EPH receptor B4

mammalian protein found in Homo sapiens

Protein protein Q21101191

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EPH receptor B4

Summary

EPH receptor B4 is a protein^[1].

Key Facts

EPH receptor B4's instance of is recorded as protein^[2].
EPH receptor B4's physically interacts with is recorded as tesevatinib^[3].
EPH receptor B4 is part of Immunoglobulin-like fold^[4].
EPH receptor B4 is part of Protein kinase-like domain superfamily^[5].
EPH receptor B4 is part of Fibronectin type III superfamily^[6].
EPH receptor B4 is part of ephrin receptor type-A /type-B^[7].
EPH receptor B4 is part of Galactose-binding-like domain superfamily^[8].
EPH receptor B4 is part of Growth factor receptor cysteine-rich domain superfamily^[9].
EPH receptor B4 is part of Sterile alpha motif/pointed domain superfamily^[10].
EPH receptor B4 is part of Fibronectin type III, protein family^[11].
EPH receptor B4 is part of Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[12].
EPH receptor B4 is part of EPH-B4, SAM domain, protein family^[13].
EPH receptor B4 is part of ephrin receptor^[14].
EPH receptor B4 is part of Ephrin type-B receptor 4, ligand binding domain, protein family^[15].
EPH receptor B4 is part of Sterile alpha motif domain, protein family^[16].
EPH receptor B4 is part of Tyrosine-protein kinase ephrin type A/B receptor-like, protein family^[17].
EPH receptor B4 is part of Protein kinase domain, protein family^[18].
EPH receptor B4 is part of Tyrosine-protein kinase, receptor class V, conserved site, protein family^[19].
EPH receptor B4 is part of Protein kinase, ATP binding site, protein family^[20].
EPH receptor B4 is part of Tyrosine-protein kinase, catalytic domain, protein family^[21].
EPH receptor B4 is part of Ephrin receptor ligand binding domain, protein family^[22].
EPH receptor B4 is part of Tyrosine-protein kinase, active site, protein family^[23].
EPH receptor B4 comprises ephrin receptor ligand binding domain^[24].
EPH receptor B4 comprises tyrosine-protein kinase, receptor class V, conserved site^[25].
EPH receptor B4 comprises tyrosine-protein kinase, active site^[26].

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Quick Facts

Instance of protein

Part of Immunoglobulin-like fold, Protein kinase-like domain superfamily, Fibronectin type III superfamily, ephrin receptor type-A /type-B, Galactose-binding-like domain superfamily, Growth factor receptor cysteine-rich domain superfamily, Sterile alpha motif/pointed domain superfamily, Fibronectin type III, protein family, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, EPH-B4, SAM domain, protein family, ephrin receptor, Ephrin type-B receptor 4, ligand binding domain, protein family, Sterile alpha motif domain, protein family, Tyrosine-protein kinase ephrin type A/B receptor-like, protein family, Protein kinase domain, protein family, Tyrosine-protein kinase, receptor class V, conserved site, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Ephrin receptor ligand binding domain, protein family, Tyrosine-protein kinase, active site, protein family

Properties

Biological process phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, heart morphogenesis, cell migration involved in sprouting angiogenesis, multicellular organism development, protein phosphorylation, cell adhesion, angiogenesis, protein autophosphorylation, peptidyl-tyrosine phosphorylation, ephrin receptor signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, axon guidance

Cell component integral component of membrane, cytosol, membrane, plasma membrane, integral component of plasma membrane, extracellular region, extracellular exosome, integral component of plasma membrane, neuron projection, receptor complex, extracellular exosome

Ec enzyme number 2.7.10.1

Encoded by EPHB4

Found in taxon Homo sapiens

Has part(s) ephrin receptor ligand binding domain, tyrosine-protein kinase, receptor class V, conserved site, tyrosine-protein kinase, active site, fibronectin type III, protein kinase, ATP binding site, protein kinase domain, tyrosine-protein kinase, catalytic domain, serine-threonine/tyrosine-protein kinase, catalytic domain, tyrosine-protein kinase ephrin type A/B receptor-like, sterile alpha motif domain, Ephrin receptor, transmembrane domain, Ephrin type-B receptor 4, ligand binding domain, EPH-B4, SAM domain

Molecular function transferase activity, nucleotide binding, protein kinase activity, kinase activity, protein binding, transmembrane receptor protein tyrosine kinase activity, protein tyrosine kinase activity, ATP binding, ephrin receptor activity, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity

Physically interacts with tesevatinib

External References (8)

Ensembl protein id ENSP00000350896, ENSP00000482702, ENSP00000353833

Mesh descriptor id D036224

Mesh tree code D08.811.913.696.620.682.725.400.850.750, D12.776.476.568.400.850.750, D12.776.543.750.630.500.781

Pdb structure id 2BBA, 2E7H, 2QKQ, 2VWU, 2VWV, 2VWW, 2VWX, 2VWY, 2VWZ, 2VX0, 2VX1, 2X9F, 2XVD, 2YN8, 3ZEW, 4AW5, 4BB4, 2HLE

Refseq protein id NP_004435, XP_016867305

Transporter classification database id 8.A.23.1.15

Umls cui C0907649

Uniprot protein id P54760

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ EPH receptor B4 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ EPH receptor B4 — physically interacts with (P129): tesevatinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[4] ↑ EPH receptor B4 — part of (P361): Immunoglobulin-like fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ EPH receptor B4 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ EPH receptor B4 — part of (P361): Fibronectin type III superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ EPH receptor B4 — part of (P361): ephrin receptor type-A /type-B. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ EPH receptor B4 — part of (P361): Galactose-binding-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ EPH receptor B4 — part of (P361): Growth factor receptor cysteine-rich domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ EPH receptor B4 — part of (P361): Sterile alpha motif/pointed domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ EPH receptor B4 — part of (P361): Fibronectin type III, protein family. wikidata.org.
[12] ↑ EPH receptor B4 — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[13] ↑ EPH receptor B4 — part of (P361): EPH-B4, SAM domain, protein family. wikidata.org.
[14] ↑ EPH receptor B4 — part of (P361): ephrin receptor. wikidata.org.
[15] ↑ EPH receptor B4 — part of (P361): Ephrin type-B receptor 4, ligand binding domain, protein family. wikidata.org.
[16] ↑ EPH receptor B4 — part of (P361): Sterile alpha motif domain, protein family. wikidata.org.
[17] ↑ EPH receptor B4 — part of (P361): Tyrosine-protein kinase ephrin type A/B receptor-like, protein family. wikidata.org.
[18] ↑ EPH receptor B4 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[19] ↑ EPH receptor B4 — part of (P361): Tyrosine-protein kinase, receptor class V, conserved site, protein family. wikidata.org.
[20] ↑ EPH receptor B4 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[21] ↑ EPH receptor B4 — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[22] ↑ EPH receptor B4 — part of (P361): Ephrin receptor ligand binding domain, protein family. wikidata.org.
[23] ↑ EPH receptor B4 — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[24] ↑ EPH receptor B4 — has part(s) (P527): ephrin receptor ligand binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ EPH receptor B4 — has part(s) (P527): tyrosine-protein kinase, receptor class V, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ EPH receptor B4 — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ EPH receptor B4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). EPH receptor B4. Retrieved May 3, 2026, from https://4ort.xyz/entity/eph-receptor-b4-q21101191

MLA

“EPH receptor B4.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/eph-receptor-b4-q21101191.

BibTeX

@misc{4ortxyz_eph-receptor-b4-q21101191_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{EPH receptor B4}}, year = {2026}, url = {https://4ort.xyz/entity/eph-receptor-b4-q21101191}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): EPH receptor B4 — https://4ort.xyz/entity/eph-receptor-b4-q21101191 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/eph-receptor-b4-q21101191 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

4w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Found in taxon → Homo sapiens

Physically interacts with → tesevatinib

Wikidata description → mammalian protein found in Homo sapiens

Mesh tree code → D08.811.913.696.620.682.725.400.850.750, D12.776.476.568.400.850.750, D12.776.543.750.630.500.781

+ 16 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.10.1, [[:toollabs:quickstatements/#/batch/261488|batch #261488]]"

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