Erb-b2 receptor tyrosine kinase 4

mammalian protein found in Homo sapiens

Protein protein Q21104817

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Erb-b2 receptor tyrosine kinase 4

Summary

Erb-b2 receptor tyrosine kinase 4 is a protein^[1].

Key Facts

Erb-b2 receptor tyrosine kinase 4's instance of is recorded as protein^[2].
Erb-b2 receptor tyrosine kinase 4's physically interacts with is recorded as dacomitinib^[3].
Erb-b2 receptor tyrosine kinase 4 is part of Protein kinase-like domain superfamily^[4].
Erb-b2 receptor tyrosine kinase 4 is part of Tyrosine protein kinase, EGF/ERB/XmrK receptor^[5].
Erb-b2 receptor tyrosine kinase 4 is part of Growth factor receptor cysteine-rich domain superfamily^[6].
Erb-b2 receptor tyrosine kinase 4 is part of Receptor L-domain superfamily^[7].
Erb-b2 receptor tyrosine kinase 4 is part of Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[8].
Erb-b2 receptor tyrosine kinase 4 is part of Growth factor receptor domain 4, protein family^[9].
Erb-b2 receptor tyrosine kinase 4 is part of Receptor L-domain, protein family^[10].
Erb-b2 receptor tyrosine kinase 4 is part of Furin-like cysteine-rich domain, protein family^[11].
Erb-b2 receptor tyrosine kinase 4 is part of Protein kinase domain, protein family^[12].
Erb-b2 receptor tyrosine kinase 4 is part of Protein kinase, ATP binding site, protein family^[13].
Erb-b2 receptor tyrosine kinase 4 is part of Tyrosine-protein kinase, catalytic domain, protein family^[14].
Erb-b2 receptor tyrosine kinase 4 is part of Tyrosine-protein kinase, active site, protein family^[15].
Erb-b2 receptor tyrosine kinase 4 is part of Furin-like repeat, protein family^[16].
Erb-b2 receptor tyrosine kinase 4 comprises tyrosine-protein kinase, active site^[17].
Erb-b2 receptor tyrosine kinase 4 comprises protein kinase, ATP binding site^[18].
Erb-b2 receptor tyrosine kinase 4 comprises protein kinase domain^[19].
Erb-b2 receptor tyrosine kinase 4 comprises tyrosine-protein kinase, catalytic domain^[20].
Erb-b2 receptor tyrosine kinase 4 comprises Growth factor receptor domain 4^[21].
Erb-b2 receptor tyrosine kinase 4 comprises Receptor L-domain^[22].
Erb-b2 receptor tyrosine kinase 4 comprises serine-threonine/tyrosine-protein kinase, catalytic domain^[23].
Erb-b2 receptor tyrosine kinase 4 comprises Furin-like repeat^[24].
Erb-b2 receptor tyrosine kinase 4 comprises Furin-like cysteine-rich domain^[25].
Erb-b2 receptor tyrosine kinase 4's molecular function is recorded as transferase activity^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of Protein kinase-like domain superfamily, Tyrosine protein kinase, EGF/ERB/XmrK receptor, Growth factor receptor cysteine-rich domain superfamily, Receptor L-domain superfamily, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, Growth factor receptor domain 4, protein family, Receptor L-domain, protein family, Furin-like cysteine-rich domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family, Furin-like repeat, protein family

Properties

Biological process mitochondrial fragmentation involved in apoptotic process, negative regulation of neuron migration, cell fate commitment, positive regulation of protein phosphorylation, regulation of cell migration, regulation of transcription, DNA-templated, olfactory bulb interneuron differentiation, embryonic pattern specification, phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, central nervous system morphogenesis, mammary gland alveolus development, transcription, DNA-templated, nervous system development, mammary gland epithelial cell differentiation, MAPK cascade, positive regulation of phosphatidylinositol 3-kinase activity, positive regulation of transcription, DNA-templated, multicellular organism development, development of the heart, protein phosphorylation, positive regulation of cardiac muscle cell proliferation, neural crest cell migration, positive regulation of ERK1 and ERK2 cascade, positive regulation of protein localization to cell surface, protein autophosphorylation, cardiac muscle tissue regeneration, positive regulation of phosphatidylinositol 3-kinase signaling, peptidyl-tyrosine phosphorylation, lactation, cell population proliferation, cell migration, signal transduction, negative regulation of cell population proliferation, apoptotic process, ERBB2 signaling pathway, phosphatidylinositol phosphate biosynthetic process, peptidyl-tyrosine autophosphorylation, positive regulation of cell population proliferation, positive regulation of apoptotic process, regulation of cell motility, negative regulation of apoptotic process, cellular response to epidermal growth factor stimulus, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of protein kinase B signaling, positive regulation of receptor signaling pathway via JAK-STAT, synapse assembly, negative regulation of apoptotic process, positive regulation of cell population proliferation, negative regulation of signal transduction, cell differentiation, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of cell population proliferation

Cell component integral component of membrane, cytosol, membrane, receptor complex, plasma membrane, nucleoplasm, extracellular region, mitochondrial matrix, basolateral plasma membrane, mitochondrion, nucleus, postsynaptic membrane, glutamatergic synapse, GABA-ergic synapse, integral component of presynaptic membrane, integral component of postsynaptic density membrane, cytoplasm, integral component of plasma membrane, basal plasma membrane, receptor complex

Ec enzyme number 2.7.10.1

Encoded by ERBB4

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon Homo sapiens

Has part(s) tyrosine-protein kinase, active site, protein kinase, ATP binding site, protein kinase domain, tyrosine-protein kinase, catalytic domain, Growth factor receptor domain 4, Receptor L-domain, serine-threonine/tyrosine-protein kinase, catalytic domain, Furin-like repeat, Furin-like cysteine-rich domain

Molecular function transferase activity, nucleotide binding, protein kinase activity, protein homodimerization activity, epidermal growth factor receptor binding, kinase activity, protein binding, transmembrane receptor protein tyrosine kinase activity, ATP binding, protein tyrosine kinase activity, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, receptor tyrosine kinase, transmembrane signaling receptor activity, epidermal growth factor receptor binding, transmembrane receptor protein tyrosine kinase activity, protein tyrosine kinase activity

Physically interacts with dacomitinib

External References (8)

Ensembl protein id ENSP00000342235, ENSP00000403204, ENSP00000260943, ENSP00000385565, ENSP00000405564

Mesh descriptor id D066247

Mesh tree code D08.811.913.696.620.682.725.400.009.600, D12.776.543.750.630.009.600, D12.776.543.750.750.400.074.600, D12.776.624.664.700.791, D23.101.140.760, D12.776.476.568.400.009.600

Pdb structure id 2AHX, 2L2T, 2LCX, 2R4B, 3BBT, 3BBW, 3BCE, 3U2P, 3U7U, 3U9U

Refseq protein id NP_001036064, NP_005226, XP_005246433, XP_005246434, XP_006712427, XP_016859066, XP_016859067, XP_016859068, XP_016859069, XP_016859070, XP_016859071

Transporter classification database id 8.A.23.1.17

Umls cui C0214098

Uniprot protein id Tweralpspitz

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Erb-b2 receptor tyrosine kinase 4 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Erb-b2 receptor tyrosine kinase 4 — physically interacts with (P129): dacomitinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ Erb-b2 receptor tyrosine kinase 4 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Erb-b2 receptor tyrosine kinase 4 — part of (P361): Tyrosine protein kinase, EGF/ERB/XmrK receptor. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Erb-b2 receptor tyrosine kinase 4 — part of (P361): Growth factor receptor cysteine-rich domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Erb-b2 receptor tyrosine kinase 4 — part of (P361): Receptor L-domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Erb-b2 receptor tyrosine kinase 4 — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[9] ↑ Erb-b2 receptor tyrosine kinase 4 — part of (P361): Growth factor receptor domain 4, protein family. wikidata.org.
[10] ↑ Erb-b2 receptor tyrosine kinase 4 — part of (P361): Receptor L-domain, protein family. wikidata.org.
[11] ↑ Erb-b2 receptor tyrosine kinase 4 — part of (P361): Furin-like cysteine-rich domain, protein family. wikidata.org.
[12] ↑ Erb-b2 receptor tyrosine kinase 4 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[13] ↑ Erb-b2 receptor tyrosine kinase 4 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[14] ↑ Erb-b2 receptor tyrosine kinase 4 — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[15] ↑ Erb-b2 receptor tyrosine kinase 4 — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[16] ↑ Erb-b2 receptor tyrosine kinase 4 — part of (P361): Furin-like repeat, protein family. wikidata.org.
[17] ↑ Erb-b2 receptor tyrosine kinase 4 — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Erb-b2 receptor tyrosine kinase 4 — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Erb-b2 receptor tyrosine kinase 4 — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Erb-b2 receptor tyrosine kinase 4 — has part(s) (P527): tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Erb-b2 receptor tyrosine kinase 4 — has part(s) (P527): Growth factor receptor domain 4. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Erb-b2 receptor tyrosine kinase 4 — has part(s) (P527): Receptor L-domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Erb-b2 receptor tyrosine kinase 4 — has part(s) (P527): serine-threonine/tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Erb-b2 receptor tyrosine kinase 4 — has part(s) (P527): Furin-like repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Erb-b2 receptor tyrosine kinase 4 — has part(s) (P527): Furin-like cysteine-rich domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Erb-b2 receptor tyrosine kinase 4 — molecular function (P680): transferase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Erb-b2 receptor tyrosine kinase 4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“Erb-b2 receptor tyrosine kinase 4.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/erb-b2-receptor-tyrosine-kinase-4.

BibTeX

@misc{4ortxyz_erb-b2-receptor-tyrosine-kinase-4_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Erb-b2 receptor tyrosine kinase 4}}, year = {2026}, url = {https://4ort.xyz/entity/erb-b2-receptor-tyrosine-kinase-4}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Erb-b2 receptor tyrosine kinase 4 — https://4ort.xyz/entity/erb-b2-receptor-tyrosine-kinase-4 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/erb-b2-receptor-tyrosine-kinase-4 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

4w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Found in taxon → Homo sapiens

Physically interacts with → dacomitinib

Wikidata description → mammalian protein found in Homo sapiens

Mesh tree code → D08.811.913.696.620.682.725.400.009.600, D12.776.543.750.630.009.600, D12.776.543.750.750.400.074.600 +3

+ 17 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.10.1, [[:toollabs:quickstatements/#/batch/261489|batch #261489]]"

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