Estrogen receptor 1

mammalian protein found in Rattus norvegicus

Protein protein Q28561762

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Estrogen receptor 1

Summary

Estrogen receptor 1 is a protein^[1].

Key Facts

Estrogen receptor 1's instance of is recorded as protein^[2].
Estrogen receptor 1's UniProt protein ID is recorded as P06211^[3].
Estrogen receptor 1's part of is recorded as Nuclear hormone receptor-like domain superfamily^[4].
Estrogen receptor 1's part of is recorded as Zinc finger, NHR/GATA-type^[5].
Estrogen receptor 1's part of is recorded as oestrogen receptor^[6].
Estrogen receptor 1's part of is recorded as membrane protein^[7].
Estrogen receptor 1's part of is recorded as Nuclear hormone receptor, ligand-binding domain, protein family^[8].
Estrogen receptor 1's part of is recorded as Oestrogen-type nuclear receptor final C-terminal domain, protein family^[9].
Estrogen receptor 1's part of is recorded as Zinc finger, nuclear hormone receptor-type, protein family^[10].
Estrogen receptor 1's has part is recorded as nuclear hormone receptor-type zinc finger^[11].
Estrogen receptor 1's has part is recorded as Nuclear hormone receptor, ligand-binding domain^[12].
Estrogen receptor 1's has part is recorded as Oestrogen-type nuclear receptor final C-terminal domain^[13].
Estrogen receptor 1's RefSeq protein ID is recorded as NP_036821^[14].
Estrogen receptor 1's RefSeq protein ID is recorded as XP_006227894^[15].
Estrogen receptor 1's RefSeq protein ID is recorded as XP_008756926^[16].
Estrogen receptor 1's RefSeq protein ID is recorded as XP_017444284^[17].
Estrogen receptor 1's RefSeq protein ID is recorded as XP_017444285^[18].
Estrogen receptor 1's RefSeq protein ID is recorded as XP_017444286^[19].
Estrogen receptor 1's RefSeq protein ID is recorded as XP_038956957^[20].
Estrogen receptor 1's RefSeq protein ID is recorded as XP_038956961^[21].
Estrogen receptor 1's RefSeq protein ID is recorded as XP_038956977^[22].
Estrogen receptor 1's RefSeq protein ID is recorded as XP_038956979^[23].
Estrogen receptor 1's molecular function is recorded as transcription coactivator binding^[24].
Estrogen receptor 1's molecular function is recorded as DNA binding^[25].
Estrogen receptor 1's molecular function is recorded as chromatin binding^[26].

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Quick Facts

Instance of protein

Part of Nuclear hormone receptor-like domain superfamily, Zinc finger, NHR/GATA-type, oestrogen receptor, membrane protein, Nuclear hormone receptor, ligand-binding domain, protein family, Oestrogen-type nuclear receptor final C-terminal domain, protein family, Zinc finger, nuclear hormone receptor-type, protein family

Properties

Biological process osteoblast development, regulation of transcription, DNA-templated, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of cytosolic calcium ion concentration, male gonad development, positive regulation of phospholipase C activity, intracellular steroid hormone receptor signaling pathway, response to estradiol, negative regulation of I-kappaB kinase/NF-kappaB signaling, steroid hormone mediated signaling pathway, negative regulation of DNA-binding transcription factor activity, regulation of neuron apoptotic process, positive regulation of nitric oxide biosynthetic process, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, negative regulation of glucose import, decidualization, negative regulation of smooth muscle cell proliferation, positive regulation of epithelial cell proliferation, positive regulation of nitric-oxide synthase activity, positive regulation of DNA-binding transcription factor activity, Sertoli cell development, Sertoli cell proliferation, positive regulation of ERK1 and ERK2 cascade, cellular response to estradiol stimulus, negative regulation of triglyceride metabolic process, negative regulation of neuron death, baculum development

Cell component nucleus, cytoplasm, mitochondrion, Golgi apparatus, plasma membrane, membrane, T-tubule, protein-containing complex, neuron projection, terminal bouton, perikaryon, perinuclear region of cytoplasm

Encoded by Esr1

Found in taxon brown rat

Has part(s) nuclear hormone receptor-type zinc finger, Nuclear hormone receptor, ligand-binding domain, Oestrogen-type nuclear receptor final C-terminal domain

Imported from wholeness_audit_2026-05-02

Molecular function transcription coactivator binding, DNA binding, chromatin binding, DNA-binding transcription factor activity, steroid hormone receptor activity, steroid binding, protein binding, zinc ion binding, lipid binding, enzyme binding, estrogen receptor activity, type 1 metabotropic glutamate receptor binding, phosphatidylinositol 3-kinase regulatory subunit binding, hormone binding, sequence-specific DNA binding, protein-containing complex binding, metal ion binding, promoter-specific chromatin binding

External References (3)

Ensembl protein id ENSRNOP00000026350, ENSRNOP00000070339, ENSRNOP00000071034, ENSRNOP00000071400, ENSRNOP00000071981, ENSRNOP00000072170

Refseq protein id NP_036821, XP_006227894, XP_008756926, XP_017444284, XP_017444285, XP_017444286, XP_038956957, XP_038956961, XP_038956977, XP_038956979

Uniprot protein id P06211

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Estrogen receptor 1 — instance of (P31): protein. Q905695. Retrieved 2021-11-17. wikidata.org.
[3] ↑ Estrogen receptor 1 — UniProt protein ID (P352): P06211. Q905695. Retrieved 2021-11-17. wikidata.org.
[4] ↑ Estrogen receptor 1 — part of (P361): Nuclear hormone receptor-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Estrogen receptor 1 — part of (P361): Zinc finger, NHR/GATA-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Estrogen receptor 1 — part of (P361): oestrogen receptor. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Estrogen receptor 1 — part of (P361): membrane protein. wikidata.org.
[8] ↑ Estrogen receptor 1 — part of (P361): Nuclear hormone receptor, ligand-binding domain, protein family. wikidata.org.
[9] ↑ Estrogen receptor 1 — part of (P361): Oestrogen-type nuclear receptor final C-terminal domain, protein family. wikidata.org.
[10] ↑ Estrogen receptor 1 — part of (P361): Zinc finger, nuclear hormone receptor-type, protein family. wikidata.org.
[11] ↑ Estrogen receptor 1 — has part(s) (P527): nuclear hormone receptor-type zinc finger. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Estrogen receptor 1 — has part(s) (P527): Nuclear hormone receptor, ligand-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Estrogen receptor 1 — has part(s) (P527): Oestrogen-type nuclear receptor final C-terminal domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Estrogen receptor 1 — RefSeq protein ID (P637): NP_036821. Q20641742. Retrieved 2021-09-07. wikidata.org.
[15] ↑ Estrogen receptor 1 — RefSeq protein ID (P637): XP_006227894. Q20641742. Retrieved 2021-09-07. wikidata.org.
[16] ↑ Estrogen receptor 1 — RefSeq protein ID (P637): XP_008756926. Q20641742. Retrieved 2021-09-07. wikidata.org.
[17] ↑ Estrogen receptor 1 — RefSeq protein ID (P637): XP_017444284. Q20641742. Retrieved 2021-09-07. wikidata.org.
[18] ↑ Estrogen receptor 1 — RefSeq protein ID (P637): XP_017444285. Q20641742. Retrieved 2021-09-07. wikidata.org.
[19] ↑ Estrogen receptor 1 — RefSeq protein ID (P637): XP_017444286. Q20641742. Retrieved 2021-09-07. wikidata.org.
[20] ↑ Estrogen receptor 1 — RefSeq protein ID (P637): XP_038956957. Q20641742. Retrieved 2021-09-07. wikidata.org.
[21] ↑ Estrogen receptor 1 — RefSeq protein ID (P637): XP_038956961. Q20641742. Retrieved 2021-09-07. wikidata.org.
[22] ↑ Estrogen receptor 1 — RefSeq protein ID (P637): XP_038956977. Q20641742. Retrieved 2021-09-07. wikidata.org.
[23] ↑ Estrogen receptor 1 — RefSeq protein ID (P637): XP_038956979. Q20641742. Retrieved 2021-09-07. wikidata.org.
[24] ↑ Estrogen receptor 1 — molecular function (P680): transcription coactivator binding. Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Estrogen receptor 1 — molecular function (P680): DNA binding. Isoform specificity for oestrogen receptor and thyroid hormone receptor genes and their interactions on the NR2D gene promoter. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Estrogen receptor 1 — molecular function (P680): chromatin binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Estrogen receptor 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Estrogen receptor 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/estrogen-receptor-1-q28561762

MLA

“Estrogen receptor 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/estrogen-receptor-1-q28561762.

BibTeX

@misc{4ortxyz_estrogen-receptor-1-q28561762_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Estrogen receptor 1}}, year = {2026}, url = {https://4ort.xyz/entity/estrogen-receptor-1-q28561762}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Estrogen receptor 1 — https://4ort.xyz/entity/estrogen-receptor-1-q28561762 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/estrogen-receptor-1-q28561762 · Last refreshed: May 3, 2026