Fibroblast growth factor 21

mammalian protein found in Homo sapiens
Protein protein Q21172808
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Fibroblast growth factor 21

Summary

Fibroblast growth factor 21 is a protein[1].

Key Facts

  • Fibroblast growth factor 21's image is recorded as FGF21.png[2].
  • Fibroblast growth factor 21's instance of is recorded as protein[3].
  • Fibroblast growth factor 21's subclass of is recorded as protein[4].
  • Fibroblast growth factor 21's UniProt protein ID is recorded as Q9NSA1[5].
  • Fibroblast growth factor 21's part of is recorded as fibroblast growth factor 21[6].
  • Fibroblast growth factor 21's part of is recorded as Cytokine IL1/FGF[7].
  • Fibroblast growth factor 21's RefSeq protein ID is recorded as NP_061986[8].
  • Fibroblast growth factor 21's PDB structure ID is recorded as 5VAQ[9].
  • Fibroblast growth factor 21's PDB structure ID is recorded as 6M6F[10].
  • Fibroblast growth factor 21's PDB structure ID is recorded as 6M6E[11].
  • Fibroblast growth factor 21's molecular function is recorded as growth factor activity[12].
  • Fibroblast growth factor 21's molecular function is recorded as protein binding[13].
  • Fibroblast growth factor 21's molecular function is recorded as fibroblast growth factor receptor binding[14].
  • Fibroblast growth factor 21's cell component is recorded as extracellular region[15].
  • Fibroblast growth factor 21's cell component is recorded as extracellular space[16].
  • Fibroblast growth factor 21's biological process is recorded as endothelial cell apoptotic process[17].
  • Fibroblast growth factor 21's biological process is recorded as positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway[18].
  • Fibroblast growth factor 21's biological process is recorded as positive regulation of ERK1 and ERK2 cascade[19].
  • Fibroblast growth factor 21's biological process is recorded as positive regulation of cell population proliferation[20].
  • Fibroblast growth factor 21's biological process is recorded as positive regulation of glucose import[21].
  • Fibroblast growth factor 21's biological process is recorded as cell-cell signaling[22].
  • Fibroblast growth factor 21's biological process is recorded as cellular response to glucose stimulus[23].
  • Fibroblast growth factor 21's biological process is recorded as fibroblast growth factor receptor signaling pathway[24].
  • Fibroblast growth factor 21's biological process is recorded as regulation of low-density lipoprotein particle clearance[25].
  • Fibroblast growth factor 21's biological process is recorded as response to nutrient levels[26].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] . wikidata.org.
  2. [3] . Q905695. Retrieved . wikidata.org.
  3. [4] . Q905695. Retrieved . wikidata.org.
  4. [5] . Q905695. Retrieved . wikidata.org.
  5. [6] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [7] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [8] . Q20641742. Retrieved . wikidata.org.
  8. [9] . wikidata.org.
  9. [10] . wikidata.org.
  10. [11] . wikidata.org.
  11. [12] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] . C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] . Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] . Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] . Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] . Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] . Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap). Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Fibroblast growth factor 21. Retrieved May 3, 2026, from https://4ort.xyz/entity/fibroblast-growth-factor-21-q21172808
MLA “Fibroblast growth factor 21.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/fibroblast-growth-factor-21-q21172808.
BibTeX @misc{4ortxyz_fibroblast-growth-factor-21-q21172808_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Fibroblast growth factor 21}}, year = {2026}, url = {https://4ort.xyz/entity/fibroblast-growth-factor-21-q21172808}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Fibroblast growth factor 21 — https://4ort.xyz/entity/fibroblast-growth-factor-21-q21172808 (retrieved 2026-05-03)

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