Eukaryotic translation initiation factor 4A1

mammalian protein found in Homo sapiens
Protein protein Q21173749
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Summary

Eukaryotic translation initiation factor 4A1 is a protein[1]. It is known by 6 alternative names across languages and contexts.[2]

Key Facts

  • Part of: P-loop containing nucleoside triphosphate hydrolase[3], membrane protein[4], Helicase superfamily 1/2, ATP-binding domain, protein family[5], Helicase, C-terminal domain, protein family[6], DEAD/DEAH box helicase[7], RNA helicase, DEAD-box type, Q motif, protein family[8], ATP-dependent RNA helicase DEAD-box, conserved site, protein family[9]
  • Has part(s): RNA helicase, DEAD-box type, Q motif[10], ATP-dependent RNA helicase DEAD-box, conserved site[11], DEAD/DEAH box helicase domain[12], Helicase superfamily 1/2, ATP-binding domain[13], Helicase, C-terminal[14]
  • Molecular function: nucleotide binding[15], helicase activity[16], translation initiation factor activity[17], translation factor activity, RNA binding[18], protein binding[19], nucleic acid binding[20], RNA cap binding[21], double-stranded RNA binding[22], hydrolase activity[23], ATP binding[24], mRNA binding[25], RNA binding[26]
  • Cell component: cytoplasm[27], cytosol[28], membrane[29], eukaryotic translation initiation factor 4F complex[30], extracellular exosome[31], nucleus[32], extracellular matrix[33]
  • Biological process: nuclear-transcribed mRNA poly(A) tail shortening[34], RNA secondary structure unwinding[35], translational initiation[36], regulation of gene expression[37], viral process[38], protein biosynthesis[39]
  • Encoded by: EIF4A1[40]
  • Found in taxon: Homo sapiens[41]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . wikidata.org.
  3. [5] ↑ . wikidata.org.
  4. [6] ↑ . wikidata.org.
  5. [7] ↑ . wikidata.org.
  6. [8] ↑ . wikidata.org.
  7. [9] ↑ . wikidata.org.
  8. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . Cell stress modulates the function of splicing regulatory protein RBM4 in translation control. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I:C)-mediated TLR3 Activation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . Defining the membrane proteome of NK cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . Characterization of the cloned promoter of the human initiation factor 4AI gene. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [31] ↑ . MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [32] ↑ . Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [33] ↑ . SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [34] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [35] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [37] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [38] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [39] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [40] ↑ . UniProt. Retrieved . wikidata.org.
  39. [41] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Eukaryotic translation initiation factor 4A1. Retrieved May 3, 2026, from https://4ort.xyz/entity/eukaryotic-translation-initiation-factor-4a1-q21173749
MLA “Eukaryotic translation initiation factor 4A1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/eukaryotic-translation-initiation-factor-4a1-q21173749.
BibTeX @misc{4ortxyz_eukaryotic-translation-initiation-factor-4a1-q21173749_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Eukaryotic translation initiation factor 4A1}}, year = {2026}, url = {https://4ort.xyz/entity/eukaryotic-translation-initiation-factor-4a1-q21173749}, note = {Accessed: 2026-05-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 13w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → EIF4A1
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → nucleotide binding, helicase activity, translation initiation factor activity +10
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 3.6.4.13, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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