EPH receptor A2
mammalian protein found in Homo sapiens
Facts
9 properties- Instance of
- protein
- Part of
- Immunoglobulin-like fold, Protein kinase-like domain superfamily, Fibronectin type III superfamily, ephrin receptor type-A /type-B, Galactose-binding-like domain superfamily, Growth factor receptor cysteine-rich domain superfamily, Sterile alpha motif/pointed domain superfamily, Fibronectin type III, protein family, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, ephrin receptor, Sterile alpha motif domain, protein family, Tyrosine-protein kinase ephrin type A/B receptor-like, protein family, Protein kinase domain, protein family, Ephrin type-A receptor 2, ligand binding domain, protein family, Tyrosine-protein kinase, receptor class V, conserved site, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Ephrin receptor ligand binding domain, protein family, Tyrosine-protein kinase, active site, protein family[1][2][3][4][5][6][7][8][9][10][11][12][13][14]
- Biological process
- regulation of lamellipodium assembly, skeletal system development, negative regulation of protein kinase B signaling, cell differentiation, regulation of cell adhesion mediated by integrin, protein kinase B signaling, activation of GTPase activity, phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, keratinocyte differentiation, vasculogenesis, multicellular organism development, protein phosphorylation, cell adhesion, blood vessel development, notochord morphogenesis, notochord cell development, angiogenesis, intrinsic apoptotic signaling pathway in response to DNA damage, neural tube development, neuron differentiation, notochord, regulation of ERK1 and ERK2 cascade, cell chemotaxis, post-anal tail morphogenesis, axial mesoderm formation, response to growth factor, viral process, cell migration, apoptotic process, peptidyl-tyrosine phosphorylation, osteoclast differentiation, osteoblast differentiation, regulation of angiogenesis, regulation of blood vessel endothelial cell migration, ephrin receptor signaling pathway, lens fiber cell morphogenesis, mammary gland epithelial cell proliferation, bone remodeling, branching involved in mammary gland duct morphogenesis, negative regulation of cytokine production, defense response to Gram-positive bacterium, negative regulation of lymphangiogenesis, blood vessel endothelial cell proliferation involved in sprouting angiogenesis, pericyte cell differentiation, negative regulation of angiogenesis, inflammatory response, negative regulation of chemokine production, blood vessel morphogenesis, cAMP metabolic process, cell motility, viral entry into host cell, positive regulation of protein localization to plasma membrane, transmembrane receptor protein tyrosine kinase signaling pathway, axon guidance, protein localization to plasma membrane, positive regulation of bicellular tight junction assembly
- Cell component
- integral component of membrane, cell projection, membrane, ruffle membrane, cell junction, lamellipodium membrane, leading edge membrane, focal adhesion, integral component of plasma membrane, intracellular anatomical structure, plasma membrane, lamellipodium, cell surface, integral component of plasma membrane, focal adhesion, cell surface, neuron projection, receptor complex, tight junctions[40][41][42][43][44][45]
- EC enzyme number
- 2.7.10.1[27]
- Encoded by
- EPHA2
- Found in taxon
- Homo sapiens
- Has part(s)
- tyrosine-protein kinase, active site, protein kinase domain, serine-threonine/tyrosine-protein kinase, catalytic domain, protein kinase, ATP binding site, ephrin receptor ligand binding domain, tyrosine-protein kinase, receptor class V, conserved site, sterile alpha motif domain, tyrosine-protein kinase ephrin type A/B receptor-like, tyrosine-protein kinase, catalytic domain, Ephrin receptor, transmembrane domain, fibronectin type III, Ephrin type-A receptor 2, ligand binding domain[15][16][17][18][19][20][21][22][23][24][25][26]
- Molecular function
- nucleotide binding, protein kinase activity, transferase activity, kinase activity, protein binding, protein tyrosine kinase activity, ATP binding, ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity, cadherin binding, virus receptor activity, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity, cadherin binding[28][29][30][31][32][33][34][35][36][37][38][39]
🏷️ Also known as
en EPHA2
en EPH receptor A2
en ephrin type-A receptor 2
en Epithelial cell kinase
en epithelial cell receptor protein tyrosine kinase
en soluble EPHA2 variant 1
en tyrosine-protein kinase receptor ECK
🔖 Identifiers · 8
- Ensembl protein ID
- ENSP00000351209
- Exact match
- identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov
- MeSH descriptor ID
- D036104
- MeSH tree code
- D08.811.913.696.620.682.725.400.850.100, D12.776.543.750.630.500.100, D12.776.476.568.400.850.100
- PDB structure ID
- 1MQB, 2E8N, 2K9Y, 2KSO, 2X10, 2X11, 3C8X, 3CZU, 3FL7, 3HEI, 3HPN, 3KKA, 3MBW, 3MX0, 3SKJ, 4P2K, 4PDO, 4TRL, 5EK7
- RefSeq protein ID
- NP_001316019, NP_004422, XP_016856026
- UMLS CUI
- C0763620
- UniProt protein ID
- P29317
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