoglobulin subtype 2, protein family, Protein kinase domain, protein family, immunoglobulin-like domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, receptor class III, conserved site, protein family, Tyrosine-protein kinase, active site, protein family

Properties

Biological process regulation of blood vessel remodeling, positive regulation of protein phosphorylation, respiratory system process, positive regulation of endothelial cell proliferation, blood vessel morphogenesis, phosphorylation, lymphangiogenesis, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of protein kinase C signaling, negative regulation of apoptotic process, sprouting angiogenesis, positive regulation of JNK cascade, lymph vessel development, respiratory gaseous exchange by respiratory system, positive regulation of endothelial cell migration, protein phosphorylation, vascular endothelial growth factor receptor signaling pathway, vasculature development, angiogenesis, positive regulation of cell population proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of vascular endothelial growth factor production, peptidyl-tyrosine phosphorylation, cellular response to vascular endothelial growth factor stimulus, lung alveolus development, positive regulation of MAPK cascade, protein autophosphorylation, vascular endothelial growth factor signaling pathway, positive regulation of cell growth, sprouting angiogenesis, negative regulation of signal transduction, cell differentiation, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of cell population proliferation, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of MAPK cascade, vascular endothelial growth factor receptor signaling pathway

Cell component cytoplasm, integral component of membrane, membrane, receptor complex, plasma membrane, integral component of plasma membrane, nucleus, nucleoplasm, cytoplasm, integral component of plasma membrane, receptor complex

Encoded by Flt4

Found in taxon house mouse

Has part(s) immunoglobulin subtype, tyrosine-protein kinase, receptor class III, conserved site, immunoglobulin subtype 2, tyrosine-protein kinase, catalytic domain, tyrosine-protein kinase, active site, serine-threonine/tyrosine-protein kinase, catalytic domain, immunoglobulin-like domain, protein kinase, ATP binding site, immunoglobulin I-set, protein kinase domain

Imported from wholeness_audit_2026-05-02

Molecular function vascular endothelial growth factor-activated receptor activity, transferase activity, nucleotide binding, protein kinase activity, growth factor binding, kinase activity, protein binding, transmembrane receptor protein tyrosine kinase activity, protein tyrosine kinase activity, protein phosphatase binding, ATP binding, protein homodimerization activity, receptor tyrosine kinase, transmembrane signaling receptor activity, vascular endothelial growth factor-activated receptor activity, transmembrane receptor protein tyrosine kinase activity, vascular endothelial growth factor binding

Physically interacts with sorafenib

External References (3)

Ensembl protein id ENSMUSP00000020617

Refseq protein id NP_032055

Uniprot protein id P35917

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ FMS-like tyrosine kinase 4 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ FMS-like tyrosine kinase 4 — physically interacts with (P129): sorafenib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ FMS-like tyrosine kinase 4 — UniProt protein ID (P352): P35917. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ FMS-like tyrosine kinase 4 — part of (P361): Immunoglobulin-like fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ FMS-like tyrosine kinase 4 — part of (P361): vascular endothelial growth factor receptor 3 (VEGFR3). InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ FMS-like tyrosine kinase 4 — part of (P361): Immunoglobulin-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ FMS-like tyrosine kinase 4 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ FMS-like tyrosine kinase 4 — part of (P361): membrane protein. wikidata.org.
[10] ↑ FMS-like tyrosine kinase 4 — part of (P361): Immunoglobulin I-set, protein family. wikidata.org.
[11] ↑ FMS-like tyrosine kinase 4 — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[12] ↑ FMS-like tyrosine kinase 4 — part of (P361): immunoglobulin subtype, protein family. wikidata.org.
[13] ↑ FMS-like tyrosine kinase 4 — part of (P361): Immunoglobulin subtype 2, protein family. wikidata.org.
[14] ↑ FMS-like tyrosine kinase 4 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[15] ↑ FMS-like tyrosine kinase 4 — part of (P361): immunoglobulin-like domain, protein family. wikidata.org.
[16] ↑ FMS-like tyrosine kinase 4 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[17] ↑ FMS-like tyrosine kinase 4 — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[18] ↑ FMS-like tyrosine kinase 4 — part of (P361): Tyrosine-protein kinase, receptor class III, conserved site, protein family. wikidata.org.
[19] ↑ FMS-like tyrosine kinase 4 — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[20] ↑ FMS-like tyrosine kinase 4 — has part(s) (P527): immunoglobulin subtype. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ FMS-like tyrosine kinase 4 — has part(s) (P527): tyrosine-protein kinase, receptor class III, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ FMS-like tyrosine kinase 4 — has part(s) (P527): immunoglobulin subtype 2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ FMS-like tyrosine kinase 4 — has part(s) (P527): tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ FMS-like tyrosine kinase 4 — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ FMS-like tyrosine kinase 4 — has part(s) (P527): serine-threonine/tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ FMS-like tyrosine kinase 4 — has part(s) (P527): immunoglobulin-like domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ FMS-like tyrosine kinase 4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). FMS-like tyrosine kinase 4. Retrieved May 3, 2026, from https://4ort.xyz/entity/fms-like-tyrosine-kinase-4

MLA

“FMS-like tyrosine kinase 4.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/fms-like-tyrosine-kinase-4.

BibTeX

@misc{4ortxyz_fms-like-tyrosine-kinase-4_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{FMS-like tyrosine kinase 4}}, year = {2026}, url = {https://4ort.xyz/entity/fms-like-tyrosine-kinase-4}, note = {Accessed: 2026-05-03}}

LLM prompt

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