fibroblast growth factor receptor 1

mammalian protein found in Homo sapiens

Protein protein Q5446453

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fibroblast growth factor receptor 1

Summary

fibroblast growth factor receptor 1 is a protein^[1].

Key Facts

fibroblast growth factor receptor 1's instance of is recorded as protein^[2].
fibroblast growth factor receptor 1's physically interacts with is recorded as nintedanib^[3].
fibroblast growth factor receptor 1's physically interacts with is recorded as pazopanib^[4].
fibroblast growth factor receptor 1's physically interacts with is recorded as sorafenib^[5].
fibroblast growth factor receptor 1's physically interacts with is recorded as sunitinib^[6].
fibroblast growth factor receptor 1 is part of Immunoglobulin-like fold^[7].
fibroblast growth factor receptor 1 is part of Protein kinase-like domain superfamily^[8].
fibroblast growth factor receptor 1 is part of Immunoglobulin-like domain superfamily^[9].
fibroblast growth factor receptor 1 is part of fibroblast growth factor receptor family^[10].
fibroblast growth factor receptor 1 is part of Immunoglobulin I-set, protein family^[11].
fibroblast growth factor receptor 1 is part of Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[12].
fibroblast growth factor receptor 1 is part of immunoglobulin subtype, protein family^[13].
fibroblast growth factor receptor 1 is part of Fibroblast growth factor receptor 1, catalytic domain, protein family^[14].
fibroblast growth factor receptor 1 is part of Immunoglobulin subtype 2, protein family^[15].
fibroblast growth factor receptor 1 is part of Protein kinase domain, protein family^[16].
fibroblast growth factor receptor 1 is part of immunoglobulin-like domain, protein family^[17].
fibroblast growth factor receptor 1 is part of Protein kinase, ATP binding site, protein family^[18].
fibroblast growth factor receptor 1 is part of Tyrosine-protein kinase, catalytic domain, protein family^[19].
fibroblast growth factor receptor 1 is part of Tyrosine-protein kinase, active site, protein family^[20].
fibroblast growth factor receptor 1 is part of Immunoglobulin domain, protein family^[21].
fibroblast growth factor receptor 1 comprises immunoglobulin domain^[22].
fibroblast growth factor receptor 1 comprises tyrosine-protein kinase, active site^[23].
fibroblast growth factor receptor 1 comprises immunoglobulin subtype 2^[24].
fibroblast growth factor receptor 1 comprises protein kinase domain^[25].
fibroblast growth factor receptor 1 comprises immunoglobulin-like domain^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of Immunoglobulin-like fold, Protein kinase-like domain superfamily, Immunoglobulin-like domain superfamily, fibroblast growth factor receptor family, Immunoglobulin I-set, protein family, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, immunoglobulin subtype, protein family, Fibroblast growth factor receptor 1, catalytic domain, protein family, Immunoglobulin subtype 2, protein family, Protein kinase domain, protein family, immunoglobulin-like domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family, Immunoglobulin domain, protein family

Properties

Biological process skeletal system development, ureteric bud development, fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development, positive regulation of endothelial cell chemotaxis to fibroblast growth factor, positive regulation of MAP kinase activity, positive regulation of phospholipase C activity, regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling, positive regulation of cardiac muscle cell proliferation, mesenchymal cell differentiation, positive regulation of mesenchymal cell proliferation, angiogenesis, orbitofrontal cortex development, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, branching involved in salivary gland morphogenesis, regulation of transcription, DNA-templated, blood vessel morphogenesis, regulation of extrinsic apoptotic signaling pathway in absence of ligand, lung development, in utero embryonic development, cell maturation, negative regulation of gene expression, transcription, DNA-templated, positive regulation of cell cycle, embryonic limb morphogenesis, positive regulation of neuron differentiation, protein autophosphorylation, auditory receptor cell development, positive regulation of MAPK cascade, paraxial mesoderm development, chondrocyte differentiation, organ induction, phosphorylation, ventricular zone neuroblast division, skeletal system morphogenesis, neuron migration, outer ear morphogenesis, negative regulation of transcription by RNA polymerase II, middle ear morphogenesis, regulation of gene expression, phosphatidylinositol-mediated signaling, midbrain development, chordate embryonic development, hearing, salivary gland morphogenesis, generation of neurons, MAPK cascade, regulation of lateral mesodermal cell fate specification, positive regulation of phospholipase activity, brain development, regulation of cell population proliferation, inner ear morphogenesis, positive regulation of neuron projection development, regulation of cell differentiation, positive regulation of phosphatidylinositol 3-kinase signaling, peptidyl-tyrosine phosphorylation, lung-associated mesenchyme development, cell migration, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol phosphate biosynthetic process, protein phosphorylation, fibroblast growth factor receptor signaling pathway, positive regulation of cell population proliferation, positive regulation of parathyroid hormone secretion, negative regulation of fibroblast growth factor production, vitamin D3 metabolic process, regulation of phosphorus metabolic process, positive regulation of mitotic cell cycle DNA replication, positive regulation of protein kinase B signaling, regulation of phosphate transport, positive regulation of blood vessel endothelial cell migration, positive regulation of vascular endothelial cell proliferation, ear development, angiogenesis, positive regulation of cell population proliferation, negative regulation of signal transduction, cell differentiation, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, transmembrane receptor protein tyrosine kinase signaling pathway, nervous system development, positive regulation of cell differentiation

Cell component cytoplasm, cytosol, membrane, extracellular region, nucleus, receptor complex, integral component of plasma membrane, cytoplasmic vesicle, plasma membrane, integral component of membrane, nucleolus, cytoplasm, integral component of plasma membrane, receptor complex

Ec enzyme number 2.7.10.1

Encoded by FGFR1

Found in taxon Homo sapiens

Has part(s) immunoglobulin domain, tyrosine-protein kinase, active site, immunoglobulin subtype 2, protein kinase domain, immunoglobulin-like domain, protein kinase, ATP binding site, tyrosine-protein kinase, catalytic domain, serine-threonine/tyrosine-protein kinase, catalytic domain, immunoglobulin I-set, immunoglobulin subtype, Fibroblast growth factor receptor 1, catalytic domain

Molecular function kinase activity, transmembrane receptor protein tyrosine kinase activity, ATP binding, protein kinase activity, transferase activity, protein homodimerization activity, protein binding, nucleotide binding, identical protein binding, fibroblast growth factor binding, fibroblast growth factor-activated receptor activity, heparin binding, 1-phosphatidylinositol-3-kinase activity, protein tyrosine kinase activity, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, receptor-receptor interaction, receptor tyrosine kinase, transmembrane signaling receptor activity, fibroblast growth factor-activated receptor activity, fibroblast growth factor binding, SH2 domain binding, transmembrane receptor protein tyrosine kinase activity, protein tyrosine kinase activity

Physically interacts with nintedanib, pazopanib, sorafenib, sunitinib

External References (7)

Ensembl protein id ENSP00000327229, ENSP00000337247, ENSP00000348537, ENSP00000380280, ENSP00000380297, ENSP00000380302, ENSP00000393312, ENSP00000400162, ENSP00000432972, ENSP00000433163, ENSP00000340636, ENSP00000380292, ENSP00000392645, ENSP00000398318, ENSP00000400708, ENSP00000433569, ENSP00000434473, ENSP00000434712, ENSP00000434800, ENSP00000434869, ENSP00000435254, ENSP00000435283, ENSP00000484553, ENSP00000497266

Mesh descriptor id D051496

Mesh tree code D08.811.913.696.620.682.725.400.177, D12.776.543.750.630.440, D12.776.543.750.750.400.370.500, D12.776.476.568.400.177

Pdb structure id 1AGW, 1CVS, 1EVT, 1FGI, 1FGK, 1FQ9, 1XR0, 2CR3, 2FGI, 3C4F, 3DPK, 3GQI, 3GQL, 3JS2, 3KRJ, 3KRL, 3KXX, 3KY2, 3RHX, 3TT0, 4F63, 4F64, 4F65, 4NK9, 4NKA, 4NKS, 4RWI, 4RWJ, 4RWK, 4RWL, 4UWY, 4WUN, 5AM6, 5AM7, 4ZSA, 5A4C, 4UWB, 4UWC, 5A46, 5FLF, 5EW8, 5B7V

Refseq protein id NP_001167534, NP_001167535, NP_001167536, NP_001167537, NP_001167538, NP_056934, NP_075593, NP_075594, NP_075598, XP_006716366, XP_006716367, XP_006716370, XP_006716373, XP_006716374, XP_006716375, XP_006716377, XP_011542745, XP_011542746, XP_011542747, XP_011542748, XP_011542749, XP_011542750, XP_011542751, XP_011542752, XP_011542753, XP_011542754, XP_016868708, XP_016868709, XP_016868710, XP_016868711, XP_016868713, XP_016868714, XP_016868715, XP_016868716, XP_016868718, XP_016868719, XP_016868720, NP_001341296, NP_001341297, NP_001341298, NP_001341299, XP_024302865

Transporter classification database id 8.A.23.1.7

Uniprot protein id P11362

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ fibroblast growth factor receptor 1 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ fibroblast growth factor receptor 1 — physically interacts with (P129): nintedanib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ fibroblast growth factor receptor 1 — physically interacts with (P129): pazopanib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[5] ↑ fibroblast growth factor receptor 1 — physically interacts with (P129): sorafenib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[6] ↑ fibroblast growth factor receptor 1 — physically interacts with (P129): sunitinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[7] ↑ fibroblast growth factor receptor 1 — part of (P361): Immunoglobulin-like fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ fibroblast growth factor receptor 1 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ fibroblast growth factor receptor 1 — part of (P361): Immunoglobulin-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ fibroblast growth factor receptor 1 — part of (P361): fibroblast growth factor receptor family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ fibroblast growth factor receptor 1 — part of (P361): Immunoglobulin I-set, protein family. wikidata.org.
[12] ↑ fibroblast growth factor receptor 1 — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[13] ↑ fibroblast growth factor receptor 1 — part of (P361): immunoglobulin subtype, protein family. wikidata.org.
[14] ↑ fibroblast growth factor receptor 1 — part of (P361): Fibroblast growth factor receptor 1, catalytic domain, protein family. wikidata.org.
[15] ↑ fibroblast growth factor receptor 1 — part of (P361): Immunoglobulin subtype 2, protein family. wikidata.org.
[16] ↑ fibroblast growth factor receptor 1 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[17] ↑ fibroblast growth factor receptor 1 — part of (P361): immunoglobulin-like domain, protein family. wikidata.org.
[18] ↑ fibroblast growth factor receptor 1 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[19] ↑ fibroblast growth factor receptor 1 — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[20] ↑ fibroblast growth factor receptor 1 — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[21] ↑ fibroblast growth factor receptor 1 — part of (P361): Immunoglobulin domain, protein family. wikidata.org.
[22] ↑ fibroblast growth factor receptor 1 — has part(s) (P527): immunoglobulin domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ fibroblast growth factor receptor 1 — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ fibroblast growth factor receptor 1 — has part(s) (P527): immunoglobulin subtype 2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ fibroblast growth factor receptor 1 — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ fibroblast growth factor receptor 1 — has part(s) (P527): immunoglobulin-like domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ fibroblast growth factor receptor 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). fibroblast growth factor receptor 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/fibroblast-growth-factor-receptor-1-q5446453

MLA

“fibroblast growth factor receptor 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/fibroblast-growth-factor-receptor-1-q5446453.

BibTeX

@misc{4ortxyz_fibroblast-growth-factor-receptor-1-q5446453_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{fibroblast growth factor receptor 1}}, year = {2026}, url = {https://4ort.xyz/entity/fibroblast-growth-factor-receptor-1-q5446453}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): fibroblast growth factor receptor 1 — https://4ort.xyz/entity/fibroblast-growth-factor-receptor-1-q5446453 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/fibroblast-growth-factor-receptor-1-q5446453 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

4w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → P11362

Imported from → —

Mesh descriptor id → D051496

Ensembl protein id → ENSP00000327229, ENSP00000337247, ENSP00000348537 +21

+ 16 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.10.1, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"

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