Fas associated via death domain

mammalian protein found in Homo sapiens

Protein protein Q994646

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Summary

Fas associated via death domain is a protein^[1].

Key Facts

Fas associated via death domain's instance of is recorded as protein^[2].
Fas associated via death domain's UniProt protein ID is recorded as strawberry^[3].
Fas associated via death domain's part of is recorded as FADD^[4].
Fas associated via death domain's part of is recorded as Death-like domain superfamily^[5].
Fas associated via death domain's part of is recorded as Death domain, protein family^[6].
Fas associated via death domain's part of is recorded as Death effector domain, protein family^[7].
Fas associated via death domain's has part is recorded as death domain^[8].
Fas associated via death domain's has part is recorded as death effector domain^[9].
Fas associated via death domain's RefSeq protein ID is recorded as NP_003815^[10].
Fas associated via death domain's PDB structure ID is recorded as 3OQ9^[11].
Fas associated via death domain's PDB structure ID is recorded as 1A1W^[12].
Fas associated via death domain's PDB structure ID is recorded as 1A1Z^[13].
Fas associated via death domain's PDB structure ID is recorded as 1E3Y^[14].
Fas associated via death domain's PDB structure ID is recorded as 1E41^[15].
Fas associated via death domain's PDB structure ID is recorded as 2GF5^[16].
Fas associated via death domain's PDB structure ID is recorded as 3EZQ^[17].
Fas associated via death domain's molecular function is recorded as identical protein binding^[18].
Fas associated via death domain's molecular function is recorded as tumor necrosis factor receptor superfamily binding^[19].
Fas associated via death domain's molecular function is recorded as death effector domain binding^[20].
Fas associated via death domain's molecular function is recorded as caspase binding^[21].
Fas associated via death domain's molecular function is recorded as protein binding^[22].
Fas associated via death domain's molecular function is recorded as protease binding^[23].
Fas associated via death domain's molecular function is recorded as death receptor binding^[24].
Fas associated via death domain's molecular function is recorded as tumor necrosis factor receptor binding^[25].
Fas associated via death domain's molecular function is recorded as receptor serine/threonine kinase binding^[26].

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Quick Facts

Instance of protein

Part of FADD, Death-like domain superfamily, Death domain, protein family, Death effector domain, protein family

Properties

Biological process TRAIL-activated apoptotic signaling pathway, regulation of extrinsic apoptotic signaling pathway via death domain receptors, motor neuron apoptotic process, immune system process, necroptotic signaling pathway, activation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of necroptotic process, positive regulation of interleukin-8 production, positive regulation of type I interferon-mediated signaling pathway, cell surface receptor signaling pathway, TRIF-dependent toll-like receptor signaling pathway, positive regulation of macrophage differentiation, defense response to virus, activation of cysteine-type endopeptidase activity, apoptotic signaling pathway, cellular response to mechanical stimulus, extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of transcription by RNA polymerase II, extrinsic apoptotic signaling pathway via death domain receptors, regulation of apoptotic process, death-inducing signaling complex assembly, positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of tumor necrosis factor production, positive regulation of I-kappaB kinase/NF-kappaB signaling, signal transduction, positive regulation of proteolysis, viral process, apoptotic process, positive regulation of activated T cell proliferation, extrinsic apoptotic signaling pathway, positive regulation of T cell mediated cytotoxicity, positive regulation of extrinsic apoptotic signaling pathway, thymus development, positive regulation of adaptive immune response, T cell differentiation in thymus, innate immune response, spleen development, negative regulation of activation-induced cell death of T cells, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of interferon-gamma production, positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation, lymph node development, T cell homeostasis, response to cocaine, response to morphine, behavioral response to cocaine, regulation of necroptotic process, positive regulation of apoptotic process, toll-like receptor 3 signaling pathway, kidney development, TRAIL-activated apoptotic signaling pathway, positive regulation of extrinsic apoptotic signaling pathway

Cell component cytosol, membrane raft, ripoptosome, cell body, neuron projection, CD95 death-inducing signaling complex, plasma membrane, death-inducing signaling complex, cytoplasm, nucleus, protein-containing complex, cytoplasm, CD95 death-inducing signaling complex

Encoded by FADD

Found in taxon Homo sapiens

Has part(s) death domain, death effector domain

Imported from wholeness_audit_2026-05-02

Molecular function identical protein binding, tumor necrosis factor receptor superfamily binding, death effector domain binding, caspase binding, protein binding, protease binding, death receptor binding, tumor necrosis factor receptor binding, receptor serine/threonine kinase binding, protein-containing complex binding, death receptor binding, caspase binding

External References (4)

Ensembl protein id ENSP00000301838

Pdb structure id 3OQ9, 1A1W, 1A1Z, 1E3Y, 1E41, 2GF5, 3EZQ

Refseq protein id NP_003815

Uniprot protein id strawberry

🏷️ Also known as

en FADD en FAS-associated death domain protein en Fas associated via death domain en Fas-associating death domain-containing protein en Fas-associating protein with death domain en Fas (TNFRSF6)-associated via death domain en growth-inhibiting gene 3 protein en mediator of receptor-induced toxicity en Mediator of receptor induced toxicity en Protein FADD

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Fas associated via death domain — instance of (P31): protein. UniProt. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Fas associated via death domain — UniProt protein ID (P352): strawberry. wikidata.org.
[4] ↑ Fas associated via death domain — part of (P361): FADD. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Fas associated via death domain — part of (P361): Death-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Fas associated via death domain — part of (P361): Death domain, protein family. wikidata.org.
[7] ↑ Fas associated via death domain — part of (P361): Death effector domain, protein family. wikidata.org.
[8] ↑ Fas associated via death domain — has part(s) (P527): death domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Fas associated via death domain — has part(s) (P527): death effector domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Fas associated via death domain — RefSeq protein ID (P637): NP_003815. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ Fas associated via death domain — PDB structure ID (P638): 3OQ9. UniProt. Retrieved 2016-06-30. wikidata.org.
[12] ↑ Fas associated via death domain — PDB structure ID (P638): 1A1W. UniProt. Retrieved 2016-06-30. wikidata.org.
[13] ↑ Fas associated via death domain — PDB structure ID (P638): 1A1Z. UniProt. Retrieved 2016-06-30. wikidata.org.
[14] ↑ Fas associated via death domain — PDB structure ID (P638): 1E3Y. UniProt. Retrieved 2016-06-30. wikidata.org.
[15] ↑ Fas associated via death domain — PDB structure ID (P638): 1E41. UniProt. Retrieved 2016-06-30. wikidata.org.
[16] ↑ Fas associated via death domain — PDB structure ID (P638): 2GF5. UniProt. Retrieved 2016-06-30. wikidata.org.
[17] ↑ Fas associated via death domain — PDB structure ID (P638): 3EZQ. UniProt. Retrieved 2016-06-30. wikidata.org.
[18] ↑ Fas associated via death domain — molecular function (P680): identical protein binding. A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Fas associated via death domain — molecular function (P680): tumor necrosis factor receptor superfamily binding. Whole-exome-sequencing-based discovery of human FADD deficiency. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Fas associated via death domain — molecular function (P680): death effector domain binding. Caspase-10 is an initiator caspase in death receptor signaling. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Fas associated via death domain — molecular function (P680): caspase binding. Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Fas associated via death domain — molecular function (P680): protein binding. Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Fas associated via death domain — molecular function (P680): protease binding. Casper is a FADD- and caspase-related inducer of apoptosis. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Fas associated via death domain — molecular function (P680): death receptor binding. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Fas associated via death domain — molecular function (P680): tumor necrosis factor receptor binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Fas associated via death domain — molecular function (P680): receptor serine/threonine kinase binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Fas associated via death domain is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Fas associated via death domain. Retrieved May 3, 2026, from https://4ort.xyz/entity/fas-associated-via-death-domain

MLA

“Fas associated via death domain.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/fas-associated-via-death-domain.

BibTeX

@misc{4ortxyz_fas-associated-via-death-domain_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Fas associated via death domain}}, year = {2026}, url = {https://4ort.xyz/entity/fas-associated-via-death-domain}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Fas associated via death domain — https://4ort.xyz/entity/fas-associated-via-death-domain (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/fas-associated-via-death-domain · Last refreshed: May 3, 2026