Epidermal growth factor receptor

mammalian protein found in Mus musculus

Protein protein Q21981692

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Summary

Epidermal growth factor receptor is a protein^[1]. It is known by 4 alternative names across languages and contexts.^[2]

Key Facts

Epidermal growth factor receptor's instance of is recorded as protein^[3].
Epidermal growth factor receptor is part of Protein kinase-like domain superfamily^[4].
Epidermal growth factor receptor is part of Tyrosine protein kinase, EGF/ERB/XmrK receptor^[5].
Epidermal growth factor receptor is part of Growth factor receptor cysteine-rich domain superfamily^[6].
Epidermal growth factor receptor is part of Receptor L-domain superfamily^[7].
Epidermal growth factor receptor is part of membrane protein^[8].
Epidermal growth factor receptor is part of Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[9].
Epidermal growth factor receptor is part of Growth factor receptor domain 4, protein family^[10].
Epidermal growth factor receptor is part of Receptor L-domain, protein family^[11].
Epidermal growth factor receptor is part of Furin-like cysteine-rich domain, protein family^[12].
Epidermal growth factor receptor is part of Protein kinase domain, protein family^[13].
Epidermal growth factor receptor is part of Protein kinase, ATP binding site, protein family^[14].
Epidermal growth factor receptor is part of Tyrosine-protein kinase, catalytic domain, protein family^[15].
Epidermal growth factor receptor is part of Tyrosine-protein kinase, active site, protein family^[16].
Epidermal growth factor receptor is part of Furin-like repeat, protein family^[17].
Epidermal growth factor receptor comprises Furin-like repeat^[18].
Epidermal growth factor receptor comprises tyrosine-protein kinase, active site^[19].
Epidermal growth factor receptor comprises tyrosine-protein kinase, catalytic domain^[20].
Epidermal growth factor receptor comprises serine-threonine/tyrosine-protein kinase, catalytic domain^[21].
Epidermal growth factor receptor comprises Receptor L-domain^[22].
Epidermal growth factor receptor comprises Growth factor receptor domain 4^[23].
Epidermal growth factor receptor comprises protein kinase, ATP binding site^[24].
Epidermal growth factor receptor comprises Furin-like cysteine-rich domain^[25].
Epidermal growth factor receptor comprises protein kinase domain^[26].
Epidermal growth factor receptor's molecular function is recorded as kinase activity^[27].

Why It Matters

Epidermal growth factor receptor is known by 4 alternative names across languages and contexts.^[2]

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of Protein kinase-like domain superfamily, Tyrosine protein kinase, EGF/ERB/XmrK receptor, Growth factor receptor cysteine-rich domain superfamily, Receptor L-domain superfamily, membrane protein, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, Growth factor receptor domain 4, protein family, Receptor L-domain, protein family, Furin-like cysteine-rich domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family, Furin-like repeat, protein family

Properties

Biological process positive regulation of protein phosphorylation, positive regulation of MAP kinase activity, protein phosphorylation, cell surface receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, cell population proliferation, morphogenesis of an epithelial fold, positive regulation of protein kinase B signaling, epidermal growth factor receptor signaling pathway, negative regulation of protein catabolic process, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of fibroblast proliferation, epidermis development, protein autophosphorylation, positive regulation of phosphorylation, cerebral cortex cell migration, digestive tract morphogenesis, phosphorylation, positive regulation of epithelial cell proliferation, embryonic placenta development, negative regulation of apoptotic process, eyelid development in camera-type eye, positive regulation of DNA replication, response to UV-A, regulation of peptidyl-tyrosine phosphorylation, positive regulation of cell migration, cellular response to estradiol stimulus, positive regulation of DNA repair, regulation of nitric-oxide synthase activity, salivary gland morphogenesis, multicellular organism development, regulation of cell population proliferation, cell morphogenesis, positive regulation of cell population proliferation, cellular response to amino acid stimulus, signal transduction, positive regulation of transcription by RNA polymerase II, liver development, hair follicle development, positive regulation of cell growth, cellular response to dexamethasone stimulus, response to oxidative stress, hydrogen peroxide metabolic process, circadian rhythm, liver regeneration, response to estradiol, cellular response to mechanical stimulus, response to osmotic stress, response to organic cyclic compound, tongue development, diterpenoid metabolic process, response to lipid, lung development, midgut development, response to cobalamin, response to hydroxyisoflavone, positive regulation of production of miRNAs involved in gene silencing by miRNA, receptor-mediated endocytosis, peptidyl-tyrosine phosphorylation, cellular response to growth factor stimulus, positive regulation of protein kinase C activity, positive regulation of protein localization to plasma membrane, negative regulation of cardiocyte differentiation, regulation of phosphatidylinositol 3-kinase signaling, cellular response to reactive oxygen species, positive regulation of transcription, DNA-templated, regulation of JNK cascade, regulation of ERK1 and ERK2 cascade, cellular response to cadmium ion, positive regulation of NIK/NF-kappaB signaling, positive regulation of peptidyl-serine phosphorylation, peptidyl-tyrosine autophosphorylation, cell-cell adhesion, positive regulation of nitric oxide mediated signal transduction, positive regulation of canonical Wnt signaling pathway, protein biosynthesis, learning or memory, magnesium ion homeostasis, positive regulation of superoxide anion generation, intracellular signal transduction, wound healing, ovarian cycle, positive regulation of bone resorption, positive regulation of vasoconstriction, negative regulation of mitotic cell cycle, astrocyte activation, positive regulation of smooth muscle cell proliferation, neuron projection morphogenesis, positive regulation of inflammatory response, response to calcium ion, positive regulation of synaptic transmission, glutamatergic, cellular response to epidermal growth factor stimulus, positive regulation of prolactin secretion, negative regulation of signal transduction, cell differentiation, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of cell population proliferation, positive regulation of cyclin-dependent protein serine/threonine kinase activity, positive regulation of epithelial cell proliferation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of protein localization to early endosome, positive regulation of cyclin-dependent protein serine/threonine kinase activity, positive regulation of G1/S transition of mitotic cell cycle

Cell component cytoplasm, endosome, multivesicular body, internal vesicle lumen, nuclear membrane, membrane, perinuclear region of cytoplasm, nucleus, cell surface, endoplasmic reticulum, membrane raft, integral component of membrane, Golgi apparatus, early endosome membrane, receptor complex, plasma membrane, intracellular anatomical structure, endosome membrane, endoplasmic reticulum membrane, Golgi membrane, basolateral plasma membrane, protein-containing complex, apical plasma membrane, endocytic vesicle, synapse, cytoplasm, integral component of plasma membrane, basal plasma membrane, receptor complex

Encoded by Egfr

Found in taxon house mouse

Has part(s) Furin-like repeat, tyrosine-protein kinase, active site, tyrosine-protein kinase, catalytic domain, serine-threonine/tyrosine-protein kinase, catalytic domain, Receptor L-domain, Growth factor receptor domain 4, protein kinase, ATP binding site, Furin-like cysteine-rich domain, protein kinase domain

Molecular function kinase activity, nitric-oxide synthase regulator activity, transmembrane receptor protein tyrosine kinase activity, protein phosphatase binding, ATP binding, protein kinase activity, enzyme binding, transferase activity, chromatin binding, epidermal growth factor-activated receptor activity, actin filament binding, protein tyrosine kinase activity, transmembrane signaling receptor activity, nucleotide binding, signal transducer activity, identical protein binding, protein heterodimerization activity, ubiquitin protein ligase binding, protein binding, signaling receptor binding, integrin binding, calmodulin binding, protein kinase binding, cadherin binding, epidermal growth factor binding, receptor tyrosine kinase, transmembrane signaling receptor activity, epidermal growth factor-activated receptor activity, epidermal growth factor binding, transmembrane receptor protein tyrosine kinase activity

External References (3)

Ensembl protein id ENSMUSP00000020329, ENSMUSP00000099948, ENSMUSP00000122632

Refseq protein id NP_031938, NP_997538, XP_036012181

Uniprot protein id Q01279

🏷️ Also known as

en avian erythroblastic leukemia viral (v-erb-b) oncogene homolog en Egfr en Epidermal growth factor receptor en waved 2

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

Class ancestry

[1] ↑ Epidermal growth factor receptor is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

Aggregate / graph-position facts

[2] ↑ Epidermal growth factor receptor is known by 4 alternative names across languages and contexts.. Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Epidermal growth factor receptor. Retrieved May 3, 2026, from https://4ort.xyz/entity/epidermal-growth-factor-receptor-q21981692

MLA

“Epidermal growth factor receptor.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/epidermal-growth-factor-receptor-q21981692.

BibTeX

@misc{4ortxyz_epidermal-growth-factor-receptor-q21981692_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Epidermal growth factor receptor}}, year = {2026}, url = {https://4ort.xyz/entity/epidermal-growth-factor-receptor-q21981692}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Epidermal growth factor receptor — https://4ort.xyz/entity/epidermal-growth-factor-receptor-q21981692 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/epidermal-growth-factor-receptor-q21981692 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

5w ago · KrBot bot · 2026-09-14 view diff on Wikidata ↗

Found in taxon → house mouse

Molecular function → kinase activity, nitric-oxide synthase regulator activity, transmembrane receptor protein tyrosine kinase activity +27

Ensembl protein id → ENSMUSP00000020329, ENSMUSP00000099948, ENSMUSP00000122632

Part of → Protein kinase-like domain superfamily, Tyrosine protein kinase, EGF/ERB/XmrK receptor, Growth factor receptor cysteine-rich domain superfamily +11

+ 9 other properties edited (see Wikidata diff for full list)

"/* wbsetclaimvalue:1| */ Biological process: ovarian cycle, разрешение перенаправления / resolving redirect ovulation cycle → ovarian cycle ([[:toollabs:editgroups/b/KrBotResolvingRedirect/Q14864005_Q"

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