Estrogen receptor 1 (alpha)

mammalian protein found in Mus musculus

Protein protein Q14902317

Press Enter · cited answer in seconds

Estrogen receptor 1 (alpha)

Summary

Estrogen receptor 1 (alpha) is a protein^[1].

Key Facts

Estrogen receptor 1 (alpha)'s instance of is recorded as protein^[2].
Estrogen receptor 1 (alpha)'s UniProt protein ID is recorded as P19785^[3].
Estrogen receptor 1 (alpha)'s part of is recorded as Nuclear hormone receptor-like domain superfamily^[4].
Estrogen receptor 1 (alpha)'s part of is recorded as Zinc finger, NHR/GATA-type^[5].
Estrogen receptor 1 (alpha)'s part of is recorded as oestrogen receptor^[6].
Estrogen receptor 1 (alpha)'s part of is recorded as membrane protein^[7].
Estrogen receptor 1 (alpha)'s part of is recorded as Nuclear hormone receptor, ligand-binding domain, protein family^[8].
Estrogen receptor 1 (alpha)'s part of is recorded as Oestrogen-type nuclear receptor final C-terminal domain, protein family^[9].
Estrogen receptor 1 (alpha)'s part of is recorded as Zinc finger, nuclear hormone receptor-type, protein family^[10].
Estrogen receptor 1 (alpha)'s has part is recorded as Oestrogen-type nuclear receptor final C-terminal domain^[11].
Estrogen receptor 1 (alpha)'s has part is recorded as Nuclear hormone receptor, ligand-binding domain^[12].
Estrogen receptor 1 (alpha)'s has part is recorded as nuclear hormone receptor-type zinc finger^[13].
Estrogen receptor 1 (alpha)'s RefSeq protein ID is recorded as NP_001289460^[14].
Estrogen receptor 1 (alpha)'s RefSeq protein ID is recorded as NP_001289461^[15].
Estrogen receptor 1 (alpha)'s RefSeq protein ID is recorded as NP_001289462^[16].
Estrogen receptor 1 (alpha)'s RefSeq protein ID is recorded as NP_031982^[17].
Estrogen receptor 1 (alpha)'s RefSeq protein ID is recorded as XP_006512496^[18].
Estrogen receptor 1 (alpha)'s RefSeq protein ID is recorded as XP_006512497^[19].
Estrogen receptor 1 (alpha)'s RefSeq protein ID is recorded as XP_006512498^[20].
Estrogen receptor 1 (alpha)'s RefSeq protein ID is recorded as XP_011241368^[21].
Estrogen receptor 1 (alpha)'s RefSeq protein ID is recorded as XP_011241370^[22].
Estrogen receptor 1 (alpha)'s RefSeq protein ID is recorded as XP_036011483^[23].
Estrogen receptor 1 (alpha)'s molecular function is recorded as chromatin binding^[24].
Estrogen receptor 1 (alpha)'s molecular function is recorded as metal ion binding^[25].
Estrogen receptor 1 (alpha)'s molecular function is recorded as estrogen response element binding^[26].

⭐ Popularity Graph

0/100 long tail

📊 Google Search Volume

no search data yet

Quick Facts

Instance of protein

Part of Nuclear hormone receptor-like domain superfamily, Zinc finger, NHR/GATA-type, oestrogen receptor, membrane protein, Nuclear hormone receptor, ligand-binding domain, protein family, Oestrogen-type nuclear receptor final C-terminal domain, protein family, Zinc finger, nuclear hormone receptor-type, protein family

Properties

Biological process regulation of branching involved in prostate gland morphogenesis, steroid hormone mediated signaling pathway, negative regulation of I-kappaB kinase/NF-kappaB signaling, mammary gland alveolus development, regulation of inflammatory response, cell growth, regulation of transcription, DNA-templated, transcription by RNA polymerase II, negative regulation of DNA-binding transcription factor activity, positive regulation of fibroblast proliferation, uterus development, androgen metabolic process, mammary gland branching involved in pregnancy, regulation of toll-like receptor signaling pathway, negative regulation of mitotic nuclear division, vagina development, epithelial cell proliferation involved in mammary gland duct elongation, prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis, antral ovarian follicle growth, transcription, DNA-templated, negative regulation of gene expression, prostate epithelial cord elongation, response to estradiol, response to estrogen, cellular response to estrogen stimulus, positive regulation of transcription, DNA-templated, positive regulation of DNA-binding transcription factor activity, positive regulation of transcription by RNA polymerase II, epithelial cell development, regulation of apoptotic process, protein localization to chromatin, male gonad development, negative regulation of production of miRNAs involved in gene silencing by miRNA, negative regulation of transcription by RNA polymerase II, positive regulation of nitric oxide biosynthetic process, positive regulation of nitric-oxide synthase activity, cellular response to estradiol stimulus, intracellular estrogen receptor signaling pathway, positive regulation of RNA polymerase II transcription preinitiation complex assembly, stem cell differentiation, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of cytosolic calcium ion concentration, positive regulation of phospholipase C activity, intracellular steroid hormone receptor signaling pathway, regulation of neuron apoptotic process, positive regulation of epidermal growth factor receptor signaling pathway, negative regulation of glucose import, negative regulation of smooth muscle cell proliferation, positive regulation of epithelial cell proliferation, Sertoli cell proliferation, positive regulation of ERK1 and ERK2 cascade, negative regulation of triglyceride metabolic process, negative regulation of neuron death

Cell component nucleus, cytoplasm, plasma membrane, Golgi apparatus, membrane, transcription preinitiation complex, protein-containing complex, mitochondrion, T-tubule, neuron projection, terminal bouton, perikaryon, perinuclear region of cytoplasm

Encoded by Esr1

Found in taxon house mouse

Has part(s) Oestrogen-type nuclear receptor final C-terminal domain, Nuclear hormone receptor, ligand-binding domain, nuclear hormone receptor-type zinc finger

Imported from wholeness_audit_2026-05-02

Molecular function chromatin binding, metal ion binding, estrogen response element binding, DNA-binding transcription factor activity, identical protein binding, beta-catenin binding, nuclear receptor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, ATPase binding, core promoter sequence-specific DNA binding, enzyme binding, protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, lipid binding, zinc ion binding, transcription factor binding, protein kinase binding, sequence-specific DNA binding, TFIIB-class transcription factor binding, TBP-class protein binding, estrogen receptor activity, estrogen receptor binding, transcription coactivator binding, DNA binding, steroid hormone receptor activity, steroid binding, type 1 metabotropic glutamate receptor binding, phosphatidylinositol 3-kinase regulatory subunit binding, hormone binding, protein-containing complex binding, promoter-specific chromatin binding, nuclear receptor activity, nuclear receptor activity

External References (3)

Ensembl protein id ENSMUSP00000070070, ENSMUSP00000101214, ENSMUSP00000101215, ENSMUSP00000101213

Refseq protein id NP_001289460, NP_001289461, NP_001289462, NP_031982, XP_006512496, XP_006512497, XP_006512498, XP_011241368, XP_011241370, XP_036011483

Uniprot protein id P19785

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Estrogen receptor 1 (alpha) — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Estrogen receptor 1 (alpha) — UniProt protein ID (P352): P19785. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Estrogen receptor 1 (alpha) — part of (P361): Nuclear hormone receptor-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Estrogen receptor 1 (alpha) — part of (P361): Zinc finger, NHR/GATA-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Estrogen receptor 1 (alpha) — part of (P361): oestrogen receptor. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Estrogen receptor 1 (alpha) — part of (P361): membrane protein. wikidata.org.
[8] ↑ Estrogen receptor 1 (alpha) — part of (P361): Nuclear hormone receptor, ligand-binding domain, protein family. wikidata.org.
[9] ↑ Estrogen receptor 1 (alpha) — part of (P361): Oestrogen-type nuclear receptor final C-terminal domain, protein family. wikidata.org.
[10] ↑ Estrogen receptor 1 (alpha) — part of (P361): Zinc finger, nuclear hormone receptor-type, protein family. wikidata.org.
[11] ↑ Estrogen receptor 1 (alpha) — has part(s) (P527): Oestrogen-type nuclear receptor final C-terminal domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Estrogen receptor 1 (alpha) — has part(s) (P527): Nuclear hormone receptor, ligand-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Estrogen receptor 1 (alpha) — has part(s) (P527): nuclear hormone receptor-type zinc finger. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Estrogen receptor 1 (alpha) — RefSeq protein ID (P637): NP_001289460. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Estrogen receptor 1 (alpha) — RefSeq protein ID (P637): NP_001289461. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Estrogen receptor 1 (alpha) — RefSeq protein ID (P637): NP_001289462. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Estrogen receptor 1 (alpha) — RefSeq protein ID (P637): NP_031982. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Estrogen receptor 1 (alpha) — RefSeq protein ID (P637): XP_006512496. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Estrogen receptor 1 (alpha) — RefSeq protein ID (P637): XP_006512497. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Estrogen receptor 1 (alpha) — RefSeq protein ID (P637): XP_006512498. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Estrogen receptor 1 (alpha) — RefSeq protein ID (P637): XP_011241368. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ Estrogen receptor 1 (alpha) — RefSeq protein ID (P637): XP_011241370. Q20641742. Retrieved 2022-03-20. wikidata.org.
[23] ↑ Estrogen receptor 1 (alpha) — RefSeq protein ID (P637): XP_036011483. Q20641742. Retrieved 2022-03-20. wikidata.org.
[24] ↑ Estrogen receptor 1 (alpha) — molecular function (P680): chromatin binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Estrogen receptor 1 (alpha) — molecular function (P680): metal ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Estrogen receptor 1 (alpha) — molecular function (P680): estrogen response element binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Estrogen receptor 1 (alpha) is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Estrogen receptor 1 (alpha). Retrieved May 3, 2026, from https://4ort.xyz/entity/estrogen-receptor-1-alpha-

MLA

“Estrogen receptor 1 (alpha).” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/estrogen-receptor-1-alpha-.

BibTeX

@misc{4ortxyz_estrogen-receptor-1-alpha-_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Estrogen receptor 1 (alpha)}}, year = {2026}, url = {https://4ort.xyz/entity/estrogen-receptor-1-alpha-}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Estrogen receptor 1 (alpha) — https://4ort.xyz/entity/estrogen-receptor-1-alpha- (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/estrogen-receptor-1-alpha- · Last refreshed: May 3, 2026