fibroblast growth factor receptor 2

mammalian protein found in Homo sapiens

Protein protein Q5446456

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fibroblast growth factor receptor 2

Summary

fibroblast growth factor receptor 2 is a protein^[1].

Key Facts

fibroblast growth factor receptor 2's instance of is recorded as protein^[2].
fibroblast growth factor receptor 2's physically interacts with is recorded as nintedanib^[3].
fibroblast growth factor receptor 2's physically interacts with is recorded as nintedanib^[4].
fibroblast growth factor receptor 2's physically interacts with is recorded as infigratinib^[5].
fibroblast growth factor receptor 2's physically interacts with is recorded as brivanib^[6].
fibroblast growth factor receptor 2's physically interacts with is recorded as erdafitinib^[7].
fibroblast growth factor receptor 2's physically interacts with is recorded as lucitanib^[8].
fibroblast growth factor receptor 2's physically interacts with is recorded as orantinib^[9].
fibroblast growth factor receptor 2 is part of Immunoglobulin-like fold^[10].
fibroblast growth factor receptor 2 is part of Protein kinase-like domain superfamily^[11].
fibroblast growth factor receptor 2 is part of Immunoglobulin-like domain superfamily^[12].
fibroblast growth factor receptor 2 is part of fibroblast growth factor receptor family^[13].
fibroblast growth factor receptor 2 is part of Immunoglobulin I-set, protein family^[14].
fibroblast growth factor receptor 2 is part of Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[15].
fibroblast growth factor receptor 2 is part of immunoglobulin subtype, protein family^[16].
fibroblast growth factor receptor 2 is part of Immunoglobulin subtype 2, protein family^[17].
fibroblast growth factor receptor 2 is part of Protein kinase domain, protein family^[18].
fibroblast growth factor receptor 2 is part of immunoglobulin-like domain, protein family^[19].
fibroblast growth factor receptor 2 is part of Protein kinase, ATP binding site, protein family^[20].
fibroblast growth factor receptor 2 is part of Tyrosine-protein kinase, catalytic domain, protein family^[21].
fibroblast growth factor receptor 2 is part of Tyrosine-protein kinase, active site, protein family^[22].
fibroblast growth factor receptor 2 comprises immunoglobulin-like domain^[23].
fibroblast growth factor receptor 2 comprises tyrosine-protein kinase, catalytic domain^[24].
fibroblast growth factor receptor 2 comprises protein kinase, ATP binding site^[25].
fibroblast growth factor receptor 2 comprises protein kinase domain^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of Immunoglobulin-like fold, Protein kinase-like domain superfamily, Immunoglobulin-like domain superfamily, fibroblast growth factor receptor family, Immunoglobulin I-set, protein family, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, immunoglobulin subtype, protein family, Immunoglobulin subtype 2, protein family, Protein kinase domain, protein family, immunoglobulin-like domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family

Properties

Biological process fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development, ureteric bud development, organ growth, limb bud formation, embryonic pattern specification, bud elongation involved in lung branching, positive regulation of canonical Wnt signaling pathway, membranous septum morphogenesis, fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow, embryonic organ morphogenesis, post-embryonic development, squamous basal epithelial stem cell differentiation involved in prostate gland acinus development, branching morphogenesis of a nerve, reproductive structure development, fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell, ventricular cardiac muscle tissue morphogenesis, protein phosphorylation, positive regulation of cardiac muscle cell proliferation, mesenchymal cell differentiation, positive regulation of mesenchymal cell proliferation, regulation of osteoblast differentiation, prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis, angiogenesis, prostate gland morphogenesis, positive regulation of ERK1 and ERK2 cascade, orbitofrontal cortex development, negative regulation of epithelial cell proliferation, animal organ morphogenesis, embryonic digestive tract morphogenesis, hair follicle morphogenesis, morphogenesis of embryonic epithelium, branch elongation involved in salivary gland morphogenesis, apoptotic process, branching involved in salivary gland morphogenesis, cell fate commitment, lung development, embryonic organ development, fibroblast growth factor receptor signaling pathway involved in hemopoiesis, in utero embryonic development, lateral sprouting from an epithelium, positive regulation of Wnt signaling pathway, gland morphogenesis, positive regulation of cell cycle, branching involved in labyrinthine layer morphogenesis, branching involved in prostate gland morphogenesis, regulation of ERK1 and ERK2 cascade, protein autophosphorylation, mammary gland bud formation, pyramidal neuron development, lacrimal gland development, positive regulation of MAPK cascade, regulation of smooth muscle cell differentiation, regulation of cell fate commitment, bone mineralization, regulation of branching involved in prostate gland morphogenesis, positive regulation of epithelial cell proliferation involved in lung morphogenesis, epithelial cell differentiation, phosphorylation, multicellular organism growth, positive regulation of epithelial cell proliferation, ventricular zone neuroblast division, epidermis morphogenesis, skeletal system morphogenesis, regulation of morphogenesis of a branching structure, negative regulation of transcription by RNA polymerase II, outflow tract septum morphogenesis, odontogenesis, epithelial to mesenchymal transition, lung alveolus development, lung lobe morphogenesis, midbrain development, positive regulation of smooth muscle cell proliferation, fibroblast growth factor receptor signaling pathway involved in mammary gland specification, mesenchymal cell proliferation involved in lung development, prostate epithelial cord elongation, mesenchymal cell differentiation involved in lung development, axonogenesis, regulation of multicellular organism growth, otic vesicle formation, epithelial cell proliferation involved in salivary gland morphogenesis, cell-cell signaling, regulation of fibroblast growth factor receptor signaling pathway, bone morphogenesis, MAPK cascade, regulation of osteoblast proliferation, positive regulation of phospholipase activity, fibroblast growth factor receptor signaling pathway, regulation of smoothened signaling pathway, inner ear morphogenesis, positive regulation of cell population proliferation, mesodermal cell differentiation, peptidyl-tyrosine phosphorylation, digestive tract development, lung-associated mesenchyme development, bone development, positive regulation of cell division, positive regulation of transcription by RNA polymerase II, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, endochondral bone growth, response to lipopolysaccharide, wound healing, cellular response to fibroblast growth factor stimulus, response to ethanol, cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus, embryonic cranial skeleton morphogenesis, positive regulation of protein kinase B signaling, positive regulation of cell population proliferation, negative regulation of signal transduction, cell differentiation, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, transmembrane receptor protein tyrosine kinase signaling pathway

Cell component cytoplasm, membrane, extracellular region, nucleus, cell surface, integral component of membrane, Golgi apparatus, intracellular membrane-bounded organelle, extracellular matrix, plasma membrane, nucleoplasm, cell cortex, integral component of plasma membrane, excitatory synapse, cytoplasmic vesicle, cytoplasm, integral component of plasma membrane, receptor complex, collagen-containing extracellular matrix

Ec enzyme number 2.7.10.1

Encoded by FGFR2

Found in taxon Homo sapiens

Has part(s) immunoglobulin-like domain, tyrosine-protein kinase, catalytic domain, protein kinase, ATP binding site, protein kinase domain, immunoglobulin subtype, immunoglobulin I-set, tyrosine-protein kinase, active site, immunoglobulin subtype 2, serine-threonine/tyrosine-protein kinase, catalytic domain

Molecular function heparin binding, kinase activity, transmembrane receptor protein tyrosine kinase activity, fibroblast growth factor binding, ATP binding, protein kinase activity, fibroblast growth factor-activated receptor activity, transferase activity, protein homodimerization activity, protein binding, nucleotide binding, protein tyrosine kinase activity, 1-phosphatidylinositol-3-kinase activity, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, identical protein binding, receptor tyrosine kinase, transmembrane signaling receptor activity, transmembrane receptor protein tyrosine kinase activity, fibroblast growth factor-activated receptor activity, fibroblast growth factor binding, protein tyrosine kinase activity

Physically interacts with nintedanib, nintedanib, infigratinib, brivanib, erdafitinib, lucitanib, orantinib

External References (6)

Ensembl protein id ENSP00000263451, ENSP00000348559, ENSP00000350166, ENSP00000351276, ENSP00000352309, ENSP00000353262, ENSP00000358052, ENSP00000358054, ENSP00000358056, ENSP00000358057, ENSP00000410294, ENSP00000309878, ENSP00000337665, ENSP00000358055, ENSP00000404219, ENSP00000474011, ENSP00000474109, ENSP00000481464, ENSP00000484154, ENSP00000484892, ENSP00000490905, ENSP00000491912

Mesh descriptor id D051497

Mesh tree code D08.811.913.696.620.682.725.400.178, D12.776.543.750.630.441, D12.776.543.750.750.400.370.750, D12.776.476.568.400.178

Pdb structure id 1DJS, 1E0O, 1EV2, 1GJO, 1II4, 1IIL, 1NUN, 1OEC, 1WVZ, 2FDB, 2PSQ, 2PVF, 2PVY, 2PWL, 2PY3, 2PZ5, 2PZP, 2PZR, 2Q0B, 3B2T, 3CAF, 3CLY, 3CU1, 3DAR, 3EUU, 3OJ2, 3OJM, 3RI1, 4J95, 4J96, 4J97, 4J98, 4J99, 4J23, 4WV1

Refseq protein id NP_000132, NP_001138385, NP_001138386, NP_001138387, NP_001138388, NP_001138389, NP_001138390, NP_001138391, NP_001307583, NP_001307587, NP_075259, NP_075418, XP_006717771, XP_006717773, XP_016871409, XP_016871410, XP_016871413, XP_016871414, XP_024303655, XP_024303656, XP_024303657, XP_024303658, XP_024303659, XP_024303660

Uniprot protein id P21802

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ fibroblast growth factor receptor 2 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ fibroblast growth factor receptor 2 — physically interacts with (P129): nintedanib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ fibroblast growth factor receptor 2 — physically interacts with (P129): nintedanib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[5] ↑ fibroblast growth factor receptor 2 — physically interacts with (P129): infigratinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[6] ↑ fibroblast growth factor receptor 2 — physically interacts with (P129): brivanib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[7] ↑ fibroblast growth factor receptor 2 — physically interacts with (P129): erdafitinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[8] ↑ fibroblast growth factor receptor 2 — physically interacts with (P129): lucitanib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[9] ↑ fibroblast growth factor receptor 2 — physically interacts with (P129): orantinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[10] ↑ fibroblast growth factor receptor 2 — part of (P361): Immunoglobulin-like fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ fibroblast growth factor receptor 2 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ fibroblast growth factor receptor 2 — part of (P361): Immunoglobulin-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ fibroblast growth factor receptor 2 — part of (P361): fibroblast growth factor receptor family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ fibroblast growth factor receptor 2 — part of (P361): Immunoglobulin I-set, protein family. wikidata.org.
[15] ↑ fibroblast growth factor receptor 2 — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[16] ↑ fibroblast growth factor receptor 2 — part of (P361): immunoglobulin subtype, protein family. wikidata.org.
[17] ↑ fibroblast growth factor receptor 2 — part of (P361): Immunoglobulin subtype 2, protein family. wikidata.org.
[18] ↑ fibroblast growth factor receptor 2 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[19] ↑ fibroblast growth factor receptor 2 — part of (P361): immunoglobulin-like domain, protein family. wikidata.org.
[20] ↑ fibroblast growth factor receptor 2 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[21] ↑ fibroblast growth factor receptor 2 — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[22] ↑ fibroblast growth factor receptor 2 — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[23] ↑ fibroblast growth factor receptor 2 — has part(s) (P527): immunoglobulin-like domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ fibroblast growth factor receptor 2 — has part(s) (P527): tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ fibroblast growth factor receptor 2 — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ fibroblast growth factor receptor 2 — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ fibroblast growth factor receptor 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). fibroblast growth factor receptor 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/fibroblast-growth-factor-receptor-2

MLA

“fibroblast growth factor receptor 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/fibroblast-growth-factor-receptor-2.

BibTeX

@misc{4ortxyz_fibroblast-growth-factor-receptor-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{fibroblast growth factor receptor 2}}, year = {2026}, url = {https://4ort.xyz/entity/fibroblast-growth-factor-receptor-2}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): fibroblast growth factor receptor 2 — https://4ort.xyz/entity/fibroblast-growth-factor-receptor-2 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/fibroblast-growth-factor-receptor-2 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

2d ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → P21802

Imported from → —

Mesh descriptor id → D051497

Ensembl protein id → ENSP00000263451, ENSP00000348559, ENSP00000350166 +19

+ 15 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.10.1, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"

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