epidermal growth factor
mammalian protein found in Homo sapiens
Facts
9 properties- Instance of
- protein
- Part of
- Six-bladed beta-propeller, TolB-like, Pro-epidermal growth factor, Growth factor receptor cysteine-rich domain superfamily, EGF-like calcium-binding domain, protein family, EGF-like domain, protein family, EGF-like, conserved site, protein family, LDLR class B repeat, protein family, EGF-like calcium-binding, conserved site, protein family[2][3][4][5][6][7][8][9]
- Biological process
- negative regulation of epidermal growth factor receptor signaling pathway, positive regulation of MAP kinase activity, epidermal growth factor receptor signaling pathway, regulation of protein localization to cell surface, ERK1 and ERK2 cascade, platelet degranulation, regulation of calcium ion import, mammary gland alveolus development, MAPK cascade, DNA replication, positive regulation of transcription, DNA-templated, negative regulation of secretion, positive regulation of hyaluronan biosynthetic process, positive regulation of peptidyl-threonine phosphorylation, positive regulation of ubiquitin-dependent protein catabolic process, angiogenesis, Wnt signaling pathway involved in dorsal/ventral axis specification, positive regulation of cell population proliferation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of cerebellar granule cell precursor proliferation, canonical Wnt signaling pathway, negative regulation of cholesterol efflux, peptidyl-tyrosine phosphorylation, positive regulation of DNA binding, positive regulation of phosphorylation, positive regulation of mitotic nuclear division, branching morphogenesis of an epithelial tube, signal transduction, regulation of peptidyl-tyrosine phosphorylation, ERBB2 signaling pathway, phosphatidylinositol phosphate biosynthetic process, positive regulation of protein tyrosine kinase activity, activation of transmembrane receptor protein tyrosine kinase activity, regulation of cell motility, positive regulation of receptor internalization, positive regulation of epidermal growth factor-activated receptor activity, membrane organization, negative regulation of ERBB signaling pathway, embryonic retina morphogenesis in camera-type eye, positive regulation of gene expression, positive regulation of cell migration, positive regulation of protein kinase B signaling, negative regulation of Notch signaling pathway, regulation of receptor signaling pathway via JAK-STAT, positive regulation of canonical Wnt signaling pathway, positive regulation of protein localization to early endosome[35][36][37][38][39][40][41][42][43][44]
- Cell component
- integral component of membrane, membrane, receptor complex, extracellular region, lysosomal membrane, extracellular exosome, platelet alpha granule lumen, extracellular space, clathrin-coated vesicle membrane, plasma membrane, extracellular region, extracellular space, lysosomal membrane, extracellular exosome[25][26][27][28][29][30][31][32][33][34]
- Encoded by
- EGF
- Found in taxon
- Homo sapiens
- Has part(s)
- EGF-type aspartate/asparagine hydroxylation site, EGF-like calcium-binding, conserved site, EGF-like, conserved site, EGF-like calcium-binding domain, EGF-like domain, LDLR class B repeat[10][11][12][13][14][15]
- Molecular function
- calcium ion binding, transmembrane receptor protein tyrosine kinase activator activity, epidermal growth factor receptor binding, Wnt-protein binding, protein binding, growth factor activity, Wnt-activated receptor activity, protein tyrosine kinase activity, phosphatidylinositol-4,5-bisphosphate 3-kinase activity[16][17][18][19][20][21][22][23][24]
- Physically interacts with
- epidermal growth factor receptor[1]
🏷️ Also known as
en epidermal growth factor
en beta-urogastrone
en EGF
en pro-epidermal growth factor
ar عامل نمو البشرة
cs EGF
cs epidermal growth factor
cs epidermální růstový faktor
de Epidermalwachstumsfaktor
de epidermaler Wachstumsfaktor
es EGF
es epidermal growth factor
es factor de crecimiento epidermico
es factor de crecimiento epidérmico
es factor de crecimiento transformante alfa
es TGF alfa
fa عامل رشد اپیدرمال
fi epidermikasvutekijä
fr facteur de croissance epidermique
fr epidermal growth factor
🔖 Identifiers · 12
- OpenAlex ID
- C2776362946
- Image (Wikimedia Commons)
- PDB 1ivo EBI.jpg ↗
- Ensembl protein ID
- ENSP00000265171, ENSP00000421384, ENSP00000424316, ENSP00000498337
- Exact match
- purl.uniprot.org
- Freebase ID
- /m/04k7xd
- MeSH descriptor ID
- D004815
- MeSH tree code
- D06.472.317.350, D12.644.276.382.500, D12.776.467.382.500, D23.529.382.500
- Microsoft Academic ID (discontinued)
- 2776362946
- RefSeq protein ID
- NP_001171601, NP_001171602, NP_001954, XP_005262853, XP_011530009, XP_016863334, XP_016863335, XP_016863336, XP_016863337, XP_016863338, XP_016863339, XP_016863340, XP_016863342, XP_016863343, XP_016863344, NP_001343950
- UMLS CUI
- C0242275
- UniProt protein ID
- P01133
🔗 Connections
Cell component 5
Biological process 3
Found in taxon 1
Instance of 1
Molecular function 1
Physically interacts with 1
← Different from 1
← Field of work 1
← Has effect 1
← Physically interacts with 1
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